1. In vivo microscopic imaging for diagnosis of fibrotic interstitial lung disease using endobronchial optical coherence tomography
- Author
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Christopher R. Morse, Colleen Keyes, John C. Wain, Rebecca A. Israel, Lida P. Hariri, Benjamin D. Medoff, Harald C. Ott, Cameron D. Wright, Peter Caravan, Melissa J. Suter, David C. Adams, Nora Horick, Hugh Auchincloss, Mari Mino-Kenudson, Thomas V. Colby, Benjamin W. Roop, Amita Sharma, Angela R. Shih, Margit V. Szabari, Lloyd L. Liang, Henning A. Gaissert, Michael Lanuti, Diane L. Davies, Sreyankar Nandy, and Ashok Muniappan
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Interstitial lung disease ,respiratory system ,medicine.disease ,respiratory tract diseases ,Idiopathic pulmonary fibrosis ,Optical coherence tomography ,In vivo ,Pulmonary fibrosis ,medicine ,Microscopic imaging ,Medical imaging ,In patient ,Radiology ,business - Abstract
Early, accurate diagnosis of interstitial lung disease (ILD) is critical for clinical management and therapeutic decision-making, especially distinguishing idiopathic pulmonary fibrosis (IPF) from non-IPF ILD. Unfortunately, current diagnostic imaging methods are limited in resolution and surgical biopsy methods are invasive. In this study, we evaluate the accuracy of endobronchial optical coherence tomography (EB-OCT) as a low-risk method for in vivo ILD diagnosis in patients undergoing surgical biopsy. EB-OCT was able to distinguish diagnostic microanatomical features of IPF from non-IPF ILDs, independently compared against surgical biopsy. These findings support the potential of OCT as a minimally-invasive method for IPF diagnosis.
- Published
- 2021