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Background: The accuracy of test results is closely related to the clinical diagnosis and treatment, while drugs may interfere with the test results. When the abnormal value of results occured, it is important to analyze the drug-related interferential factors. Objective: To remind clinicians and pharmacists to eliminate interference factors when finding abnormal results by recording the cause analysis process of a patient with abnormally elevated creatinine. Methods: In this case of an abnormally elevated creatinine in a patient treated with vancomycin, the clinical pharmacist analyzed the reasons of patients' creatinine elevation, especially vancomycin-associated kidney injury and other interfering factors of combination drugs in the tests. Results: The clinical pharmacist Clinical pharmacists found that acute kidney damage was not caused by vancomycin, the “real killer” was the etamsylate interference factors in laboratory test of creatinine value. This discovery enabled the patient's antibiotic treatment to proceed smoothly. Conclusions: As a clinical pharmacist, it is necessary to understand the medication situation of patients and be familiar with the common types of "drug interference detection". With these advantages in drug knowledge, clinical pharmacists can assist clinicians to identification and judgment of adverse drug reactions, and play an important role in the treatment of patients.