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Background: Injuries to the medial structures of the knee are common in multi-ligamentous knee injuries (MLKIs), which account for 0.02% of orthopedic injuries each year. The most common medial structure involved is the superficial medial collateral ligament (sMCL) with possible additional injury to the posterior oblique ligament (POL) and deep medial collateral ligament (dMCL). There has been little evidence for the superior management of these structures regarding the use of repair or reconstruction to reproduce overall knee function. Although reconstruction may provide more valgus stability postoperatively, the use of sMCL repair over reconstruction may be superior at reestablishing native anatomic alignment and kinematic relationships of the knee while also preserving proprioception and providing similar valgus stability. Indications: Surgical repair of medial structures is typically indicated for third-degree injuries, bony avulsions, tibial plateau fracture, intra-articular entrapment of the end of the ligament (Stener-type lesions), or anteromedial stability. They are particularly indicated in the elite athlete who presents with excessive valgus laxity due to valgus knee loading, external rotation, or combined force vectors. Technique Description: This surgical technique video demonstrates an open, medial-sided femoral and tibial approach to repair proximal and distal medial knee structures in the setting of MLKIs using case examples of a Stener lesion and a combined sMCL, POL, and medial patellofemoral ligament tears. Results: Repair of sMCL injuries has been reported to show favorable healing, knee stability, and function. Discussion/Conclusion: The use of fixation of the sMCL to its anatomical attachment points offers similar valgus stability and improved functional and patient-reported outcomes when compared with sMCL reconstruction. Patient Consent Disclosure Statement: The author(s) attests that consent has been obtained from any patient(s) appearing in this publication. If the individual may be identifiable, the author(s) has included a statement of release or other written form of approval from the patient(s) with this submission for publication.

Venous thromboembolism (VTE), including deep venous thrombosis (DVT) and pulmonary embolism (PE), represents a substantial healthcare challenge. Provoked and unprovoked DVT cases carry distinct risks and treatment considerations. Recognizing the limitations of this classification, molecular markers may enhance diagnostic precision and guide anticoagulation therapy duration relying on patient history and risk factors. This preliminary, open-label, prospective cohort study was conducted including 15 patients (10 provoked DVT and 5 unprovoked DVT) and a control group of healthy plasmatic subjects. Plasma levels of 9 biomarkers were measured at diagnosis (baseline, day 0, and D0) and after 30 days (day 30-D30). Patient demographics, clinical data, and biomarker concentrations were analyzed. Serum concentrations of D-dimer, von Willebrand factor, C-reactive protein, and Anti-Xa were elevated in DVT groups at D0 compared to controls. No significant differences were observed between the provoked and unprovoked groups on the day of diagnosis and 30 days later. Over 30 days, the provoked group exhibited significant biomarker changes related to temporal assessment. No significant differences were noted in the biomarker profile between provoked and unprovoked DVT groups. This study is indicative of the concept of individualized thrombosis assessment and subsequent treatment for VTE. Larger cohorts are warranted to validate these findings and further define the most appropriate use of the molecular markers.

Background: Patellar tendon ruptures presenting in a chronic setting are rare events that impose technical surgical challenges due to proximal retraction of the patella, quadriceps muscle atrophy and contracture, and peripatellar adhesions. Various reconstruction techniques have been described using different grafts and fixation methods; however, there is a paucity of reported outcomes and there is no consensus on standard of care. Indications: The patient is a 36-year-old man who presented with a failed patellar tendon reconstruction 14 months after his initial surgery (performed 1 year after the initial injury) with functional weakness and loss of extension. The patient was indicated for a revision patellar tendon reconstruction due to persistent functional limitations. Technique Description: The revision patellar tendon reconstruction was performed with gracilis and semitendinosus tendon autografts harvested from the ipsilateral limb. Hardware was removed from the initial graft tunnels in the tibial tubercle and patella. Patellar height was estimated using fluoroscopic measurement of the contralateral patellar tendon length. The graft is first passed through the patellar tunnel, and the individual limbs of the graft are then both placed through the tibial tubercle tunnel. A sternal wire in a figure-of-eight configuration was used to progressively distalize the patella to match the native patellar height, and the graft was then tensioned and secured together. Results: The patient regained full range of motion at 2-year follow-up and was able to return to work and activities without functional limitations. Recent case series also using ipsilateral hamstring tendon autograft for chronic patellar tendon reconstruction report improved patient outcome scores, normal Insall-Salvati index, improved quadriceps strength, and high levels of patient satisfaction. Discussion/Conclusion: Chronic patellar tendon ruptures are technically challenging to treat, especially in the context of revision of a failed reconstruction. The technique presented in this video may aid orthopaedic surgeons in treating this rare but debilitating injury. Given the lack of high-quality evidence, future studies are needed to explore graft choices, graft fixation techniques, and postoperative protocols. Patient Consent Disclosure Statement: The author(s) attests that consent has been obtained from any patient(s) appearing in this publication. If the individual may be identifiable, the author(s) has included a statement of release or other written form of approval from the patient(s) with this submission for publication.

Category: Ankle; Sports Introduction/Purpose: Syndesmotic injury in an athletic population is associated with a prolonged ankle disability after an ankle sprain and often requires a longer recovery than a lateral collateral ligament injury. Although several imaging tests are available, diagnosing syndesmotic instability remains challenging. The main objective was to determine the diagnostic accuracy of conventional ankle computed tomography (CT) scans with the joint in external rotation and dorsiflexion and compare it with that of conventional ankle CT scans in a neutral position. Methods: Between September 2018 and April 2021, this prospective study consecutively included adults visiting the foot and ankle outpatient clinic with a positive orthopedic examination for acute syndesmotic injury. Participants underwent 3 CT scan tests. First, ankles were scanned in a neutral position. Second, ankles were scanned with 45° of external rotation, dorsiflexion, and extended knees. Third, ankles were scanned with 45° of external rotation, dorsiflexion, and flexed knees. Three measurements, comprising rotation (measurement a), lateral translation (measurement c), and anteroposterior translation (measurement f) of the fibula concerning the tibia, were used to diagnose syndesmotic instability in the 3 CT scans. Magnetic resonance imaging was used as a reference standard. The area under the curve (AUC) was used to compare the diagnostic accuracy, and Youden’s J index was calculated to determine the ideal cutoff point. Results: Images obtained in 68 participants (mean age, 36.5 years; range, 18-69 years) were analyzed, comprising 36 syndesmotic injuries and 32 lateral collateral ligament injuries. The best diagnostic accuracy occurred with the rotational measurement a, in which the second and third CT scans with stress maneuvers presented greater AUCs (0.97 and 0.99) than the first CT scan in a neutral position (0.62). The ideal cutoff point for the stress maneuvers was 1.0 mm in the rotational measurement and reached a sensitivity and specificity of 83% and 97% for the second CT scan with extended knees and 86% and 100% for the third CT scan with flexed knees, respectively. Conclusion: Conventional ankle CT with stress maneuvers has excellent performance for diagnosing subtle syndesmotic rotational instability, as it shows a greater AUC and enhanced sensitivity at the ideal cutoff point compared with ankle CT in the neutral position.

