1. New Developments in Neonatology: Less Severe Retinopathy of Prematurity?
- Author
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J. U. M. Termote, A.R.T. Donders, Bernard P. Cats, Hens A. A. Brouwers, and Nicoline E. Schalij-Delfos
- Subjects
congenital, hereditary, and neonatal diseases and abnormalities ,Pediatrics ,medicine.medical_specialty ,Neonatal intensive care unit ,genetic structures ,medicine.medical_treatment ,High-Frequency Ventilation ,macromolecular substances ,Severity of Illness Index ,Risk Factors ,Intensive Care Units, Neonatal ,Severity of illness ,medicine ,Humans ,Retinopathy of Prematurity ,Neonatology ,Netherlands ,Quality of Health Care ,Retrospective Studies ,Respiratory distress ,business.industry ,Incidence ,Incidence (epidemiology) ,High-frequency ventilation ,Infant, Newborn ,Infant ,Pulmonary Surfactants ,Retinopathy of prematurity ,Retrospective cohort study ,General Medicine ,medicine.disease ,eye diseases ,Ophthalmology ,Logistic Models ,Pediatrics, Perinatology and Child Health ,sense organs ,business ,Infant, Premature - Abstract
Purpose: To determine the effects of surfactant replacement therapy (SRT), high-frequency oscillatory ventilation (HFOV), and general improvements in quality of care on the incidence of severe retinopathy of prematurity (ROP). Methods: Retrospective comparison of the incidence and severity of ROP in two groups of preterm infants admitted to our neonatal intensive care unit (NICU) in two consecutive 5-year periods (1986-1995) and screened for ROP. During the second study period, natural surfactant was introduced in the treatment of respiratory distress syndrome (RDS) and HFOV was used for treatment of respiratory insufficiency of any origin. The effects of these developments and general improvements on the incidence of severe ROP were analyzed with stepwise logistic regression. Results: The overall incidence of ROP from 19861990 was not significantly different from the incidence of ROP from 1 991 -1 995. The incidence of severe ROP (ROP stage 3 or greater) was significantly lower in the second period (15.7% versus 6.4%, P=.015). For infants Conclusion: Of the recent new developments in neonatology, only SRT was associated with a decreased risk for severe ROP. Journal of Pediatric Ophthalmology and Strabismus 2000;37:142-148.
- Published
- 2000