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Objective To observe the changes of serum inflammatory factors, gut microbiota, and short chain fatty acids in feces of mice on a high-salt diet intragastrically administered Clostridium leptum. Methods Sixteen C57BL/6 male mice were randomly divided into the experimental group and control group. Mice in both groups were fed with a highsalt diet containing 8% NaCl for 16 weeks. Mice in the experimental group were gavaged with 2 mL Clostridium leptum sus‐ pension (109 CFU/mL) every other day, while mice in the control group were gavaged with 2 mL ultrapure water every oth‐ er day. Serum interleukin (IL) -1B, IL-6 and tumor necrosis factor-α (TNF-α) were detected by the ELISA. The fresh fe‐ cal samples were collected from mice for 16S rDNA high-throughput sequencing and short-chain fatty acids quantification. Results The serum levels of IL-1B, IL-6, and TNF-α in the experimental group were lower than those in the control group (all P<0. 05). The results of gut microbiota α-diversity and β-diversity analysis showed that the structure and diversity of gut microbiota in the experimental group significantly different from those in the control group. Compared with the control group, the relative abundance of Bacteroidetes and Proteobacteria in the experimental group increased, while the relative abundance of Firmicutes and Verrucobacteria decreased (all P<0. 05). At the species level, the Lactobacillus was significantly enriched in the experimental group, while the opportunistic pathogens such as Staphylococcus xylose and Staphylococcus lentus were significantly enriched in the control group. The concentrations of propionic acid, butyric acid and caproic acid in the experimental group were higher than those in the control group (all P<0. 05). Conclusion Clostridium leptum could reduce the levels of serum inflammatory factors, change the structure of gut microbiota and affect the metabolism of short chain fatty acids in the mice on a high-salt diet. [ABSTRACT FROM AUTHOR]

Abstract：Objective To investigate the effect of high-salt diet (HSD) on cognitive function of mice and to explore whether it is related to the disorders of gut microbiota. Methods Twenty C57BL/6 male mice were randomly divided into two groups：the ND group (n=10) and the HSD group (n=10) . The mice in the ND group were fed with ordinary maintenance fodder, and the mice in the HSD group were fed with high-salt fodder. They both were treated for 16 weeks. The cognitive function of mice was tested via Y maze and novel object recognition test, respectively, and we recorded the spontaneous response rate and preference rate data. Then fecal samples were collected for the total bacterial RNA extraction and 16S rDNA V4 fragment amplification by PCR method. We analyzed the differences of microbial composition between two groups by high-throughput sequencing. The relative expression levels of synaptophysin (SYP) mRNA in the brain tissues of two groups were detected by real-time fluorescence quantitative PCR method. Results The mice in the HSD group had significantly lower rate of spontaneous reaction and preference in both Y maze and novel object recognition test, as well as lower levels of SYP expression in brain tissues as compared with those of the ND group (all P<0. 05), and there were no significant differences in OTU number or α-diversity which included four indexes, Ace, Chao1, Shannon and Simpson, rspectively, between these two groups (all P>0. 05) . In the level of phylum, there were no significant differences in the the relative abundances of Birmicutes, Bacteroidetes, Proteobacteria, or Actinobacteria between these two groups (all P> 0. 05) . In the level of species, the relative abundances of Akkermansia muciniphila, Bacillus acidifaciens and Faecalibaculum rodentium were higher, while the relative abundance of Clostridium leptum was lower in the HSD group than in the ND group (all P<0. 05. Conclusion HSD impairs cognitive function in mice, which may be related to the disorders of gut microbiota. [ABSTRACT FROM AUTHOR]

目前，传统抗肿瘤药物的化疗效果不尽如人意。相对于新化学实体药物投入多、风险高且难度大，研发新 型释药系统具有成本低、周期短、见效快等特点。因此，研发新型释药系统成为近年抗肿瘤药物研究的热点。聚合物 胶束因其载药能力强、易于制备和能够实现主动靶向等优点得到研究者极大关注。聚乙烯己内酰胺—聚乙酸乙烯酯 —聚乙二醇接枝共聚物（Soluplus）是一种新型的两亲性载体材料，与其他载体材料一起制备成聚合物混合胶束，或同 时应用靶向给药、共载药策略，能够实现抗肿瘤药物减毒增效和逆转多药耐药的目的，从而提高传统抗肿瘤药物的化 疗效果。但目前 Soluplus 制剂仍局限于基础研究，其在处方工艺、临床转化等方面还需深入研究。 [ABSTRACT FROM AUTHOR]

糖尿病肾病作为糖尿病常见的微血管并发症, 是导致终末期肾功能衰竭的主要原因.目前研究表明, 甲状腺功能与糖尿病肾病的发生及发展有着密切的联系. 甲状腺激素具有潜在的肾脏保护作用,也可以调节葡萄糖代谢, 改善糖耐量异常和胰岛素抵抗. 甲状腺功能减退作为糖尿病肾病的独立危险因素, 可加剧糖尿病肾病患者的氧化应激和肾损伤, 补充甲状腺激素可改善糖尿病肾病的预后. [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的观察产褥期抑郁症患者血清IL-1β、11-2、11-6 、TNF-α 的水平变化， 分析其与抑郁严重程度的相关 性。方法选择97 例产妇进人研究，根据产后2 周时爱丁堡产后抑郁最表评分( EPDS 评分， ＞ 13 分或 ≤ 13 分） 分 为产裤期抑郁症组29 例（抑郁症组） 、非产裤期抑郁症组68 例（对照组). 两组于产后第6 周采用ELISA法检测血 清 IL-1β、IL-2、IL-6 、TNF-α ，分析血清炎症因子水平与EPDS 评分的相关性。结果抑郁症组血清11-6、TNF-α 水平 商于对照组(P 均< 0. 05) 。抑郁症组庄清IL-6、TNF-α 与EPDS 评分均呈正相关(r 分别为0. 62、0. 61, P 均< 0. 05) 。结论产桴期抑郁症患者血清IL-6、TNF-α 水平升商， 且11-6 、TNF-α 水平与抑郁症严重程度有关。 [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的观察慢性阻塞性肺疾病（COPD)伴阻塞性睡眠呼吸暂停综合征（OSAS)(患者（OS)肺动脉压力 及血清白细胞介素8(IL-8)、肿瘤坏死因子a(TNF-a)表达变化。方法 32例OS患者为OS组,40例单纯COPD 患者为COPD组，48例单纯OSAS患者为OSAS组。应用彩色多普勒超声测算三组肺动脉压力（PASP),抽取三组 空腹静脉血采用ELISA法检测血清白细胞介素8(IL-8)、肿瘤坏死因子-a(TNF-a)。结果 OS组、COPD组、OSAS 组 PASP 分别为（43. 99 ±13.48)、（38. 59 ±16.59)、（34. 48 ±5.91) mmHg,与 COPD 组、OSAS 组比较，OS 组 PASP 升高，血清IL-8及TNF-a水平升高(P均<0. 05)。OS组内合并肺动脉高压与非肺动脉高压者血清IL-8水平分别 为（14. 84 ± 8. 27)、（ 13. 89 ± 9.13 ) ng/L，二者比较，P < 0. 05 ; OS组内合并肺动脉高压与非肺动脉高压者血清 TNF-a水平分别为（28. 39 ± 10. 76)、（26.25 ± 10. 32) ng/L,二者比较，P <0. 05。结论与 COPD、OSAS 患者比较， OS患者PASP及血清IL-8、TNF-a水平均升高。血清IL-8、TNF-a水平升高可能与OS患者肺动脉高压的发生 有关。 [ABSTRACT FROM AUTHOR]