1. Eyes With Acute, Treatment-Naïve CRVO and Foveal Intraretinal Hemorrhage: Characteristics and Outcomes
- Author
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Stephen P. Yoon, Sharon Fekrat, Faith A. Birnbaum, Mark Goerlitz-Jessen, Tahreem A. Mir, and Akshay S. Thomas
- Subjects
Male ,Vascular Endothelial Growth Factor A ,Intraretinal hemorrhage ,Fovea Centralis ,medicine.medical_specialty ,Visual acuity ,genetic structures ,Visual Acuity ,Angiogenesis Inhibitors ,Multimodal Imaging ,Therapy naive ,03 medical and health sciences ,0302 clinical medicine ,Central retinal vein occlusion ,Foveal ,Ophthalmology ,Retinal Vein Occlusion ,medicine ,Humans ,Fluorescein Angiography ,Aged ,Retrospective Studies ,Retrospective review ,Laser Coagulation ,business.industry ,Treatment burden ,Retinal Hemorrhage ,Middle Aged ,medicine.disease ,eye diseases ,Bevacizumab ,Treatment Outcome ,Acute Disease ,Intravitreal Injections ,030221 ophthalmology & optometry ,Female ,sense organs ,medicine.symptom ,business ,Tomography, Optical Coherence - Abstract
BACKGROUND AND OBJECTIVE: To compare outcomes in eyes with central retinal vein occlusion (CRVO) presenting with (group 1) or without (group 2) fovea-involving intraretinal hemorrhage (IRH). PATIENTS AND METHODS: Retrospective review of patients diagnosed with acute, treatment-naïve CRVO between January 2009 and July 2016. RESULTS: One hundred fifteen (39.8%) of 289 CRVO eyes had fovea-involving IRH. At baseline, eyes in group 1 had significantly worse visual acuity (VA) (1.2 ± 0.10 logMAR vs. 0.9 ± 0.06 logMAR; P = .001) and greater central subfield thickness (CST) (610.4 μm ± 35.9 μm vs. 435.0 μm + 21.6 μm; P < .001) than eyes in group 2. Final visual outcomes were comparable between groups (1.24 ± 0.09 logMAR vs. 1.02 ± 0.08 logMAR; P = .08). Group 1 received a significantly greater number of intravitreal anti-vascular endothelial growth factor injections during the first year (7.80 ± 0.40 vs. 5.20 ± 0.40; P = .001). CONCLUSIONS: Although treatment-naïve eyes with acute CRVO and fovea-involving IRH had worse VA and greater CST at presentation, the final VA was comparable to eyes without such a hemorrhage. Eyes with foveal IRH had a greater treatment burden in the first 12 months. [ Ophthalmic Surg Lasers Imaging Retina . 2019;50:752–759.]
- Published
- 2019
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