Category: Bunion; Midfoot/Forefoot Introduction/Purpose: Minimally invasive surgery (MIS) Chevron-osteotomy for HV treatment offers a surgical alternative to open surgery with minimal surgical dissection and a hypothetical decreased risk for soft-tissue complications. During this procedure, there is a concern regarding the injury to the blood supply of the 1st-metatarsal-head. The objective of this study was to assess the incidence of injuries: (1) to the soft-tissue envelope around the first metatarsal head complex and, (2) to the blood supply of the first metatarsal head and also by using Micro-CT, (3) looking for safe zones close to the first metatarsal head to perform MIS Chevron osteotomy. We hypothesized that the MIS Chevron-type osteotomy procedure would preserve the soft-tissue envelope of the first-metatarsal-head complex and the blood supply of the 1st-metatarsal-head. Methods: Sixteen HV deformity cadaveric specimens were used to perform MIS Chevron-type osteotomy of the first metatarsal head. Anatomical dissection of all specimens was then performed to assess macroscopic injury to the first metatarsal head complex soft-tissue structures, including Extensor Hallucis Longus (EHL) tendon, Extensor Hallucis Brevis (EHB) tendon, Flexor Hallucis Longus (FHL) tendon, Flexor Hallucis Brevis (FHB) tendon, Abductor Hallucis tendon, Adductor Hallucis tendon, Sesamoid complex, Dorsolateral and Dorsomedial digital branches of the first toe and the Dorsomedial digital branch to the second. Macroscopic injuries were classified using a calibrated digital caliper. Any chondral damage to the first metatarsal head was quantified in mm². To assess the amount of first metatarsal head blood supply, specimens were perfused with 200 ml of a low viscosity radiopaque polymer, MV 117 (Flowtech), preoperatively, followed by Micro-CT assessment. Descriptive statistics and percentages were utilized for categorical data. Results: We did not find injuries in the EHL, EHB, FHL, Abductor-Hallucis, and Adductor-Hallucis tendons. We found a 2mm injury in the FHB tendon in one specimen. No injuries were found in the Dorsomedial and Dorsolateral nerves of the first-toe, the Dorsomedial-nerve of the second-toe, and Medial branch of the dorsomedial-nerve of the first-toe. In 3 cases, we found an injury on first-metatarsal-head (1mm) due to the passage of the K-wire and, in 1 case, due to the inadvertent passage of the drill (4.41mm). Macroscopically and using Micro-CT, we did not observe injuries in the First-Dorsal-Metatarsal-Artery (FDMA), Lateral-Dorsal-Branch of FDMA, and Plantar-Metatarsal-Artery. Micro-CT helped estimate a safe distance to finish the proximal exit of Chevron-osteotomy (25mm from the most distal point of the first metatarsal head). Conclusion: In this study, the minimally invasive Chevron osteotomy for treating HV seems to be a technically safe procedure, presenting a low rate of iatrogenic injuries with a low degree of severity. In addition, using Micro-CT promoted a better visualization of the microvasculature that nourishes the first metatarsal head. We observed that a proximal distance of 25 mm from the most distal part of the first metatarsal head could be a safe place to finalize the Chevron osteotomy, minimizing the risk of injury to the blood supply of the first metatarsal head.

Category: Ankle; Sports Introduction/Purpose: A ligament-centered analysis is currently incorporated in the assessment of joint stability in malleolar fractures. Although several imaging tests are available, in the setting of acute isolated non-displaced posterior malleolar fractures Bartoníček/Rammelt types II and IV diagnosing syndesmotic instability remains challenging. The objective of this multi-center cross- sectional study was to evaluate the syndesmotic and fracture instability using conventional ankle CT with external rotation and dorsiflexion in the setting of acute, isolated non-displaced Bartoníček and Rammelt type II posterior malleolar fractures. Methods: Between March 2018 and September 2022, a consecutive sample of 123 individuals with an ankle sprain were assessed for eligibility. In total, 33 participants met the inclusion criteria. All participants underwent a CT scan (CTSM), comprising a first phase with the ankles in a neutral position, then a stress phase with the ankles in external rotation and dorsiflexion and semiflexed knees. Investigators used the patterns of ligament tear found at MRI and instability at CTSM to classify all participants into West Point grades I, IIA, IIB, or III. Mann-Whitney test was used to test the differences in the numerical variables between injured and uninjured syndesmoses. The Spearman correlation tested the strength of the association between the tibial joint surface involved in posterior malleolus fracture and syndesmotic instability. Results: In MRI reading parameters two patterns of syndesmotic ligament injury predominated. A completely torn AITF and IO ligaments and a completely torn AITF was combined with a partially torn IO. Regarding the deep layer of the deltoid ligament, participants were classified as normal, strained and partially torn. In CT scan reading parameters in the neutral phase, the median difference of 0.2 mm in d measurements between injured and uninjured syndesmoses was not statistically significant (P = 0.057). During the stress phase, the injured and uninjured syndesmoses had distinct behavior, and the 2.3 mm median difference for d measurement was statistically significant (P < 0.0001). Conclusion: The conventional computed tomography with external rotation and dorsiflexion represent a reproducible and accurate diagnostic option for the detection of syndesmosis instability and fracture instability in acute isolated posterior malleolar fractures Bartonícek and Rammelt type II.

Category: Trauma; Ankle Introduction/Purpose: The importance of the deltoid ligament in the congruency of the tibiotalar joint is well known. The current trend is to repair it in cases of acute injuries in the context of ankle fractures, however, there is no information on how it should be reconstructed. The objective of this study was to compare different deltoid ligament repair types in an ankle fracture cadaveric model. Methods: 16 cadaveric foot-ankle-distal tibia specimens were used to conduct the study. All samples were prepared as a supination external rotation ankle fracture model. An axial load and cyclic axial rotations were applied on every specimen using a specifically designed frame. This test was performed without deltoid injury, with deltoid injury and finally with the ligament reconstructed. The reconstruction was performed in 4 different ways (anterior, posterior, middle, combined) using 4 specimens per group. Medial clear space (MCS) was measured for each condition on simulated weight-bearing and gravity stress radiographs. Reflective markers were utilized in tibia and talus, registering through a motion analysis system the kinematics, to record the tibiotalar uncoupling. Statistical analysis was performed using the SPSS software. Results: In all cases, the MCS increased significantly on gravity stress radiographs after damaging the deltoid ligament. There was no increase in the MCS on load radiographs. After repair, in all cases, the MCS was normalized. Kinematically, after damage the tibiotalar uncoupling increased significantly, decreasing after repair. All repairs significantly corrected the tibiotalar uncoupling, observing a significantly increased coupling effect (increased stiffness) with the combined repair. Conclusion: Our results show that deltoid repair recovers the tibiotalar coupling mechanism in an ankle fracture model. We suggest that the ideal repair should aim to repair the middle aspect of the deltoid ligament. The combined repair may lead to postoperative stiffness. Clinical studies are needed to prove these results and show clinically improved outcomes.

Category: Hindfoot; Sports Introduction/Purpose: Zadek's procedure is a surgical option to treat insertional Achilles tendinopathy(IAT). This procedure consists of a closing wedge osteotomy of the calcaneus with biomechanical consequences. Great modifications in the hindfoot alignment can result in poor functional outcomes for athletes. Additionally, some authors stated that Zadek osteotomy is a good choice for patients with IAT associated with cavovarus foot. This study aims to analyze the hindfoot alignment and the parameters related to Haglund's syndrome after Zadek's osteotomy using a virtual surgical simulation by specific software. The authors hypothesize that the Zadek is an effective technique to decompress the Achilles tendon against the Haglund deformity without major modifications in the alignment. Methods: A total of 20 WBCT scans of patients with IAT were included. The WBCT images were run through the Foot & Ankle module of Disior's BonelogicTM software, creating a 3D virtual model. With this 3D model built into this software, 20 virtual Zadeck osteotomies standardized with a 10 mm resection wedge were performed using the virtual osteotomy module of Bonelogic®. The Calcaneal Inclination angle (sagittal view)7; Talocalcaneal angle (sagittal view)8; Talocalcaneal angle (axial view)8; Saltzman angle (45 degrees view)9; Saltzman angle (20 degrees view)9; Hindfoot moment arm angle;10 Hindfoot angle10; Fowler Philips angle11 and the calcaneal length7 were measured before and after the virtual osteotomy. These results were compared and statistically analyzed. Results: A virtual Zadek osteotomy was realized in 20 WBCT from patients with an insertional Achilles tendinopathy. Most of the patients were female, and the mean age was 55 years. There were significant statistical differences in the average of the calcaneal length (79 mm to 73 mm), Fowler Philips angle (57º to 43º), calcaneal pitch ( 24º to 20º ), sagittal talocalcaneal angle (55º to 47º ), and the hindfoot moment arm angle (20 º to 21,8º). The axial talocalcaneal angle, Saltzman view 45 º and 20 º, and Hindfoot moment arm showed subtle modifications. Conclusion: The virtual analysis of Zadek's osteotomy decreased the Fowler Philips angle, shortened the calcaneus, and modified the alignment in the sagittal view. It suggests that Zadek's procedure reduces the bone impingement with Achilles and the Achilles push. The effect of this osteotomy in Hindfoot Alignment was subtle, modifying only the sagittal plane.

