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8 results on '"Sokolovski S"'

1. Wearable laser Doppler sensors for evaluating the nutritive and shunt blood flow

Author

Loktionova, Y. I. (Yulia I.), Zharkikh, E. V. (Elena V.), Zherebtsov, E. A. (Evgeny A.), Kozlov, I. O. (Igor O.), Sidorov, V. V. (Viktor V.), Zherebtsova, A. I. (Angelina I.), Sokolovski, S. G. (Sergei G.), Dunaev, A. V. (Andrey V.), and Rafailov, E. U. (Edik U.)

Subjects
ageing, laser Doppler owmetry, bypass index, diabetes mellitus, microcirculation, nutritive and shunt blood flow
Abstract

This study is devoted to the trials of wearable diagnostic system that implements the laser Doppler flowmetry technique to analyse the blood microcirculation. We do preliminary test with involvement of limited group of healthy volunteers of different age and in patients with type 2 diabetes. During the series of measurements, the microcirculation parameters was measured for 10 minutes in the palmar surfaces of the big toes and in the inner sides of the upper thirds of the shins. A statistically significant differences was found in bypass index, nutritive and shunt blood ow in shins between older group of volunteers and patients’ group as well as in shunt blood flow in fingers between younger and older groups of volunteers.

Published
2020

2. Wearable sensor system for multipoint measurements of blood perfusion:pilot studies in patients with diabetes mellitus

Author

Zherebtsov, E. A. (Evgeny A.), Zharkikh, E. V. (Elena V.), Kozlov, I. O. (Igor O.), Loktionova, Y. I. (Yulia I.), Zherebtsova, A. I. (Angelina I.), Rafailov, I. E. (Ilya E.), Sokolovski, S. G. (Sergei G.), Sidorov, V. V. (Victor V.), Dunaev, A. V. (Andrey V.), and Rafailov, E. U. (Edik U.)

Subjects
Ageing, Diabetes mellitus, Laser Doppler owmetry, Wearable blood perfusion sensor, Blood flow
Abstract

The growing interest in the development of new wearable electronic devices for mobile healthcare provides great opportunities for the development of methods for assessing blood perfusion in this direction. Laser Doppler flowmetry (LDF) is one of the promising methods. A fine analysis of capillary blood ow structure and rhythm in the time and frequency domains, coupled with a new possibility of round-the-clock monitoring can provide valuable diagnostic information about the state of microvascular blood ow. In this study, wearable implementation of laser Doppler flowmetry was utilised for microcirculatory function assessment in patients with diabetes and healthy controls of two distinct age groups. Four wearable laser Doppler flowmetry monitors were used for the analysis of blood microcirculation. Thirty-seven healthy volunteers and 18 patients with type 2 diabetes mellitus participated in the study. The results of the studies have shown that the average perfusion differs between healthy volunteers of distinct age groups and between healthy volunteers of the younger age group and patients with diabetes mellitus. It was noted that the average level of perfusion measured on the wrist in the two groups of healthy volunteers has no statistically significant differences found in similar measurements on the fingertips. The wearable implementation of LDF can become a truly new diagnostic interface to monitor cardiovascular parameters, which could be of interest for diagnostics of conditions associated with microvascular disorders.

Published
2019

3. Novel wearable VCSEL-based sensors for multipoint measurements of blood perfusion

Author

Zherebtsov, E. A. (Evgeny A.), Zharkikh, E. V. (Elena V.), Kozlov, I. O. (Igor O.), Zherebtsova, A. I. (Angelina I.), Loktionova, Y. I. (Yulia I.), Chichkov, N. B. (Nikolai B.), Rafailov, I. E. (Ilya E.), Sidorov, V. V. (Victor V.), Sokolovski, S. G. (Sergei G.), Dunaev, A. V. (Andrey V.), and Rafailov, E. U. (Edik U.)

Subjects
VCSEL lasers, Laser Doppler owmetry, wearable sensors, blood perfusion
Abstract

A novel non-invasive, wearable VCSEL-based system for multipoint in − vivo measurements of blood perfusion was introduced. The system operates on the basis of the laser Doppler flowmetry (LDF) method and allows for microcirculation studies. The sensors developed were used to analyse the skin blood flow synchronization in homologous regions of the contralateral limbs, both in the basal state and during various functional tests. A high synchronisation of blood flow rhythms in the contralateral limbs of healthy volunteers was shown in the studies presented.

