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行心脏手术治疗的患者大多心功能较差, 对麻醉的耐受性低, 因此在手术过程中合理选择麻醉药物对心 脏疾病患者术中维持血流动力学稳定、减少应激至关重要. 瑞马唑仑是-种新型镇静药物, 麻醉诱导具有起效迅 速、恢复快、血流动力学稳定及呼吸抑制轻微等优点, 已先后批准用于程序性镇静及全身麻醉. 目前, 瑞马唑仑在心 脏手术患者全身麻醉中应用的相关研究较少且样本量较小, 但其在心脏瓣膜置换术、冠状动脉旁路移植术、经皮二 尖瓣钳夹术等心脏手术中被发现可维持患者术中循环稳定性且不良反应较少. 瑞马唑仑具有较高有效性及较好安 全性, 有望成为行心脏手术治疗患者全身麻醉的候选镇静新药. [ABSTRACT FROM AUTHOR]

选择性腰神经根阻滞（SNRB）是指在各种影像学设备定位引导下，根据需要选择性地对腰段神经根进行穿 刺阻滞的微创技术。传统C臂X线和CT引导下SNRB对于腰神经参与支配区域的神经病理性疼痛具有很高的诊断价 值。近年来，随着超声技术不断发展，超声引导下SNRB因其具有准确、安全、有效、实时等优势，逐渐用于下肢手术围 术期的麻醉与镇痛，尤其适用于老年患者。总之，SNRB为临床麻醉与镇痛提供了一种新的选择。 [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

新生儿脑白质损伤(WMI)是一种复杂和多因素的脑损伤,以少突胶质细胞发育过程中断和(或)死亡致髓鞘减少或髓鞘形成障碍为主要发病机制,涉及多种信号通路和表观遗传因子.目前研究较多的信号通路包括丝裂原活化蛋白激酶(MAPK)通路、血小板生长因子(PDGF)通路、Notch通路、Wnt/β-catenin通路、BMP4通路、雷帕霉素靶蛋白(mTOR)通路、甲状腺激素通路.了解WMI相关信号通路是揭示髓鞘形成和WMI机制的重要前提,有助于为开发新的临床治疗方案提供帮助. [ABSTRACT FROM AUTHOR]

Objective To constructthe oligodendrocytes model with high expression of neurofascin 155( NF155).Methods NF155 c DNA was cloned by RT-PCR and inserted into p UM-T simple vector by T-A clone methodand double digestion to construct a lentivirus vector plasmid. Nhe I and Age I were used to cut off the target gene,the size of the fragment and gene sequencing showed that the lentivirus vector plasmid was successfully constructed. Oligodendrocytes in logarithmic growth phase were divided into the blank control group,negative lentivirus infection group,and NF155 lentivirus infection group. The blank control group was not treated,the negative lentivirus infection group was treated with 10 μL empty vector lentivirus + 100 μL medium,and the NF155 lentivirus infection group with 10 μL lentivirus vector plasmid +100 μL medium. The mRNA and protein expression levels of NF155 were detected by real-time PCRand Western blotting.Results The relative expression levels of NF155 mRNA in the NF155 lentivirus infection group,blank control group and negative lentivirus infection group were 3. 25 ± 0. 11,1. 00 ± 0. 06,and 1. 08 ± 0. 01,respectively. The relative expression of NF155 mRNA in the NF155 lentivirus infection group was higher than that in the blank control group and negative lentivirus infection group( P < 0. 05). The relative expression levelsof NF155 protein in the lentivirus infection group,blank control group,and negative lentivirus infection group were 1. 57 ± 0. 08,0. 51 ± 0. 12,and 0. 50 ± 0. 06,respectively. The lentivirus infection group had higher relative expression of NF155 proteinthan the blank control group and negative lentivirus infection group( P < 0. 05). Conclusion The oligodendrocytes transient cell model with high expression of NF155 is successfully constructed. [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

关节假体周围感染是人工关节置换术后最严重的并发症之一,常导致患者关节剧烈疼痛,人工关节失效,最终不得不进行翻修手术。糖尿病、营养状态差、病态肥胖、贫血、吸烟史、类风湿性关节炎、肝肾相关疾病等为人工关节置换术后关节假体周围感染的危险因素,称为机体不可改变因素。术前关节腔穿刺、无症状性菌尿、鼻腔定植菌等三个潜在危险因素可在术前进行处理,故称为机体可改变因素;上述三个潜在危险因素可能与关节假体周围感染有关,需纳入术前考虑范畴。 [ABSTRACT FROM AUTHOR]