Category: Sports; Arthroscopy Introduction/Purpose: Rotational ankle injuries are frequent and mostly benign. However, chronic pain and residual instability following an index rotational trauma can happen. The diagnostic elucidation of the pain source is challenging, with ligamentous insufficiency, osteochondral injuries, and impingement/arthritis representing potential causes for symptoms. The prevalence and pattern of the residual isolated or combined ligamentous ankle instability following rotational injuries are not entirely elucidated in the literature. In this prospective cohort study, we aimed to assess the frequency of combined ligamentous instability (lateral, medial, and syndesmotic) in patients with chronic ankle pain (>6 months) following rotational ankle injuries that failed conservative treatment and underwent surgical treatment. We also aimed to assess improvement in patient-reported outcomes (PROs) following treatment of the diagnosed conditions. Methods: IRB-approved prospective cohort study. We included patients with history of chronic pain (>6 months) following a rotational ankle injury, with clinical signs of combined ligamentous instability of at least two ligamentous complexes (lateral, medial, and syndesmotic), and that failed conservative treatment (>3 months). All patients underwent surgical treatment. Diagnostic arthroscopic assessment was performed. Syndesmotic instability was considered positive if a metallic sphere of 3mm could be inserted in the anterior syndesmotic space. Deep deltoid instability was confirmed with a “pass-through sign” when a 4.0mm shaver could be introduced in the medial gutter. Lateral ankle instability was confirmed with a positive rotatory drawer test under fluoroscopic assessment. Presence of isolated or combined ligamentous instability was noted and patients received appropriate open surgical treatment for the confirmed ligamentous insufficiencies. Presence of associated osteochondral injuries, peroneal pathology and anterior bony impingement was also recorded. PROs were collected pre-operatively and at most recent follow-up. Results: A total of 27 patients were included (9 males/18 females), mean age 35.9 years (range, 18-68) and average BMI 31.3kg/m 2 (CI, 28.1-34.5). Eighty-nine percent had ankle sprains, and 11% rotational ankle fractures treated conservatively. Intraoperative assessment demonstrated positive lateral, medial, and syndesmotic instability in respectively 96%, 81%, and 78% of the patients. Most common combined instabilities were: 59% multidirectional (all three complexes), 19% rotational (medial+lateral), 15% anterolateral (lateral+syndesmotic), and 4% anteromedial (medial+syndesmotic). Isolated lateral instability was present in only one patient (4%). Peroneal tendon pathology, osteochondral injuries and anterior bony impingement were found in respectively 67%, 19%, and 26% of the patients. The average postoperative follow-up was 22.2 months (3-39 months). Significant improvements in VAS (P=0.0024), PROMIS Pain Interference (p=0.024), and EFAS scores (p=0.022) were observed. Conclusion: In this prospective cohort study, combined multiligament instability was extremely frequent in patients with chronic pain following rotational ankle injuries. Ninety-six percent of patients had confirmed intraoperative instability of at least two of the three ankle ligamentous complexes. Multidirectional (lateral, medial, and syndesmotic) (49%), rotational (lateral and medial) (19%), and anterolateral (syndesmotic and lateral) (15%) instabilities were the most frequent injury patterns. Following ligamentous repair/reconstruction, significant improvements in PROs were observed at an average follow-up of 22-months. Our study highlights that the diagnosis of residual multiligament ankle instability should be considered in patients with chronic ankle pain following rotational injuries.

Category: Ankle; Sports Introduction/Purpose: Syndesmotic injuries and residual chronic subtle distal tibiofibular syndesmotic instability (DTFSI) are relatively common injuries, especially in athletes prone to suffering high ankle sprains. The diagnosis of subtle DTFSI remains challenging, with a high prevalence of false-negative results using conventional non-invasive clinical-radiographical diagnostic tools. The current gold standard for diagnosis, arthroscopy, is a surgical operation, which is invasive and, therefore, not ideal. Weightbearing Computed-Tomography (WBCT) has emerged as a possible dynamic non-invasive alternative diagnostic option, with proven high diagnostic accuracy for syndesmotic incisura area measurements in major DTFSI. Our study aimed to assess the capability of semiautomatic weight-bearing computed tomography (WBCT) syndesmotic incisura area in diagnosing subtle chronic syndesmotic instability. Methods: In this diagnostic case-control study, patients with suspected unilateral chronic subtle DTFSI underwent bilateral standing weight-bearing CT (WBCT) before surgical treatment. All patients had gold-standard arthroscopic assessment for DTFSI, introducing a 3mm diameter arthroscopic sphere into the syndesmotic incisura for diagnosis. Bilateral syndesmotic incisura areas were measured 10mm proximally to the apex of the distal tibia articular dome using a semiautomatic measurement algorithm. Two tangent lines marked the anterior and posterior borders of the syndesmotic incisura to the anterior and posterior edges of the distal tibia and fibula. Once borders were marked, the incisura area was automatically calculated by the software based on a Hounsfield units (HU) contrast algorithm. A HU threshold of 200HU was utilized. Measurements were done independently by two fellowship-trained readers. Comparisons between injured and control ankles were made using Student T-test or Wilcoxon, according to normality. Measurements' reliability was assessed with the Intraclass Correlation Coefficient (ICC). Results: From an initial sample of 32 patients, 20 patients (12 female) with arthroscopically confirmed DTFSI (11 right sides) with a mean age of 31.7 years (range 18 to 55 years) and a mean BMI of 30.35kg/m² (SD +/-8.29 kg/m²) were included in the study. All patients had a history of an old ankle sprain 6 to 182 months before the assessment, and athletic lesions were reported in 53% of the population. ICCs were above 0.98 for both intra and interobserver reliability. The average syndesmotic area was 96.91mm 2 (SD +/-27.9mm 2 ) in injured ankles compared to 84.61mm 2 (SD +/-26.9 mm 2 ) in uninjured ankles. The difference between injured and non-injured tibiofibular areas was 12.31mm 2 (95%CI: 9.04-15.58mm 2 ), which was shown statistically significant (p < 0.001; effect size: 1.43). Conclusion: In this case-control study, we assessed the accuracy of semiautomatic WBCT syndesmotic incisura area measurements in diagnosing subtle chronic DTFSI. We found an increased syndesmotic area in injured ankles that reached statistical significance. Due to the minimal differences between injured and uninjured contralateral ankles, larger cohorts would likely solidify this study's findings further. The use of external rotation stress, volumetric assessment, distance, and coverage maps could increase the diagnostic accuracy in DTFSI. However, automatic area measurements have a higher overall reproducibility and applicability in the clinical setting, which could help providers make therapeutic decisions.

Category: Midfoot/Forefoot; Bunion Introduction/Purpose: Interpositional arthroplasty (IPA) is a motion-preserving surgery in patients with advanced hallux rigidus. Literature displays several complications after the procedure including transfer metatarsalgia, cock-up deformity and infection. In a finite element model, shortening of the first metatarsal was associated with increased plantar pressure on lateral rays during gait. Additionally, there are reports of a positive correlation between first metatarsal shortening after hallux valgus surgery and transfer metatarsalgia of the second, third and fourth metatarsophalangeal joints. The goals of this study were to report the outcomes and complications of IPA using acellular dermal allograft (IPA-ADA) as well as study the changes in the length of the proximal phalanx of the hallux (P1) and the first metatarsal (M1) following the procedure. Methods: In this IRB-approved retrospective study, we assessed patients who underwent IPA-ADA in a single academic institute during the period 2019-2022. All patients’ demographic data, surgical details, complications, and patient-reported outcomes (PROs) were extracted. On standing conventional anteroposterior (AP) foot views, we measured the lengths of the first metatarsal (M1), the second metatarsal (M2), the proximal phalanx of the big toe (P1) and the entire length of the hallux (HX). The ratio of M1/M2 and P1/HX were calculated. The first metatarsophalangeal joint space was measured at the medial and lateral aspects of the joint on the AP view. All measurements were recorded pre-operatively, at six weeks follow-up and at the final follow-up. Descriptive statistics were performed, comparison between groups was performed using analysis of variance (ANOVA) or Kruskal Wallis test according to data normality. The Dunn-Bonferroni test was then performed for pairwise group comparisons.A p-value < 0.05 was considered significant. Results: Eleven patients were included, 9 being females (81.81%). Six were hallux rigidus Coughlin grade III (54.55%) and 5 were grade IV (45.45%). The average age was 59 years (SD±6.78) and the body mass index (BMI) was 26 (SD±4.79). At the final follow- up, there was significant shortening of the first ray in comparison to the pre-operative length evidenced by lower M1/M2 (82.63 SD±2.29 versus 75.42 SD±5.1; p=0.001) and P1/HX ratio 53.38 ± 2.29 versus 48.98 SD ± 7.92; p=0.001). Although there was no significant difference between M1/M2 at 6 weeks and at the final follow-up (p=0.716), there was a significant negative correlation between follow-up length and M1/M2 (r= -0.76, p=0.003). Follow-up was (19.95 months; range 3-39). Complications and PROs are listed in Figure 1. Conclusion: Interposition arthroplasty using dermal allograft for HR is associated with progressive shortening of the first ray at the level of the first metatarsal as well as the proximal phalanx. Although the study did show shortening of the first ray, the small sample size didn't allow for a correlation between this shortening and complications such as transfer metatarsalgia and cock-up toe deformity. The potential shortening should be considered in the selection of patients, particularly in the setting of an already short first metatarsal or when simultaneous Akin/Moberg osteotomy is planned.

