1. Hypoglycemic and hepatoprotective activity of Rosmarinus officinalis extract in diabetic rats.
- Author
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Ramadan KS, Khalil OA, Danial EN, Alnahdi HS, and Ayaz NO
- Subjects
- Alanine Transaminase metabolism, Alkaline Phosphatase metabolism, Animals, Aspartate Aminotransferases metabolism, C-Peptide metabolism, Diabetes Mellitus, Experimental enzymology, Diabetes Mellitus, Experimental pathology, Dose-Response Relationship, Drug, Hypoglycemic Agents isolation & purification, Insulin blood, Liver enzymology, Liver pathology, Male, Plant Extracts isolation & purification, Rats, Streptozocin, Diabetes Mellitus, Experimental drug therapy, Hypoglycemic Agents pharmacology, Liver drug effects, Phytotherapy, Plant Extracts pharmacology, Rosmarinus chemistry
- Abstract
The present study examined the effect of water extract (200 mg/kg body weight) of Rosmarinus officinalis L. in streptozotocin (STZ)-induced diabetic rats for 21 days. The hepatoprotective effects were investigated in the liver tissues sections. There was a significant increase in serum liver biochemical parameters (aspartate aminotransferase, alanine transaminase, and alkaline phosphatase), accompanied by a significant decrease in the level of total protein and albumin in the STZ-induced rats when compared with that of the normal group. The high-dose treatment group (200 mg/kg body wt) significantly restored the elevated liver function enzymes near to normal. This study revealed that rosemary extracts exerted a hepatoprotective effect. The results indicate that the extract exhibits the protective effect on tissues and prove its potentials as an antidiabetic agent.
- Published
- 2013
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