目的 观察神经内镜辅助微血管减压术(MVD)治疗面肌痉挛的临床效果.方法 拟行手术治疗的面肌痉挛患者127例,根据手术方式不同分为观察组57例和对照组70例.观察组采用神经内镜辅助MVD治疗,对照组采用单纯MVD治疗.术后观察患者恢复情况,至少随访6个月并评估疗效,计算总有效率.观察患者术后头痛、头晕、耳鸣或听力下降等并发症发生情况,计算并发症发生率.结果 MVD术中,观察组1例未明确责任血管,对照组5例未发现明显责任血管.观察组治愈48例、缓解8例、无效1例、总有效率为98.25%,对照组分别为55例、7例、8例和88.57%,观察组总有效率高于对照组(P<0.05).所有患者术后至少随访6个月,共15例延迟治愈,无复发患者.观察组术后发生头痛、头晕1例,耳鸣、听力下降1例,并发症发生率为3.51%;对照组术后发生头痛、头晕2例,耳鸣5例,听力下降3例,并发症发生率为14.29%;观察组术后并发症发生率低于对照组(P<0.05).结论 神经内镜辅助MVD治疗面肌痉挛可提高手术有效率,降低并发症发生率,效果较好. [ABSTRACT FROM AUTHOR]

目的探讨新辅助介入动脉化疗对宫颈癌组织基质细胞衍生因子1(SDF-1)及其受体基质细胞衍生因子受体4(CXCR4)表达的影响。方法选择72例Ⅰb~Ⅱb期宫颈癌患者,随机分为新辅助介入动脉化疗组(治疗组)36例和新辅助静脉化疗组(对照组)36例。化疗结束2周后,综合评定化疗的近期疗效;收集两组术前及术后肿瘤组织,采用免疫组织化学SP法检测宫颈癌组织SDF-1、CXCR4蛋白表达。结果对照组CR 2例、PR 29例、SD 5例、PD 0例、总有效率为86.11%,治疗组分别为5、28、3、0例及91.67%,两组近期疗效差异无统计学意义(P>0.05)。对照组、治疗组发生2度及以上不良反应发生率分别为94.4%、69.4%,治疗组2度及以上不良反应的发生率低于对照组(P<0.05)。两组化疗后SDF-1、CXCR4蛋白阳性表达率均低于化疗前(P均<0.05)。两组化疗后SDF-1、CXCR4表达差异均无统计学意义(P均>0.05)。结论新辅助介入动脉化疗可明显降低宫颈癌组织SDF-1、CXCR4蛋白表达,且能够明显降低不良反应发生率。 [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的：探讨烧伤患者术后谵妄的发生情况及其相关影响因素。方法对237例烧伤患者术后谵妄情况进行回顾性分析。依据患者的年龄、性别、文化程度、手术时间、术中低血压、术中低氧血症、术后入住ICU、术后感染、烧伤面积情况，分析烧伤患者术后谵妄的影响因素。结果本组烧伤患者术后谵妄发生率为13．1％（31／237）；单因素分析结果显示，年龄、文化程度、手术时间、术中低血压、术中低氧血症、术后入住ICU、术后感染、烧伤面积与烧伤患者术后谵妄的发生相关（P均＜0．05）；多因素Logistic回归分析显示，年龄、文化程度、手术时间、术中低血压、术中低氧血症、术后入住ICU、术后感染是烧伤患者发生术后谵妄的主要影响因素（P均＜0．05）。结论烧伤患者术后容易发生谵妄，年龄、文化程度、手术时间、术中低血压、术中低氧血症、术后回ICU、术后感染是其主要影响因素。 [ABSTRACT FROM AUTHOR]

目的：探讨后腹腔镜保留肾单位手术治疗肾肿瘤的临床疗效。方法选择16例肾肿瘤患者，肿瘤直径平均2．4 cm。均采用后腹腔镜行保留肾单位手术，术中采用冰屑水肾蒂周围降温，三明治法缝合肾脏创面。观察手术时间、术中出血量、肾脏缺血时间、术后并发症等。结果16例手术顺利完成，无中转行开放手术者。肾动脉阻断时间18～22 min、平均20 min，手术时间96～168 min、平均118 min，术中出血量40～400 mL、平均120 mL。术后无出血、漏尿等并发症。术后随访6～30个月，患者肾功能及GFR均正常，肿瘤无局部复发。结论后腹腔镜保留肾单位术切除肾肿瘤疗效满意，可缩短手术时间，减少肾热缺血时间，并可有效保护肾功能。 [ABSTRACT FROM AUTHOR]