Introduction: Ticagrelor might reduce infarct size by exerting a more potent antiplatelet effect or by promoting a potential conditioning stimulus in ST-elevation myocardial infarction (STEMI) patients. Pre-infarction angina (PIA) is an effective preconditioning stimulus that reduces ischemia-reperfusion injury. Because little is known on the interaction of PIA in STEMI-patients loaded with ticagrelor, we sought to determine if patients loaded with ticagrelor had improved clinical outcomes as compared to clopidogrel and to study if it is modulated by the presence of PIA. Methods: From 1272 STEMI patients submitted to primary percutaneous coronary intervention and treated with clopidogrel or ticagrelor from January 2008 to December 2018, 826 were analyzed after propensity score matching. Infarct size was estimated using peak creatine kinase (CK) and troponin T (TnT), and clinical impact was evaluated through cumulative major cardiac and cerebrovascular events (MACCE) at 1-year follow-up. Matched patients and their interaction with PIA were analyzed. Results: Patients loaded with ticagrelor had lower peak CK [1405.50 U/L (730.25-2491.00), P < .001] and TnT [3.58 ng/mL (1.73-6.59), P < .001)], regardless of PIA. The presence of PIA was associated with lower CK ( P = .030), but not TnT ( P = .097). There was no interaction between ticagrelor loading and PIA ( P = .788 for TnT and P = .555 for CK). There was no difference in MACCE incidence between clopidogrel or ticagrelor loading ( P = .129). Cumulative survival was also similar between clopidogrel or ticagrelor, regardless of PIA ( P = .103). Conclusion: Ticagrelor reduced infarct sizes independently and without a synergic effect with PIA. Despite reducing infarct size, clinical outcomes were similar across both groups.

Background: Tibiotalocalcaneal arthrodesis is a well-established procedure to treat some hindfoot diseases. Currently, the most used implants are retrograde intramedullary nails and locking plates combined with lag screws, but there are few articles comparing differences regarding the complications. Methods: We have retrospectively analyzed the medical records and the radiographs of patients older than 18 years who underwent this procedure in our service between 2005 and 2019 through retrograde intramedullary nails or lateral locking plates and compression screws with at least 12 months of follow-up and with no history of osteomyelitis in these bones. Results: We evaluated a total of 67 patients; of these, 48 received retrograde intramedullary nail implants and 19 received locking plates and compression screws. The overall mean age was 48 years; the median follow-up time was 64.3 months. The complication rate was 60.4% for the intramedullary nail procedure and 52.6% for the locking plate combined with compression screws procedure. Conclusion: No significant differences were found in the complication rates between the 2 implants. Level of Evidence: Level V, Case series

Category: Midfoot/Forefoot; Bunion Introduction/Purpose: Kim et al.'s simulated weight-bearing CT (WBCT) investigation classifying first metatarsal (M1) pronation and its relationship to the metatarso-sesamoid complex suggested a high prevalence (87.3%) of M1 hyper-pronation in hallux valgus (HV). These authors' conclusions have prompted a marked increase in M1 derotation (supination) in HV surgical correction. No subsequent study confirms their M1 pronation values, and two recent WBCT investigations suggest lower normative M1 pronation values. The objectives of our WBCT study were to (1) determine M1 pronation distribution in HV, (2) define the hyperpronation prevalence compared to preexisting normative values, and (3) assess the relationship of M1 pronation to the metatarso-sesamoid complex. We hypothesized identifying a high HV M1 head pronation distribution, but not as high as suggested by Kim et al. Methods: We retrospectively identified 88 consecutive feet with HV in our WBCT dataset and measured M1 pronation with two previously validated methods, the Metatarsal Pronation (MPA) and α angles. Similarly, using two previously published methods defining the pathologic pronation threshold, we assessed our cohort's M1 hyper-pronation prevalence, specifically (1) the upper value of the 95% confidence interval (CI95) and (2) adding 2 standard deviations at the mean normative value (2SD).The position of the sesamoids relative to the crista on the axial plane (sesamoid grading) was assessed according to Talbot et al. classification secondarily adapted by Yildirim et al. on CT scan (Figure).Normality of different variables was assessed using the Shapiro-Wilk test and distribution histogram. Two groups were compared using Student's t-test for normal, and Mann-Whitney U test for non- normal variables. P values less than .05 were considered significant. Results: The mean MPA was 11.4+/-7.4 degrees (IC95%:9.9-13.0; Range: -2.3-37.1) in our HV population and the α angle was 16.2+/-7.4 degrees (IC95%:14.7-17.7; Range: 2.8-43.2). A strong positive correlation was found between these two variables (ρ=0.82;r2=0.79;P

Category: Bunion; Lesser Toes; Midfoot/Forefoot Introduction/Purpose: Hallux valgus deformity (HVD) is a complex 3D distortion that involves varus, dorsiflexion and pronation of the first metatarsal. Deformity is usually assessed by conventional 2D measurements such as hallux valgus and intermetatarsal angle. Weightbearing CT (WBCT) 3D Distance Mapping (DM) and Coverage Mapping (CM) allow assessment of relative positioning between opposing articular surfaces, providing information in regards to articular coverage and joint subluxation, that can potentially influence development of arthritic degeneration and symptoms, as well as dictate outcomes. The aim of this study was to develop a DM and CM algorithm to assess metatarsophalangeal (MTP) and metatarso-sesamoid (MS) joint interaction in HVD patients and compare it to healthy controls. We hypothesized that significant MTP and MS joints lateral subluxation would be observed. Methods: In this IRB-approved study, we included 9 HVD patients (mean age 37.1y; 6F/3M) and 5 controls (mean age 39y; 4F/1M) that underwent foot WBCT foot. Bone segmentation of WBCT images for the first and second metatarsals, first and second proximal phalanxes as well as tibial and fibular sesamoids was performed using specific software. Joint interaction with DM and CM of the first and second MTP joints, as well as MS joints were calculated. The surface of the MTP joints were divided in a 2x2 grid using principal axes to provide a more detailed analysis. DMs were color coded to facilitate data interpretation (Figure). Blue color represented expected normal joint interaction (distances from 1 to 3 mm), yellow/red color symbolized increased joint distances (distances from 3 to 5 mm) and pink color indicate completely uncovered articular areas (distances >5mm). Comparisons were performed with independent t-tests/Wilcoxon. P values

