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153,194 results

29. Towards point-of-care detection of microRNAs using paper-based microfluidics

Author

Siddhant Jaitpal, Samuel Mabbott, and Suhash Reddy Chavva

Subjects
Limited access, medicine.medical_specialty, Biomarker, business.industry, Transmission (medicine), Public health, medicine, Disease, Hiv status, Paper based, Intensive care medicine, business, Point of care
Abstract

Human immunodeficiency virus (HIV) weakens a person’s immune system by destroying cells which are important to fighting the disease and infection. HIV is a major global public health issue with an estimated 38 million people living with HIV at the end of 2019. There is no cure for HIV. However, increased access to effective prevention, diagnosis and treatment has enabled people living with HIV to lead healthy lives. Rapid diagnosis forms an important part of the WHO’s strategy for ensuring those who are HIV positive have immediate access to care. Perhaps more critical however is that effective diagnostic testing informs individuals of their HIV status, reducing the risk of transmission. HIV prevalence within the US is disproportionately high amongst Black/African American and Hispanic/Latino American populations who often have limited access to advanced medical clinics. In this paper, we present a lateral flow device designed to detect miR-150-5p; an emerging biomarker of HIV. Based on our preliminary results shown here, we are capable of detecting the miRNA sequence at sub-ng uL-1 using colorimetric analysis, without prior amplification of the target material. We have also detailed our initial results obtained from surface-enhanced Raman scattering measurements made at the device capture line, whilst the standard deviations are large, the technique shows lots of promise for lowering the detection limit in the future.

Published
2021

44. Paper-based platforms for the detection of DNA with plasmonic particles (Conference Presentation)

Author

Maria Minunni, Sofia Chioccioli, Fulvio Ratto, Simona Scarano, Sonia Centi, Roberto Pini, Claudia Borri, and Patrizia Bogani

Subjects
Presentation, Biological target, Computer science, media_common.quotation_subject, Identification (biology), Paper based, Data science, media_common
Abstract

The detection of DNA from a biological target is becoming a powerful tool for several applications. In particular, the development of approaches for fast and sensitive identification of genomic footprints in open-field or POCT contexts would have a tremendous impact on the identification of fraudulent or pathogenic contaminations.

Published
2020

45. A computational paper-based point-of-care assay for high-sensitivity c-reactive protein quantification (Conference Presentation)

Author

Zachary S. Ballard, Hyou-Arm Joung, Aydogan Ozcan, Dino Di Carlo, Jesse Liang, Omai B. Garner, Artem Goncharov, and Karina Nugroho

Subjects
Presentation, biology, Computer science, media_common.quotation_subject, C-reactive protein, biology.protein, Sensitivity (control systems), Computational biology, Paper based, media_common, Point of care
Published
2020