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This study was carried out on 15 Holstein cows divided into 3 groups of 5. Group 1 was the control, group 2 had traumatic reticuloperitonitis (TRP), and group 3 had traumatic pericarditis (TP). Comparison between the groups included clinical, hematological, biochemical, and ultrasonographic changes. TRP cows had arched backs, a sharp decrease in milk yield, and a reluctance to move, with abduction of the fore limbs. TP cows had edema of the brisket and submandibular region, with jugular vein distension and pulsation. TRP cows had a significant increase in PCV, leukocytes, and neutrophils, and a significant decrease in RBC, hemoglobin, and lymphocytic counts, as compared to the control group. TP cows had significant erythrocytopenia, leukocytosis, neutrophilia, monocytosis eosinopenia, and basopenia, and a significant decrease in the hemoglobin, lymphocytes, eosinophils, and basophils as compared to the controls. Serum AST, SLT, LDH, and CPK were significantly higher in the TP group than they were in the control and TRP groups. It was concluded that TP cows had more significant changes in hematology, biochemistry, ultrasonography, and histopathology than the TRP cows. [ABSTRACT FROM AUTHOR]