Category: Midfoot/Forefoot Introduction/Purpose: Weight-Bearing Computed Tomography (WBCT) measurements represent a reliable tool for radiographic analysis of the first ray, including multiplanar assessment in the axial, sagittal, and coronal planes. WBCT can allow for more reliable studies of pathologies, such as Hallux Rigidus (HR), which permits several anatomical points to be evaluated for a correct clinical-radiographic diagnosis. In addition, new software with an advanced semi-automated segmentation system obtains semi-automatic 3D measurements of WBCT scan data sets, minimizing the errors in reading angular measurements. The study`s objective was (1) to assess the reliability of WBCT computer-assisted semi-automatic imaging measurements in HR, (2) to compare semi-automatic to manual measurements in the setting of HR, and (3) to compare semi-automatic measurements between a pathologic (HR) group and a control standard group. Methods: This was a retrospective, IRB approved study of patients with Hallux Rigidus deformity. The sample size calculation was based on the Metatarsus Primus Elevatus (MPE). A control group consisting of 20 feet without HR and a pathologic group consisting of 20 feet with HR was necessary for this study. All WBCT manual and semiautomatic 3D measurements were performed using the following parameters: (1) first Metatarsal-Proximal Phalanx Angle (1stMPP) (sagittal plane), (2) Hallux Valgus Angle (HVA), (3) first to second Intermetatarsal Angle (IMA), (4) Hallux Interphalangeal Angle (IPA), (5) first Metatarsal Lengths (1stML), (6) second Metatarsal Length (2ndML), (7) first Metatarsal Declination Angle (1stMD), (8) second Metatarsal Declination Angles (2ndMD), and (9) MPE. The semiautomatic 3D measurements were performed using the Bonelogic Software. The differences between pathologic and control cases were assessed with a Wilcoxon test and P

Neonatal lupus is a rare entity, secondary to placental transfer of antibodies from mothers with immune-mediated conditions. While pulmonary involvement is common in lupus, its incidence in neonates is extremely rare, with very few cases being reported in the literature. The authors report a case of a neonate whose mother was diagnosed with systemic lupus erythematosus, with a prenatal diagnosis of third-degree atrioventricular block. While initially admitted in the neonatal intensive care unit with no need for organ support, he presented progressive respiratory failure, initially attributed to sepsis. Favorable clinical progression after pacemaker placement allowed ventilatory weaning, but respiratory failure was again apparent. Chest computer tomography revealed areas of ground-glass lesions, raising the suspicion for lupus pneumonitis. He was started on immunoglobulin and corticosteroids, with clinical improvement. The authors consider this case to be relevant due to the rarity of acute lupus pneumonitis in neonates, alerting that it must be considered a differential diagnosis in neonates with prolonged ventilator dependency.

Category: Ankle; Sports; Trauma Introduction/Purpose: Although there are several imaging options for diagnosing the syndesmotic injury, a fundamental question that guides treatment remains unanswered. Syndesmotic instability is still challenging to diagnose correctly, and syndesmotic disruption and true syndesmotic instability should be differentiated. Currently, imaging tests quickly diagnose severe syndesmotic instability but have difficulty in diagnosing mild and moderate cases. Recently, weight-bearing CT (WB-CT) has emerged as a new modality for the examination of syndesmosis; however, studies have shown that WB-CT is not superior to conventional computed tomography (CT), and axial loading has no benefit for the diagnosis of instability. This study aims to investigate which index test between a CT in a neutral position (CTNP) and a new CT test with stress maneuvers (CTSM) can more accurately diagnose syndesmotic instability. Methods: This diagnostic accuracy-test study consecutively selected individuals older than 18 years with an orthopedic evaluation suspected for acute syndesmotic injury. The accuracy of the index tests (CTNP and CTSM) were examined using magnetic resonance imaging (MRI) as the reference standard. The external rotation and dorsiflexion of the ankle guided the stress maneuvers. Comparison measurements between the injured syndesmosis and the uninjured contralateral side of the same individual investigated syndesmotic instability regarding the translational and rotational relationship between the fibula and tibia. Sensitivity, specificity, positive likelihood ratio (+LR), and negative likelihood ratio (-LR) value analyzed the diagnostic accuracies of the index tests. Results:: The population included in this study consisted of 64 patients (34 men, 30 women; age range 18-69 years; mean age 35 years). The CTNP exam showed a sensitivity of 18.7% (95% CI, 8 to 35), a specificity of 97% (95% CI, 85 to 99), a +LR of 6.3 (95% CI, 0.8 to 50), and a -LR of 0.8 (95% CI, 0.7 to 0.9). The CTSM exam showed a sensitivity of 91% (95% CI, 76 to 99), a specificity of 94% (95% CI, 80 to 98), a +LR of 15.4 (95% CI, 4 to 59), and a -LR of 0.09 (95% CI, 0.03 to 0.28). The CTSM reflected superior accuracy because the +LR was higher than that of the CTNP, and the confidence interval (CI) for the +LR does not contain 1. Conclusion:: Nevertheless, CTNP is used routinely, this study showed that the test was insufficient for the correct diagnosis, as it presented low sensitivity result. A CTNP with a normal result was not able to exclude syndesmotic instability. The use of the stress maneuver with external rotation and dorsiflexion was a decisive factor for the correct diagnosis, considering that the CTSM exhibited high sensitivity and captured a significantly greater number of true positive cases than the CTNP. This study confirmed CTSM as an accurate method for diagnosing syndesmotic instability and opened a new approach to investigate mild and moderate challenging cases.

Category: Hindfoot; Midfoot/Forefoot; Other Introduction/Purpose: Recent literature has established the middle facet of the subtalar joint as a reliable and accurate marker of pronounced peritalar subluxation (PTS) in Adult Acquired Flatfoot Deformity (AAFD) patients. The Foot and Ankle Offset (FAO) has also been accepted as a more complete and three-dimensional (3D) measurement of foot collapse and hindfoot valgus. To date, no assessment has been made regarding the relationship between the severity of the AAFD and the amount PTS measured at the middle facet. The objective of this study was to investigate the correlation between these variables. We hypothesized that direct positive linear correlation would be found, with significantly increased middle facet joint incongruence and subluxation in patients with more pronounced hindfoot valgus and foot collapse. Methods: In this IRB-approved retrospective comparative study, we included 76 feet (42 left, 35 right) with symptomatic AAFD who underwent standing weightbearing CT (WBCT) as standard baseline assessment of their foot deformity. One blinded fellowship-trained foot and ankle surgeon with more than 10 years of experience performed measurements using multiplanar reconstruction (MPR) WBCT images. Manual measurements of subluxation and incongruence of the middle facet were performed at the anteroposterior midpoint of the articular facet. Semiautomatic calculation of the FAO was performed after 3D coordinate harvesting of the weightbearing points of the first, fifth metatarsal and calcaneus as well as the center of the ankle. Correlation of FAO severity and subluxation/incongruence of the middle facet was assessed by Spearman’s correlation and bivariate analysis. Paired Wilcoxon was utilized to compare FAO values in congruent (0% subluxation), subluxated (1-99% subluxation) and dislocated middle facets. P-values 20) (p

Category: Ankle Arthritis; Ankle; Hindfoot; Other Introduction/Purpose: Sinus tarsi and Subfibular impingement are considered the main causes of lateral foot pain in patients with Adult Acquired Flatfoot Deformity (AAFD). They are considered important markers in the spectrum of progressive peritalar subluxation (PTS) in patients with AAFD. Recent literature has also highlighted the use of the Middle Facet of the subtalar joint as a more accurate indicator of PTS. The objective of this study was to assess the relationship between lateral impingement and middle facet PTS. Our hypotheses were that patients with sinus tarsi and subfibular impingement would demonstrate more severe PTS than patients with no impingement, and that subfibular impingement would represent a better indicator of pronounced deformity when compared to sinus tarsi impingement. Methods: In this retrospective comparative Cohort Study, we included 110 AAFD patients that underwent standing weightbearing CT (WBCT) as a standard baseline assessment of their foot deformity. The presence or absence of sinus tarsi and subfibular impingements, as well as the incongruence angle and percentage of subluxation of the middle facet of the subtalar joint, were manually measured on multiplanar reconstruction (MPR) WBCT images by a blinded fellowship-trained foot and ankle surgeon. Descriptive statistics were used to describe the rate of sinus tarsi and subfibular impingement as well as mean values for middle facet incongruence angle and subluxation. Wilcoxon test was used to compare the values of PTS at the middle facet in patients with or without sins tarsi and subfibular impingement. A partition prediction model was used to assess the values of middle facet PTS that would foresee a higher risk for lateral impingement. P-values

