1. Indirect prediction of fetal lung maturity. Value of ultrasonographic colonic and placental grading.
- Author
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Loret de Mola JR, Judge N, Entsminger C, DeViney M, Muise KL, and Duchon MA
- Subjects
- Adult, Anthropometry, Colon diagnostic imaging, Colon embryology, Diabetes, Gestational complications, Female, Fetal Organ Maturity, Humans, Lung diagnostic imaging, Placenta diagnostic imaging, Placenta physiology, Predictive Value of Tests, Pregnancy, Lung embryology, Ultrasonography, Prenatal methods
- Abstract
Objective: To correlate fetal morphometrics with studies of fetal lung maturity., Study Design: One hundred six patients undergoing amniocentesis for fetal lung maturity studies were examined prospectively. Eighty-four patients were normal (79%), and 22 were diabetic (21%). Fetal morphometrics were obtained prior to amniocentesis. The fetal colon and placenta were graded. Discriminant analysis was used to identify variables that were predictive of a mature lecithin/sphingomyelin ratio and the presence of phosphatidylglycerol (PG). All patients delivered within 48 hours of amniocentesis., Results: In the normal group, 28 (33%) fetuses had a grade 3 colon, which was 68% sensitive and 98% specific for a mature amniocentesis. A grade 3 colon was the single best predictor of a mature amniocentesis (P < .001). Twenty-five (29%) fetuses had a grade 3 placenta, which was 64% sensitive and 96% specific for a mature amniocentesis (P < .005). Diabetes did not influence colonic grading since a grade 3 colon was present in seven (32%) patients (47% sensitivity and 100% specificity for PG) (P < .02). Interexaminer and intraexaminer variability for the study was excellent, kappa = 1.0 (P < .001)., Conclusion: Colonic and placental stage 3 grading are reliable and reproducible ultrasonographic scales that can help predict the findings of fetal lung maturity studies.
- Published
- 1998