1. Antimicrobial Activity of 8-Hydroxyquinoline and Transition Metal Complexes
- Author
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Virapong Prachayasittikul, Supaluk Prachayasittikul, Somsak Ruchirawat, Sujittra Srisung, and Thummaruk Suksrichavalit
- Subjects
Pharmacology ,biology ,Chemistry ,Stereochemistry ,Antimicrobial ,medicine.disease_cause ,biology.organism_classification ,Enterococcus faecalis ,chemistry.chemical_compound ,Staphylococcus aureus ,Ampicillin ,medicine ,Potency ,Growth inhibition ,Candida albicans ,Bacteria ,medicine.drug - Abstract
Heterocyclic compounds like 8-hydroxyquinoline (8HQ) and derivatives have been found in natural products and therapeutics. Herein 8HQ and metal complexes of 8HQ-5-substituted (X) uracils, X = I, NO2 (1-6) were investigated for their antimicrobial potency. The complexes 1-6 exhibited growth inhibition against many strains of gram-positive and gram-negative bacteria with minimum inhibitory concentrations (MICs) of 575.71-718.76 mu M. The investigated compound 8HQ was shown to be a very strong antimicrobial agent with the MIC of 27.58 mu M that comparable to ampicillin (MIC 26.93 mu M), the reference drug. The activity of 8HQ mostly was observed for resistant pathogens, gram- positive bacteria e.g. Staphylococcus aureus, Enterococcus faecalis and diploid fungus, Candida albicans. The findings reveal 8HQ as the very potent antimicrobial agent and a series of 8HQ transition metal complexes as novel antimicrobials as well as the applications of 8HQ for the design and synthesis of new and potential therapeutic lead compounds.
- Published
- 2013