Category: Hindfoot; Ankle; Midfoot/Forefoot Introduction/Purpose: Multiple surgical techniques are used in the correction of Adult Acquired Flatfoot Deformity (AAFD). Assessment of the efficacy of a surgical treatment in the correction of the deformity is usually performed by clinical evaluation and conventional radiographic imaging. Weightbearing CT (WBCT) allows a more reliable and multiplanar evaluation of AAFD. The Foot and Ankle Offset (FAO) is a WBCT biometric semi-automatic measurement that gauges the relative positioning between the foot tripod and the center of the ankle joint. This study aimed to investigate the efficacy of surgical treatment in correcting AAFD, comparing preoperative and postoperative FAO measurements. We hypothesized that surgical treatment would provide significant correction of the deformity, centering the tripod of the foot underneath the ankle joint. Methods: In this prospective comparative study, 21 adult patients (22 feet) with flexible AAFD were included, mean age 55 (range, 23-81) years, 13 females and eight males. Patients underwent preoperative and postoperative standing WBCT examination. Three-dimensional coordinates (X, Y and Z planes) of the foot tripod (weightbearing point of the first and fifth metatarsals and calcaneal tuberosity) and center of the ankle (apex of the talar dome) were harvested by two independent and blinded observers. The FAO was automatically calculated from the harvested 3D coordinates by dedicated software. Data regarding the surgical technique used was recorded. Patient Reported Outcomes (PROs) were collected preoperatively and postoperatively at a mean follow-up of 22 (range, 8-36) months. Pre and postoperative FAO measurements were compared by paired T-tests. Multivariate analysis was used to assess the influence of surgical procedures in the amount of FAO correction. P-values of less than 0.05 were considered significant. Results: We found excellent intra (0.98) and interobserver reliability (0.96) for FAO measurements. The mean preoperative FAO was 10.4 (95% CI, 8.5 to 12.1). There was a significant correction of the deformity postoperatively (p

Category: Ankle; Ankle Arthritis; Arthroscopy; Sports Introduction/Purpose: Chronic subtle distal tibiofibular syndesmotic instability (DTFSI) is relatively common, and consequences of undiagnosed injuries can be devastating. Diagnosing acute and chronic injuries is challenging, and the most commonly used diagnostic tools are physical exams, conventional radiographs and bilateral CT, and MRI. Arthroscopic assessment, an invasive method, is currently considered the gold standard. Weightbearing CT has just emerged as an excellent dynamic non-invasive diagnostic test. Recent literature highlighted the accuracy of syndesmotic incisura area measurements in diagnosing subtle DTFSI. The aim of our study was to develop and validate the use of a novel automatic 3D volumetric assessment of the incisura, and to compare the measurements between patients with surgically confirmed DTFSI and controls. Methods: In this IRB-approved case-control study, patients with suspected unilateral chronic subtle DTFSI underwent bilateral standing weightbearing CT (WBCT) examination before surgical treatment. DTFSI was confirmed by arthroscopic assessment. We also included control patients that underwent WBCT tests for forefoot related problems and no history of syndesmotic injuries. The syndesmotic incisura volume (mm3) was measured starting at the level of the ankle joint to two proximal points, 10 and 15mm proximally to the joint. A 3D automatic measurement algorithm composed of automated segmentation of the distal tibia and fibula and recognition of the incisura volume based on Hounsfield units (HU) assessment was performed. Measurements were compared between DTFSI patients and controls. A partition prediction model, ROC curves and area under the curve (AUC) were performed to assess the diagnostic accuracy of the automatic volumetric analysis to detect DTFSI. P-values of less than 0.05 were considered significant. Results: In this preliminary report, four patients with DTFSI and seven controls were included. Mean value and 95% CI for 3D Syndesmotic Incisura volumetric measurements at 10 and 15mm points: 1457 mm3 (1233 to 1680)/2241 mm3 (1951 to 2531) for controls, and 1679 mm3 (910 to 2447)/2425 mm3 (1408 to 3443) for patients with DTFSI (p-values of respectively 0.35 and 0.55).When comparing injured and uninjured DTFSI ankles, volume measurements at 10 and 15mm points were increased on injured ankles, with a Hodges-Lehmann difference of respectively 287 mm3 (p=0.19), and 186 mm3 (p=0.31). The partition model demonstrated that the volume of the first 10mm was the best predictor of DTFSI, with only 3% chances of DTFSI when the incisura volume was below 1291 mm3 (AUC=0.71). Conclusion: Our study aimed to describe and validate the use of a novel automatic 3D volumetric measurement of the distal tibiofibular incisura in patients with chronic subtle ankle syndesmotic instability and controls. Our preliminary results demonstrated increased volumes on injured ankles when compared to contralateral uninjured ankles and controls. Measurements performed within the first 10mm length of the syndesmosis were found to predict better the presence of syndesmotic instability, with a volume of 1291 mm3 representing an important diagnostic threshold. Automatic 3D WBCT volumetric measurements may represent a useful non-invasive diagnostic tool for subtle and chronic syndesmotic instability.

Category: Lesser Toes, Midfoot/Forefoot Introduction/Purpose: The treatment of lesser toe metatarsophalangeal joint (MTPJ) arthritis is challenging, and surgical options are scarce. The use synthetic polyvinyl alcohol hydrogel implants in the treatment of the lesser MTPJ arthritis may provide symptomatic relief. An essential technical limitation is that only 8 mm and 10 mm implants are currently available, potentially limiting their use in the lesser metatarsals. The objective of this cadaveric study was to evaluate the average dimensions of the lesser metatarsal heads using CT scans and anatomical dissections, and to perform progressive drilling of the heads, aiming to assess the largest implant dimension that would be safely introduced into the metatarsal heads, preserving an adequate bone rim and providing stability to the implant. Methods: Ten cadaveric specimens were used. Surgical procedures were performed by a single fellowship-trained foot and ankle surgeon. Height and width of all lesser metatarsals were measured on CT and during anatomic dissection. Heads of all five metatarsal were exposed. Sequential reaming of the 2nd to 4th metatarsals with 0.5 mm increments was then performed. Once a minimum 6 mm reaming was obtained, the thickness of the surrounding bone rim (dorsal, plantar, medial and lateral) was measured using a precision caliper after each reaming increment. Maximum reaming size, largest implant inserted (8 mm or 10 mm), and the presence of failure of the metatarsal head or instability of the implant were recorded. Metatarsal head sizes were compared by Wilcoxon Rank Sum Test. Multiple regression analysis evaluated measurements that influenced the maximum reaming and implant size. Correlation between CT and anatomical measurements were evaluated by intraclass correlation (ICC). P-values of less than 0.05 were considered significant. Results: CT and anatomical measurements demonstrated significant correlation (ICC range, 0.63 to 0.85). Mean values for height and width of the metatarsal heads were respectively: second (14.9 mm and 9.9 mm), third (14.8 mm and 8.8 mm), fourth (14.0 mm and 8.7 mm) and fifth (12.3 mm and 9.3 mm). All the second, third and fourth metatarsal heads could be safely drilled up to 7.5 mm, preserving an intact bone rim. At 80% of the time, the heads could be safely drilled up to 8.0 mm. Height of the metatarsal heads was the only factor to significantly influence the size of maximum reaming and implant introduced. In respectively 20%, 40% and 50% of the second, third, and fourth metatarsal heads, neither 8 mm nor 10 mm PVAH implants could be used. Conclusion: Our cadaveric study found that the even though the majority of the lesser metatarsal heads could be safely drilled up to 8 mm, the smallest PVAH implant size currently available in most countries (8 mm) could be inserted in most of the second, but only in about half of the third and fourth metatarsal heads. The remaining bone rim around inserted implants was considerably thin, usually measuring less than 1 mm. In order to optimize the use PVAH in lesser metatarsal heads, smaller implant options are needed.

