1. Evidence of increased hypoxia signaling in fetal liver from maternal nutrient restriction in mice
- Author
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Bethany N. Radford and Victor K. M. Han
- Subjects
Male ,Offspring ,Physiological ,Intrauterine growth restriction ,Nutritional Status ,Gestational Age ,Biology ,Fetal Hypoxia ,Pediatrics ,Andrology ,03 medical and health sciences ,Mice ,0302 clinical medicine ,Pregnancy ,030225 pediatrics ,medicine ,Animals ,Developmental ,Adaptation ,skin and connective tissue diseases ,Fetus ,BTG2 ,Fetal Growth Retardation ,Animal ,Gestational age ,Gene Expression Regulation, Developmental ,Maternal Nutritional Physiological Phenomena ,Hypoxia (medical) ,medicine.disease ,Newborn ,Adaptation, Physiological ,Disease Models, Animal ,Gene Expression Regulation ,Liver ,Animals, Newborn ,Prenatal Exposure Delayed Effects ,Pediatrics, Perinatology and Child Health ,Disease Models ,Animal Nutritional Physiological Phenomena ,Female ,FKBP5 ,sense organs ,medicine.symptom ,030217 neurology & neurosurgery ,Signal Transduction - Abstract
BACKGROUND: Intrauterine growth restriction (IUGR) is a pregnancy condition where fetal growth is reduced, and offspring from IUGR pregnancies are at increased risk for type II diabetes as adults. The liver is susceptible to fetal undernutrition experienced by IUGR infants and animal models of growth restriction. This study aimed to examine hepatic expression changes in a maternal nutrient restriction (MNR) mouse model of IUGR to understand fetal adaptations that influence adult metabolism. METHODS: Liver samples of male offspring from MNR (70% of ad libitum starting at E6.5) or control pregnancies were obtained at E18.5 and differential expression was assessed by RNAseq and western blots. RESULTS: Forty-nine differentially expressed (FDR
- Published
- 2020