Search

Your search keyword '"Božović, N."' showing total 2 results
Start Over Author "Božović, N." Publisher society of physical chemists of serbia
2 results on '"Božović, N."'

1. Fluoxetine normalized nuclear phospho erk1/2 signaling in stressed females

Author

Mitić, Miloš, Lukić, Iva, Božović, N., Đorđević, Jelena D., and Adžić, Miroslav

Abstract

A growing body of evidence indicates extracellular signal-regulated kinase (ERK1/2) participates in various stress-induced responses which isconsider to beinvolved in pathophysiology of depression. Surprisingly, the effect of antidepressants on ERKs is almost unexplored, particularly from the perspective of sexes.In the present study, we investigated the potential role of cytoplasm-nuclear distribution of phospho-ERK1/2 in the hippocampus of chronically stressed female and male Wistar rats and if those potential changes could be attenuated with chronic fluoxetine treatment. In females, stress induced cytosolic retention of phospho-ERKs, while in malesitpromoted the nuclear translocation of phospho-ERK 1/2. The effect of concomitant fluoxetine treatment was more pronounced in stressed females, with main focus on normalization of its nuclear phospho-ERK 1/2 levels.

Published
2014

2. Involvement of prefrontal cortex cdk5 pathway in lps-induced depressive-like behavior in male and female wistar rats

Author

Brkić, Željka, Lukić, Iva, Mitić, Miloš, Božović, N., Brašanac, Jelena, Đorđević, Jelena, Adžić, Miroslav, Brkić, Željka, Lukić, Iva, Mitić, Miloš, Božović, N., Brašanac, Jelena, Đorđević, Jelena, and Adžić, Miroslav

Abstract

Systemic exposure to inflammatory challenges, such as lipopolysaccharide (LPS), can induce a central neuroinflammation, which has been associated with the development of major depressive disorder (MDD). Research data emphasize not only sex as an important factor in the pathogenesis of MDD but also point out a disturbance in cyclin-dependent kinase 5 (CDK5) pathway. Therefore, in this study, we investigated the effects of LPS treatment on depressive-like behavior as well as on the CDK5 and p35 levels in the cytosol and the nucleus of the prefrontal cortex of Wistar rats. Our results showed that LPS causes a depressive-like behavior in both sexes, as well as significant changes in the levels of CDK5 and p35, but only in the males. Such differences of CDK5 activity could contribute to the development of depressive-like behavior in males, while in females it seems that some other mechanisms could be involved in the induction of this behavior.

Published
2014

Catalog

Books, media, physical & digital resources
See catalog results