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环状RNAs高度稳定，且不易被核酸外切酶降解，能够存在于外泌体和血液中。其在食管鳞癌、胃癌、结 直肠癌、肝细胞癌、胰腺导管癌中表达异常，具有微小RNA海绵、参与蛋白翻译、调控基因转录及剪切等功能，通过 多种信号通路在tl述消化系肿瘤发生、发展及转移中发挥重要调控作用，并且可以作为分子标志物用于消化道肿 瘤的诊断和预后判断。 [ABSTRACT FROM AUTHOR]

Objective To investigate the expression and mutations of DNA mismatch repair ( MMR) of Lynch syn-drome in the members of a Chinese Hui family. Methods The propositus was male, 37 years old, the forth generation, Hui nationality, had rectal poorly differentiated adenocarcinoma. There were six generations existing ( Hui nationality), and a total of 14 patients with colorectal cancer were found including 7 living cases. The peripheral blood and tumor tissue DNA was collected from 6 cases of patients and 5 healthy controls. The microsatellite instability ( MSI ) was detected through DNA sequencing, the expression of MMR protein was measured using immunohistochemistry, and MMR gene muta-tions was detected by PCR amplification. Results The MSI detection of tumor tissues in the family members demonstrated MSI-H.The immunohistochemistry showed that MLH1 protein was negative. Two new missense mutation sites ( c.264G>T and c.265G>T) in the first exon of MLH1 gene were found in 6 patients and 1 normal individual, and c.264G>T mu-tation led to early termination of MLH1 protein translation on this site. Conclusion There is MLH1 mutation in Hui family with Lynch syndrome, that is the missense muntation site c.264G>T in the first exon of MLH1 gene. [ABSTRACT FROM AUTHOR]

目的 系统评价质子泵抑制剂(PPI)使用与胃底腺息肉发病的关系. 方法 计算机检索CBM、CNKI、WANFANG Data、VIP Data、PubMed、Embase数据库中PPI使用与胃底腺息肉发病关系的相关文献,检索时间截至2015年2月20日. 由2名研究者根据纳入标准与排除标准独立筛选文献,采用纽卡斯尔-渥太华量表标准评价纳入文献质量,运用RevMan5.3及STATA11.0软件进行Meta分析. 结果 共纳入6个队列研究,研究对象34 701例,其中胃底腺息肉1 513例. Meta分析结果显示,PPI使用与胃底腺息肉的发病存在关联(RR=2.46,95% CI为1.37~4.43,P<0.01);亚组分析显示,PPI服用1年以上者胃底腺息肉发生率高于不足1年者(RR=3.12,95%为CI为1.72~5.67,P<0.05);且随着PPI服用时间延长,二者相关性有增加趋势. 敏感性分析表明,本Meta分析结果稳定可靠,Egger检验提示可能存在发表偏倚. 结论 PPI使用可能与胃底腺息肉发病有关. [ABSTRACT FROM AUTHOR]

目的：观察完整结肠系膜切除术（CME）治疗右半结肠癌的短期效果及安全性。方法选择右半结肠癌患者96例，随机分为CME组和传统手术组各48例，比较两组手术时间、术中出血量、淋巴结清扫数目、患者住院天数及术后并发症发生情况。结果两组均完整地切除了癌灶和系膜组织。两组手术时间、术中出血量、住院天数及术后并发症发生率比较，P均＞0．05；CME组术中淋巴结清扫数目为（17．7±1．9）枚，传统手术组为（15．8±2．4）枚，P＜0．05。结论 CME可以完整地切除癌灶和系膜组织，实现淋巴结清扫的最大化，且不增加手术风险及术后并发症发生率。 [ABSTRACT FROM AUTHOR]