1. Seizures with Pentylenetetrazoll indling Cause a Decrease in the Number of Pyramidal Neurons in the Rat Hippocampus
- Author
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Kocacan, Suleyman Emre, Sefil, Fatih, Elibol, Ebru, Altunkaynak, Berrin Z., Acar, Meryem Dilek, Bagirici, Faruk, Kaplan, Süleyman, and Ondokuz Mayıs Üniversitesi
- Subjects
nervous system ,convulsants ,pentylenetetrazole ,kindling ,neurologic ,neurological disorders ,neurotoxicity ,stereology ,food and beverages ,epilepsy ,neurotoxicity syndromes ,neurotoxin diseases ,seizures - Abstract
Kaplan, Suleyman/0000-0003-1477-5002 WOS: 000387093200007 OBJECTIVE: To investigate the effects of pentylenetetra-zole (PTZ) kindling on the number of pyramidal neurons in the rat hippocampus. STUDY DESIGN: Using unbiased stereology, we calculated total pyramidal neuron numbers in the CA1, CA2, and CA3 areas and the whole hippocampus after PTZ-induced kindling. The estimation and the analysis of the number of hippocampal pyramidal cells (areas of CA1-3) were done with the optical fractionator technique, which is a stereological counting technique. RESULTS: Stereological analysis showed that the total number of pyramidal neurons in the whole hippocampus and the number of pyramidal neurons in CA1 were significantly lower in kindled rats as compared to the controls (p0.05). CONCLUSION: PTZ-induced seizures cause a decrease in the amount of pyramidal neurons in the CA area of the rat hippocampus.
- Published
- 2016