Category: Hindfoot Introduction/Purpose: Peritalar subluxation comprises part of the three-dimensional and complex distortion that occurs in patients with adult-acquired flatfoot deformity (AAFD) and is characterized by subluxation of the hindfoot through the triple joint complex. It is traditionally graded on weightbearing computed tomography (WBCT) coronal plane images, depending upon the degree of angulation and subluxation of the posterior facet of the subtalar joint. In this case-control study, we describe a new marker of peritalar subluxation represented by the amount of subluxation and joint incongruence of the middle facet of the subtalar joint. We hypothesized that the amount of joint subluxation and incongruence at the middle facet would be significantly increased in patients with AAFD when compared to controls. Methods: Case-control study, we included 30 patients with stage II AAFD (19 females/11 males), mean age 52.2 (range, 29 to 81) years, and 30 controls (18 females/12 males), mean age 49.3 (range, 28 to 83) years, that underwent WBCT as part of the evaluation of their foot condition. Age and gender were statistically similar in both groups. The amount of subluxation of the subtalar joint at the middle facet (% of uncoverage) and angle of joint incongruence, both measured at the midpoint of its longitudinal length, was measured in coronal WB CBCT images by two independent and blinded fellowship-trained foot and ankle surgeons. A second set of measurements was performed after one month (wash-out period). Intra- and interobserver reliability were assessed by Pearson/Spearman’s and Intraclass Correlation Coefficient (ICC), respectively. Comparison was performed using Paired Student T-Test or each pair Wilcoxon rank sum test. P-values lower than 0.05 were considered significant. Results: We found overall good to excellent intra- (range, 0.90-0.95) and interobserver reliability (range, 0.75-0.93) for the measurements. We found significantly increased subluxation of the subtalar joint at the middle facet in patients with AAFD, with a mean value for middle facet uncoverage of 45.3% (95% CI, 40.5% to 50.1%), when compared to 4.8% (95% CI, 0% to 9.6%) in controls (p

Category: Ankle, Trauma Introduction/Purpose: Precise diagnosis of distal tibiofibular syndesmotic injury is challenging and a gold standard diagnostic test has still not been established. Tibiofibular clear space identified on radiographic imaging is considered the most reliable indicator of the injury. The Cotton test is the most widely used intraoperative technique to evaluate the syndesmotic integrity although it has its limitations. We advocate for a novel intra operative test using a 3.5 mm cortical tap. Methods: Tibiofibular clear space was assessed in nine cadaveric specimens using three sequential fluoroscopic images. The first image was taken prior to the application of the tap test representing the intact and non-stressed state. Then, a 2.5 mm hole was drilled distally on the lateral fibula, and a 3.5 mm cortical tap was then threaded in the hole. The tap test involved gradually advancing the blunt tip against the lateral tibia, providing a tibiofibular separation force (intact, stressed). This same stress was then applied after all syndesmotic ligaments were released (injured, stressed). Measurements were compared by one-way ANOVA and paired Student’s t-test. Intra and inter-observer agreements were evaluated by intraclass correlation coefficient (ICC). P-values 6 mm as diagnostic for syndesmotic instability, the tap test demonstrated a 96.3% sensitivity and specificity, a 96.3% PPV and NPV and a 96.3% accuracy in diagnosing syndesmotic instability. Conclusion: Our cadaveric study showed that this novel syndesmotic instability test using a 3.5 mm blunt cortical tap is a simple, accurate and reliable technique able to demonstrate significant differences in the tibiofibular clear space when injury was present. It could represent a more controlled and stable low-cost alternative to the most used Cotton test.

Category: Basic Sciences/Biologics Introduction/Purpose: Posterior tibial tendon dysfunction (PTTD), the most common cause of flatfoot deformity in adults, is more frequent in the female gender with peak incidence in the sixth decade of life. Multiple risk factors - intrinsic and extrinsic - and associated systemic conditions have been described in the literature. Genetic predisposition secondary to hyperexpression of genes related to hormonal metabolism, particularly the estrogens, may play a role in the pathogenesis of this disease acting in association with behavioral and endogenous risk factors. Methods: 202 female patients over the age of 40 were included in the study (N = 202). They were then divided into 2 different groups (n = 101): cases and controls. We defined as cases postmenopausal women with symptomatic PTTD, diagnosed by clinical and MRI examinations. Females with similar epidemiology, but clinically asymptomatic and with normal MRI evaluation for the posterior tibial tendon were defined as controls. Oral mucosa epithelial cells were collected from the patients and genomic DNA was extracted from the samples. The SNPs for the ER1 (XbaI and PvuII) and ER2 (AluI) genes were assessed by PCR-RFLP. Results: Patients with SNP Xbal genotype xx had 2.38 higher estimated risk (p = 0,029) in developing PTTD, when compared to patients with the other genotypes. No associations were found for the SNP PvuII and AluI. Conclusion: The present study demonstrates that patients with the Xbal single nucleotide polymorphism of estrogen receptor 1 gene have higher risk of developing posterior tibial tendon dysfunction.

Category: Hindfoot; Other Introduction/Purpose: The radiographic measurement of hindfoot alignment (HA) suggested by Saltzman, worldwide accepted, uses the medial aspect of the foot as the sagittal axis. When defining the medial face of the foot as its axis, the adduction and abduction deformities of the forefoot are disregarded, making it necessary to rotate the ankle internally or externally to acquire the radiographic image according to Saltzman protocol. The emergence of weight-bearing computed tomography (WBCT) allowed immeasurable advancements for a better understanding of the joints relations of the foot and ankle under stress. Previous studies using this technology adopted several sagittal axes to measure HA. Our hypothesis is that the adduction observed in the forefoot of the cavovarus feet illusively accentuates the real deformity of the hindfoot. Methods: Two evaluators calculated the HA of twenty-eight feet - 14 cavovarus and 14 neutral or slightly valgus (control group) - in three different sagittal axes (second metatarsal axis, calcaneus - second metatarsal axis and talar dome axis). Measurements were compared by Student's t-test after normality test by Shapiro-Wilk method. Observers' agreement was evaluated by intraclass correlation coefficient (ICC). P-values

Category: Basic Sciences/Biologics; Hindfoot Introduction/Purpose: Implant-related artifact (IRA) represents an important limitation in Computed Tomography (CT) assessment of osteotomy and fracture healing, bone-implant integration, and success of fusion procedures. Metallic implants are the most used in foot and ankle surgery and are recognized as important IRA generators. Absorbable and bio-integrative (BI) implants are attractive options for bone fixation when postoperative CT imaging is likely, particularly in procedures with higher risk for nonunion. However, the literature comparing IRA with metallic and BI implants is scarce. The objective of this study was to assess the degree of IRA around metallic and BI cannulated screws. Our hypothesis was that BI implants would demonstrate significantly decreased IRA around the inserted screws. Methods: In this cadaveric/CT imaging study, 2 below-knee specimens were used. Medial displacement calcaneal osteotomy was performed through a 5-cm long lateral heel approach. Calcaneal tuberosity was displaced medially by 10mm and fixed provisionally with 2 parallel K-wires under fluoroscopic guidance. Specimens were fixed with two headless 4.0 millimeters cannulated screws, either metallic or BI. Cone-beam CT imaging of both specimens was acquired following osteotomy screw fixation (120kVp, 5.5mA, 0.25mm isotropic). Using a dedicated software, the overall dispersion of Hounsfield units (HU) in a 3D cube of 30mm edge length was assessed. Four HU lines were then traced parallel to the screws, crossing the osteotomy site. Lines 1, 2, 3 and 4 were positioned respectively: In close proximity, over, inside the cannulation and away from the implant. The HU dispersion in these lines was measured and compared between metallic and BI implanted specimens, using T-tests/Wilcoxon analysis. P-values

