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Objective To investigate the predictive value of heart rate-corrected QT (QTc) and heart rate-corrected Tp-Te (Tp-Tec) intervals combined with serum complement 1q/tumor necrosis factor-related protein 9 (CTRP9) levels for the development of ventricular arrhythmias (VA) after acute myocardial infarction (AMI). Methods A total of 156 patients with AMI were selected, VA occurred in 61 cases during hospitalization (VA group), and 95 cases (non-VA group) did not have VA. The QT and Tp-Te intervals were recorded on admission using a 12-lead ECG machine, and the QTc and Tp-Tec intervals were calculated. On the next day of admission, early morning fasting elbow venous blood was collected, centrifuged and serum was retained, and serum CTRP9 was measured by ELISA. We compared the general clinical data［including gender, age, BMI, smoking history, underlying diseases (hypertension, diabetes, hyperlipidemia)], disease-related data［including Killip classification on admission, left ventricular ejection fraction (LVEF) within 6 h after admission], laboratory examination data [including the four lipid items (TC, TG, HDL-C, LDL-C), blood creatinine (Scr), blood uric acid (UA), fasting plasma glucose (FPG) and serum CTRP9 level on the day after admission] and ECG examination data (including QTc, Tp-Tec interval) between the two groups. A multi-factor Logistic regression model was used to analyze the factors influencing the development of VA after AMI. Receiver operating characteristic (ROC) curves were used to analyze the predictive value of QTc, Tp-Tec intervals and serum CTRP9 levels in the development of VA after AMI. Results Compared with the non-VA group, the QTc and Tp-Tec intervals were significantly prolonged and serum CTRP9 levels were significantly lower in the VA group (all P<0. 05). No significant differences were found in the general clinical data and blood lipid, FPG, or Scr between the two groups (all P>0. 05). The ratio of Killip grade >Ⅱ in the VA group was higher than that in the non-VA group, while the LVEF was lower than that in the non-VA group (both P<0. 05). UA was higher in the VA group than in the non-VA group (P<0. 05). Multi-factor Logistic regression analysis showed that UA, QTc interval and Tp-Tec interval were all independent risk factors for the development of VA after AMI, while CTRP9 was an independent protective factor (all P<0. 05). ROC curve analysis showed that the area under the curve (AUC) for QTc and Tp-Tec intervals combined with serum CTRP9 levels in predicting VA after AMI was significantly higher than that of QTc interval, Tp-Tec interval, QTc interval + Tp-Tec interval, and CTRP9 in predicting VA after AMI (all P<0. 01). Conclusions Patients with VA after AMI had significantly longer QTc and Tp-Tec intervals and significantly lower serum CTRP9 levels. QTc and Tp-Tec intervals were independent risk factors for the development of VA after AMI, while CTRP9 was its independent protective factor. QTc, Tp-Tec intervals and serum CTRP9 levels all had some predictive value for the development of VA after AMI, but QTc and Tp-Tec intervals combined with serum CTRP9 levels had significantly higher predictive value for the development of VA after AMI. [ABSTRACT FROM AUTHOR]

目的 探讨 2 型糖尿病（T2DM）患者血清网膜素 1（Omentin-1）水平与骨代谢及氧化应激的关系。方法 选取 120例 T2DM患者，根据病情控制情况将其分为 A组（病情控制良好）68例和 B组（病情控制不良）52例。另选 择同期健康体检者60例作为对照组。采集受试者清晨空腹静脉血，采用ELISA法检测Omentin-1以及骨代谢指标骨 特异性碱性磷酸酶（BAP）、骨钙素（BGP）、抗酒石酸酸性磷酸酶（TrACP-5b），硫代巴比妥酸比色法测定血清丙二醛 （MDA），羟胺法测定超氧化物歧化酶（SOD）水平。比较三组血清Omentin-1水平、骨代谢指标及氧化应激指标的差异， 采用Pearson相关系数法分析T2DM患者血清Omentin-1水平与骨代谢指标及氧化应激指标的相关性。结果 A、B两 组血清Omentin-1水平均低于对照组，且B组低于A组（P均<0. 05）。与对照组比较，A、B两组血清BAP、TrACP-5b水 平升高，BGP水平降低（P均<0. 05）；与A组比较，B组血清BAP、TrACP-5b水平升高，BGP水平降低（P均<0. 05）。与对 照组比较，A、B两组血清MDA水平升高，SOD水平降低（P均<0. 05）；与A组比较，B组血清MDA水平升高，SOD水平降 低（P均<0. 05）。T2DM患者血清Omentin-1水平与BAP、TrACP-5b、MDA呈负相关（r分别为-0. 508、-0. 660、-0. 625， P<0. 05或<0. 01），与BGP、SOD呈正相关（r分别为0. 701、0. 589，P<0. 05或<0. 01）。结论 T2DM患者血清Omentin-1 水平降低，血糖控制不佳者下降更显著；Omentin-1水平与骨代谢异常及氧化应激反应有关，可能在糖尿病进展及骨 代谢异常中发挥作用。 [ABSTRACT FROM AUTHOR]

