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In our work, we focused on monitoring the enzymatic activities of LDH, AST, ALT and GLU in the blood serum of pigs (piglets) from the age of 21 days old to 42 days old. Subscriptions were made once each week in the morning on an empty stomach, from the eye veny (vena ophtalmica). All experimental animals were fed with compound feed COS1, COS2, without any feed additives. Piglets were divided into two groups. The first group was the control group (n = 7 piglets ) and the second was the experimental group (n = 7 piglets), which was given sage (Salvia officinalis L.) and oregano (Origanum vulgare L.) in the form of essential oils in concentrations of 0.05%. The average results of observed enzymatic activities of the 21 day old piglets were as follows: control group of piglets: LDH – 10,3 µkat/l, AST – 0,84 µkat/l a ALT – 1,75 µkat/l a GLU -5,33mmol/l and in the experimental group the results of observed enzymatic activities were : LDH – 9,09 µkat/l, AST – 0,71 µkat/l , ALT – 0,96 µkat/l a GLU – 5,97mmol/l. The sampling was repeated when the piglets reached 42 days old and in both groups we found out that the results of enzymatic activities in LDH and AST were higher and in ALT and GLU they were lower.