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Your search keyword '"Borowsky, Jennifer"' showing total 3 results
Start Over Author "Borowsky, Jennifer" Publisher society of nuclear medicine
3 results on '"Borowsky, Jennifer"'

1. PET Imaging Quantifying 68Ga-PSMA-11 Uptake in Metastatic Colorectal Cancer

Author

Cuda, Tahleesa J., primary, Riddell, Andrew D., additional, Liu, Cheng, additional, Whitehall, Vicki L., additional, Borowsky, Jennifer, additional, Wyld, David K., additional, Burge, Matthew E., additional, Ahern, Elizabeth, additional, Griffin, Alison, additional, Lyons, Nicholas J.R., additional, Rose, Stephen E., additional, Clark, David A., additional, Stevenson, Andrew R.L., additional, Hooper, John D., additional, Puttick, Simon, additional, and Thomas, Paul A., additional

Published
2020
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3. PET Imaging Quantifying 68 Ga-PSMA-11 Uptake in Metastatic Colorectal Cancer.

Author

Cuda TJ, Riddell AD, Liu C, Whitehall VL, Borowsky J, Wyld DK, Burge ME, Ahern E, Griffin A, Lyons NJR, Rose SE, Clark DA, Stevenson ARL, Hooper JD, Puttick S, and Thomas PA

Subjects
Colorectal Neoplasms pathology, Colorectal Neoplasms radiotherapy, Dipeptides therapeutic use, Edetic Acid pharmacokinetics, Gallium Isotopes, Gallium Radioisotopes, Heterocyclic Compounds, 1-Ring therapeutic use, Humans, Lutetium, Neoplasm Metastasis, Prostate-Specific Antigen, Radioisotopes, Colorectal Neoplasms diagnostic imaging, Edetic Acid analogs & derivatives, Oligopeptides pharmacokinetics, Positron-Emission Tomography methods, Radiopharmaceuticals pharmacokinetics
Abstract

At diagnosis, 22% of colorectal cancer (CRC) patients have metastases, and 50% later develop metastasis. Peptide receptor radionuclide therapy (PRRT), such as 177 Lu-PSMA-617, is used to treat metastatic prostate cancer. 177 Lu-PSMA-617 targets prostate-specific membrane antigen (PSMA), a cell-surface protein enriched in prostate cancer and the neovasculature of other solid tumors, including CRC. We performed 68 Ga-PSMA-11 PET/CT imaging of 10 patients with metastatic CRC to assess metastasis avidity. Eight patients had lesions lacking avidity, and 2 had solitary metastases exhibiting very low avidity. Despite expression of PSMA in CRC neovasculature, none of the patients exhibited tumor avidity sufficient to be considered for 177 Lu-PSMA-617 PRRT., (© 2020 by the Society of Nuclear Medicine and Molecular Imaging.)

Published
2020
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