Published
2019

4. Pilot studies of age-related changes in blood perfusion in two different types of skin

Author

Loktionova, Y. I. (Yulia I.), Zharkikh, E. V. (Elena V.), Kozlov, I. O. (Igor O.), Zherebtsov, E. A. (Evgeny A.), Bryanskaya, S. A. (Svetlana A.), Zherebtsova, A. I. (Angelina I.), Sidorov, V. V. (Victor V.), Sokolovski, S. G. (Sergei G.), Dunaev, A. V. (Andrey V.), Rafailov, E. U. (Edik U.), Loktionova, Y. I. (Yulia I.), Zharkikh, E. V. (Elena V.), Kozlov, I. O. (Igor O.), Zherebtsov, E. A. (Evgeny A.), Bryanskaya, S. A. (Svetlana A.), Zherebtsova, A. I. (Angelina I.), Sidorov, V. V. (Victor V.), Sokolovski, S. G. (Sergei G.), Dunaev, A. V. (Andrey V.), and Rafailov, E. U. (Edik U.)

Abstract

Laser Doppler flowmetry (LDF) was utilized to assess age-related changes in the blood microcirculation at the skin sites with different morphology and regulation. The LDF signals obtained from the glabrous skin of the middle finger pad and nonglabrous skin on the dorsal wrist surface were analyzed. Statistically higher baseline perfusion was observed in the zone with glabrous skin in the older group of volunteers compared to younger participants. Observed site-specific and age-related differences in perfusion can be used in the future experimental design for the studies of the blood microcirculation system in patients with different pathologies.

Published
2019

5. Studies of age-related changes in blood perfusion coherence using wearable blood perfusion sensor system

Author

Loktionova, Y. I. (Yulia I.), Zherebtsov, E. A. (Evgeny A.), Zharkikh, E. V. (Elena V.), Kozlov, I. O. (Igor O.), Zherebtsova, A. I. (Angelina I.), Sidorov, V. V. (Victor V.), Sokolovski, S. G. (Sergei G.), Rafailov, I. E. (Ilya E.), Dunaev, A. V. (Andrey V.), Rafailov, E. U. (Edik U.), Loktionova, Y. I. (Yulia I.), Zherebtsov, E. A. (Evgeny A.), Zharkikh, E. V. (Elena V.), Kozlov, I. O. (Igor O.), Zherebtsova, A. I. (Angelina I.), Sidorov, V. V. (Victor V.), Sokolovski, S. G. (Sergei G.), Rafailov, I. E. (Ilya E.), Dunaev, A. V. (Andrey V.), and Rafailov, E. U. (Edik U.)

Abstract

Laser Doppler flowmetry (LDF) was used for detection of age-related changes in the blood microcirculation. The LDF signal was simultaneously recorded from the 3rd fingers’ pads of both hands. Amplitudes of the blood flow oscillations and wavelet coherence of the signals were used for the data analysis. A statistical difference in the synchronisation of myogenic oscillations was found between the two studied age groups. Myogenic oscillations of blood perfusion in the younger group had a higher wavelet coherence parameter than in the older group. Observed site-specific and age-related differences in blood perfusion can be used in the future in the design of experimental studies of the blood microcirculation system in patients with different pathologies.

Published
2019

6. Multimodal optical measurement for study of lower limb tissue viability in patients with diabetes mellitus

Author

Dremin, V. V. (Viktor V.), Zherebtsov, E. A. (Evgeny A.), Sidorov, V. V. (Victor V.), Krupatkin, A. I. (Alexander I.), Makovik, I. N. (Irina N.), Zherebtsova, A. I. (Angelina I.), Zharkikh, E. V. (Elena V.), Potapova, E. V. (Elena V.), Dunaev, A. V. (Andrey V.), Doronin, A. A. (Alexander A.), Bykov, A. V. (Alexander V.), Rafailov, I. E. (Ilya E.), Litvinova, K. S. (Karina S.), Sokolovski, S. G. (Sergei G.), and Rafailov, E. U. (Edik U.)

Subjects
mitochondrial function, advanced glycation end products, diabetes mellitus, diagnostic volume, fluorescence spectroscopy, laser Doppler flowmetry, metabolism
Abstract

According to the International Diabetes Federation, the challenge of early stage diagnosis and treatment effectiveness monitoring in diabetes is currently one of the highest priorities in modern healthcare. The potential of combined measurements of skin fluorescence and blood perfusion by the laser Doppler flowmetry method in diagnostics of low limb diabetes complications was evaluated. Using Monte Carlo probabilistic modeling, the diagnostic volume and depth of the diagnosis were evaluated. The experimental study involved 76 patients with type 2 diabetes mellitus. These patients were divided into two groups depending on the degree of complications. The control group consisted of 48 healthy volunteers. The local thermal stimulation was selected as a stimulus on the blood microcirculation system. The experimental studies have shown that diabetic patients have elevated values of normalized fluorescence amplitudes, as well as a lower perfusion response to local heating. In the group of people with diabetes with trophic ulcers, these parameters also significantly differ from the control and diabetes only groups. Thus, the intensity of skin fluorescence and level of tissue blood perfusion can act as markers for various degrees of complications from the beginning of diabetes to the formation of trophic ulcers.

Published
2017

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