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The elastic sliding isolation bearings were fixed at the top of the middle columns, a two-dimensional finite element model for the static-dynamic coupling interaction of soil-underground structure was established, and the seismic response of underground subway station, such as the lateral deformation, stress responses and the seismic damage were analyzed. It showed that the elastic sliding bearings fixed on the top of columns could effectively mitigate the seismic damage of the middle columns and the middle plate and keep middle columns completely under compress condition during the earthquake. As a result, it could improve the overall seismic performance of the underground station structure due to the important role of middle columns in the seismic resistance of underground subway station. However, the elastic sliding bearings fixed on the top of columns could also weaken the anti-lateral rigidity of the underground station structure and the plane buckling rigidity of the plates, which significantly amplified the lateral deformation response of the underground station structure. Meanwhile, middle columns changed the dynamic deformation mode of the underground station structure, which obviously aggravated the seismic damages of the top and bottom plates close to the side wall of the underground station structure. [ABSTRACT FROM AUTHOR]