目的观察对精神分裂症合并糖尿病患者进行膳食干预的效果,并分析其影响因素。方法收集接受糖尿病膳食干预满1个月的精神分裂症合并糖尿病患者的相关资料,包括一般情况、疾病情况及膳食干预前后血糖、血压、血脂等指标。分析精神分裂症合并糖尿病患者膳食干预效果的影响因素。结果干预后患者空腹血糖(FPG)、糖化血清蛋白(GSP)、总胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)水平及BMI较干预前有所降低(P均<0.05)。FPG、血压达标率(分别为63.5%、51.3%)均较干预前提高(分别为22.8%、21.8%),P均<0.05;干预前后血脂达标率和体质量达标率差异无统计学意义。多因素Logistic回归分析显示,不服用降糖药、精神分裂症病程大于5年而糖尿病病程小于5年的患者血糖控制效果较好。结论糖尿病膳食干预可有效改善精神分裂症合并糖尿病患者的血糖、血压控制效果,血糖的控制效果与患者是否服用降糖药、精神分裂症和糖尿病病程有关。 [ABSTRACT FROM AUTHOR]

目的：探讨脑出血、脑梗死急性发作期患者血压、血脂、凝血纤溶功能差异及其临床意义。方法选取脑出血急性发作期患者52例（脑出血组）、脑梗死急性发作期患者48例（脑梗死组），另选体检健康者40例（对照组），均测量SBP、DBP，检测血浆TC、TG、LDL-C、HDL-C、脂蛋白a[Lp（a）]及抗凝血酶Ⅲ（AT-Ⅲ）、纤维蛋白原（FIB）、蛋白C（PC）、D-二聚体（D-D）。结果脑出血组、脑梗死组SBP和DBP均高于对照组（P均＜0．05）。脑出血组血浆TG、LDL-C及Lp（ a）水平均高于对照组，血浆TC、HDL-C水平均低于对照组；脑梗死组血浆TC、TG、LDL-C及Lp（ a）水平均高于对照组，血浆HDL-C水平低于对照组；脑出血组血浆TC、TG、LDL-C水平均低于脑梗死组；组间比较P均＜0．05。脑出血组、脑梗死组血浆FIB和D-D水平均高于对照组，血浆AT-Ⅲ水平均低于对照组；脑出血组PC活性高于脑梗死组及对照组；组间比较P均＜0．05。结论脑出血及脑梗死急性发作期患者均存在血压、血脂、凝血纤溶功能异常；脑梗死患者TC、TG、LDL-C水平及凝血纤溶亢进程度更高。 [ABSTRACT FROM AUTHOR]

目的探讨急性脑出血（ACH)患者血清血小板反应蛋白l(TSP-l)、血小板反应蛋白2(TSP-2)、基质金 属蛋白酶2(MMP-2)、基质金属蛋白酶9(MMP-9)水平变化及其与脑血肿量、脑水肿量的关系。方法选择ACH 患者95例为观察组，同期体检健康者100例为对照组。采用ELISA法检测两组血清TSP-1、TSP-2、MMP-2、MMP-9d 计算观察组脑血肿量及脑水肿量，分析血清TSP-1、TSP-2、MMP-2、MMP-9与脑血肿量、脑水肿量的关系结果观 察组血清TSP-l、TSP-2、MMP-2、MMP-9水平均高于对照组（P均<0.05)。观察组脑血肿量、脑水肿量分别为 (27. 23 ± 8.44)、(20. 99 ± 3. 65) mL0 Spearman相关性分析结果显示，观察组血清TSP-1与脑血肿量、脑水肿量均无 相关性(P均>0. 05) ;TSP-2与脑血肿量呈负相关(P = -0.639，P <0.05)，与脑水肿量无相关性（P >0.05); MMP-2 与脑血肿量无相关性（P >0. 05)，与脑水肿量呈正相关(r =0. 582，P <0. 05); MMP-9与脑血肿量、脑水肿量均呈正 相关(r分别为0.589、0.630，P均<0. 05)结论ACH患者血清TSP-1、TSP-2、MMP-2、MMP-9水平均升高，并与 患者脑血肿量及脑水肿量密切相关。 [ABSTRACT FROM AUTHOR]

目的　观察小剂量艾司氯胺酮联合右美托咪定在阻塞性睡眠呼吸暂停低通气综合征 (OSAHS) 患者清醒 纤维支气管镜引导气管插管 (AFOI) 中的应用效果。方法　全麻下行悬雍垂腭咽成形术的OSAHS患者60例, 按随 机数字表法分为对照组和观察组各30例。对照组静脉注射舒芬太尼, 观察组静脉注射艾司氯胺酮, 两组均同时予 右美托咪定泵注, 右美负荷量泵注完毕即开始纤维支气管镜引导插管。分别于入室安静10 min时 (T0 ) 、纤维支气管 镜置入鼻腔时 (T1 ) 、纤维支气管镜置入声门时 (T2 ) 、气管导管置入声门时 (T3 ) 记录两组患者心率 (HR) 、平均动脉压 (MAP) 、呼吸频率 (RR) 、脉搏血氧饱和度 (SpO2 ) 、Ramsay镇静评分 (RSS) 及T3时点呼气末二氧化碳分压 (PETCO2 ), 记 录两组患者插管时间、插管条件评分、患者舒适度评分、操作医师满意度评分、不良反应发生情况。结果　与同组T0 时点比较, 对照组T1 、T2时点HR、MAP下降, T1 ～T3时点RR、SpO2下降; 观察组T2时点RR、SpO2下降 (P均<0. 05) 。与 对照组同时点比较, 观察组T1 、T2 时HR升高 (P均<0. 05), T1 ～T3时MAP、RR、SpO2升高 (P均<0. 05) 。观察组T3时点 PETCO2低于对照组; 与同组 T0 时点比较, 两组 T1 ～T3时点 RSS评分均升高 (P均<0. 05) ; 两组同时点 RSS评分比较差 异均无统计学意义。两组插管时间、插管条件、患者舒适度和操作医师满意度差异均无统计学意义, 观察组低血压、 低氧血症及插管知晓发生率低于对照组 (P均<0. 05) 。结论　小剂量艾司氯胺酮联合右美托咪定在OSAHS患者清 醒气管插管中镇静效果较好, 且应用安全。 [ABSTRACT FROM AUTHOR]

Objective To observe the changes of cell proliferation and apoptosis of rat cardiomyocytes with nuclear respiratory factor-1 ( NRF-1 ) over-expression under hypoxia. Methods The rat cardiomyocytes H9C2 were divided into the NRF-1 over-expression group, empty vector group, and control group. The cells in tlie NRF-1 over-expression group and empty vector group were transfected with NRF-1 overexpressed lentivirus and empty vector lentivirus, respectively, and the control group was not treated. Cells of the three groups were placed into three gas incubator for anoxic culture (37 °C .1% O2, +5% CO2, + 94% N2 ) for 24 h. The real-time cell assay (RTCA) technology was used to observe cell proliferation level under normal and hypoxic conditions. Flow cytometry was used to detect the apoptosis rate, and qRT-PCR was applied to detect the relative expression of caspase-3 mRNA. Results At 24 and 48 h after hypoxia, the cells of NRF-1 over-expression group had a higher proliferation level than the control group and empty vector group. At 24 h after hypoxia, the apoptosis level of NRF-1 over-expression group decreased significantly , and the expression level of caspase-3 mRNA was lower as compared with that of the empty vector group and the control group ( both P <0. 05 ). Conclusion Over-expression of NRF-1 may reduce the apoptosis of cardiomyocytes under hypoxia condition, and enhance the viability of cardiomyocytes. [ABSTRACT FROM AUTHOR]

目的: 探讨ABO血型对乙肝后肝硬化食管胃底静脉曲张(EGV)患者病情的影响。方法研究对象为150例乙肝后肝硬化并发轻度EGV患者，其中ABO血型为A型47例、B型38例、O型40例、AB型25例。所有患者行规范抗病毒及保肝治疗，并随访2年。分析不同血型者EGV进展情况及门静脉主干内径、脾静脉内径、脾脏厚度。结果至随访截止日失访12例(其中A型5例、B型3例、O型2例、AB型2例)。进展至食管胃底静脉曲张破裂出血(EGVB)患者血型为A型7例、B型3例、O型4例、AB型12例，AB型所占比例高于A、B、O型(P均<0．05)。 AB型者治疗后门静脉主干内径、脾静脉内径、脾脏厚度均大于其他血型组(P均<0．05)。结论 AB型血乙肝后肝硬化患者EGV病情进展快，预后差，更容易发生EGVB。 [ABSTRACT FROM AUTHOR]

目的 观察全腹腔镜下胃转流手术治疗2型糖尿病的临床效果。方法 对29例2型糖尿病患者实施全腹腔镜下胃转流手术治疗,检测空腹及餐后2 h 血糖、糖化血红蛋白、C 肽、体质量指数(BMI),随访12个月进行疗效判断。结果 29例患者术后12个月空腹及餐后2 h 血糖、糖化血红蛋白、BMI 较术前均有不同程度下降,与手术前比较,P 均<0.05,C 肽与术前比较有所上升(P<0.05)。临床完全缓解 23 例(79.31%),改善6例(20.69%)。结论 全腹腔镜下胃转流手术治疗2型糖尿病近期临床疗效满意。 [ABSTRACT FROM AUTHOR]