Category: Hindfoot; Midfoot/Forefoot Introduction/Purpose: Lateral impingements, subdivided into Sinus Tarsi (STI), Talo-Fibular (TFI), and Calcaneo-Fibular (CFI) impingements, appear to be associated with the Peritalar Subluxation (PTS) component of the Progressive Collapsing Foot Deformity (PCFD). This is not yet confirmed, as the chronological place of the different types of lateral impingements in PTS is unknown. It is also unclear whether STI are associated with PTS or Midfoot Abduction. Our primary objective was to assess the amount of PTS in STI, TFI and CFI. Our secondary objective was to determine the position of STI among the PTS and Midfoot Abduction deformities. We hypothesized that STI and TFI will be associated with a lower amount of PTS than CFI and that STI will be part involved in both PTS and Midfoot Abduction deformities. Methods: A retrospective study including 72 PCFD assessed with Weight Bearing Computed Tomography (WBCT) was realized. Patients under 15 or with a previous history of surgery were excluded. Lateral impingements were assessed on WBCT images and subdivided as STI, TFI and CFI. Both direct and indirect signs of impingement were considered positive. The amount of PTS was assessed by the percentage of uncoverage and the incongruence angle of the Middle Facet (MF). Midfoot-Abduction was assessed by Talonavicular coverage angle and global foot deformity by Foot and Ankle Offset (FAO). These data were collected by two independent observers and one performed a blinded second assessment. Interobserver and Intraobserver reliabilities were determined using unweighted Cohen's kappa values for lateral impingements and using intraclass correlation coefficients for the measurements. Impingement groups were compared using Student's T-tests for normal, and Mann-Whitney for non-normal variables. Results: Interobserver and Intraobserver reliabilities ranged from substantial to almost perfect for all assessments. STI was present in 84.7%, TFI in 65.2% and CFI in 19.4% of PCFD cases. PCFD with STI showed significant increases of MF uncoverage (p=0.0001), FAO (p=0.0008) and Talonavicular coverage angle (p=0.0197) compared to PCFD without STI. PCFD with TFI did not show significant difference on measurements compared to PCFD without TFI. PCFD with CFI had associated STI in 100% and TFI in 64.2% of cases. PCFD with CFI showed significant decreases of MF incongruence (p=0.0398) and significant higher FAO (p=0.0058) compared to PCFD without CFI. PCFD with both STI and CFI showed significant decreases of MF incongruence (p=0.032) and significant higher FAO (p=0.028) compared to PCFD with isolated STI. Conclusion: Our hypotheses have not been confirmed. STI was associated with both PTS and Midfoot Abduction deformities but neither TFI nor CFI were associated with PTS considering MF subluxation. Conversely, CFI was associated with a reduction of the MF incongruence angle despite being associated with a higher global deformity. STI may be associated with earlier PCFD with a concentration of the malignment forces in the subtalar joint whereas CFI may occur later and be associated with a failure of the deep layer of the deltoid ligament and a talar tilt. This could explain the relative reduction of the PTS in CFI.

Category: Ankle; Hindfoot Introduction/Purpose: Markers of diagnosis and severity are well studied in patients with Progressive Collapsing Foot Deformity (PCFD). Medial facet subluxation (MFS) in weight-bearing computerized tomography (WBCT) has been established as an indicator of peritalar subluxation and an earlier detector of the disease. When the disease affects the ankle leading to a valgus talar tilt (class E), structures distal to this topography may behavior differently, trying to compensate proximal deformity. The aim of this study is to assess predictors of deformity in PCFD patients with and without valgus of the ankle. Our hypothesis is that MFS could not be used in class E patients as an accurate value for estimation and staging of PCFD. Methods: In this IRB-approved retrospective case-control study we analyzed WBCT acquisitions of 21 consecutive patients with PCFD presenting valgus of the ankle and 64 controls (flexible PCFD with no ankle involvement). MFS (percentage of uncoverage), middle facet incongruence angle, middle cuneiform-to-floor distance, forefoot arch angle, talonavicular uncoverage angle, hindfoot moment arm (HMA), Foot and Ankle Offstet (FAO) and talar tilt angle (TTA) were obtained and compared between groups using oneway ANOVA. A multivariate regression analysis was performed to evaluate which of the measurements influenced the alignment. A partition prediction model was also constructed to find how the variables contributed to the deformity and its aspects. Statistical significancy was set in p values

Background Despite nationwide efforts to address the diabetes epidemic and reduce prevalence disparities, higher rates persist among the poor, especially those with limited literacy. Currently, individuals with abnormal glycemia who have pre-diabetes and diabetes qualify for different programs. However, evidence suggests that, for low-income Hispanic/Latinos, offering a single intervention to all those with abnormal glycemia may provide a more culturally acceptable and effective approach. Our objective was to explore the feasibility of such an intervention led by community health workers (CHWs) among low-income Hispanic/Latinos with diabetes and at risk for diabetes. Methods Using a quasi-experimental mixed method design, we assessed weight, glycosylated hemoglobin, diabetes knowledge, and behavior changes of Hispanic/Latinos participants with pre-diabetes and diabetes living in Southern California. Biometric measurements, blood tests, and surveys were collected at baseline and 3 months post-intervention. Interviews and focus group discussions provided qualitative data. Results Although the program was less costly, results exceeded those reported for low-income H/L attending the National Diabetes Prevention Program and did not differ between pre-diabetes and diabetes groups. Instead, including individuals at different stages of the dysglycemic spectrum seemed to have enhanced the intervention. Physician referral and attendance of family/friends were associated with better outcomes. Conclusion Our findings indicate that a joint prevention/self-management intervention led by CHWs for low-income Hispanic/Latinos with diabetes and with pre-diabetes is feasible and cost-effective, providing results that could help reduce the success gap. Incorporating suggestions and replicating this study on a larger scale could help determine whether or not results are reproducible.

Category: Bunion; Midfoot/Forefoot Introduction/Purpose: Rotational deformities of the first ray have been described as essential components of hallux valgus (HV) deformity, influencing its severity and progression. The exact deformity location along the medial column, as well as the typical rotational pattern of each bone, is yet to be fully understood. The objective of this study was to evaluate the rotational position of the navicular, medial cuneiform, first metatarsal and proximal phalanx using three-dimensional weightbearing CT (WBCT) images of a diversity of patients with foot pathologies. Our goal was to describe the rotational profile of medial column bones, serving as a reference for future studies. Methods: A retrospective review of patients that underwent WBCT assessment of multiple foot and ankle pathologies was conducted in a single Institution. A blinded and independent Fellowship-Trained Foot and Ankle Orthopedic Surgeon performed measurements in Multiplanar Reconstruction (MPR) WBCT images assessing the rotational profile of each bone of the medial column (navicular, medial cuneiform, first metatarsal and proximal phalanx of the great toe), as demonstrated in the attached figure. The first metatarsal, representing a long bone, was evaluated on its proximal and distal ends. A total of 110 patients were included. As standard, we considered pronation as positive values and supination as negative values. Comparisons were performed using independent t-tests or Wilcoxon tests. P-values of

Category: Ankle Arthritis Introduction/Purpose: Total ankle arthroplasty is already a reality in Brazil, although there are few publications of clinical outcomes in our country. The objective of this publication is to evaluate the results of TAA in a series of patients treated with corin system total ankle replacement Methods: 26 TAA were implanted from Jan / 13 to Aug / 16, (26 patients - 15F: 58% / 11M: 42%) (mean age: 55 years: min 37a / max 69a) using the implants Zennith from Corin (UK). Data from the clinical status (VAS, AOFAS, ADM), implant positioning and osteotomies (LTS, tibial slope, Alpha, Beta and Teta angles and distances ‘a’ and ‘b’) were evaluated in addition to the qualitative bone evolution (Peri-prosthetic cysts, sagging and wear of the components). Immediate and late information of associated surgeries, complications, and re-interventions were collected. Figure 1 present pre and post operative image Results: At 31 months of follow-up (min 4m: max 48m), there was a significant improvement in VAS (pre 8: post 2), AOFAS score (pre 37: post 77) and tibio-talar movement arch (pre 12: post 25 ) (P

Category: Hindfoot; Ankle; Other Introduction/Purpose: Adult acquired flatfoot deformity (AAFD) is a three-dimensional (3D) and complex pathology that is characterized by peritalar subluxation (PTS) of the hindfoot. Measuring the amount of subluxation of the subtalar joint at the posterior facet was described and utilized for many years as a marker of PTS. The subluxation of the middle facet was recently proposed as possibly a more accurate and reliable early marker of pronounced deformity, with almost 100% sensitivity and specificity for symptomatic AAFD. The objective of this study was to compare the amount of subluxation of both the medial and posterior facets in patients with increased hindfoot valgus and controls. Methods: In this IRB-approved retrospective comparative study, we included a total of 91 patients with AAFD (108 feet) who underwent standing weightbearing CT (WBCT) as a standard baseline assessment of their foot deformity. One blinded Fellowship- Trained Orthopedic Foot and Ankle Surgeon with more than 10 years of experience performed WBCT measurements regarding the amount of subluxation of the subtalar joint (percentage of uncoverage) at the posterior and middle facet, as previously described in the literature (Please see attached Figure). Measurements were performed at the sagittal midpoint of the articular facets using Coronal Plane WBCT images. The inter-method agreement between the posterior and middle facet subluxation was assessed using Spearman’s Correlation and Bivariate Analysis. A paired comparison of the measurements was performed using Wilcoxon. P-values of

Prostate cancer (PCa) is the most frequent tumor among Latin American (LATAM) men. The incidence of de novo metastatic PCa is higher in LATAM than other parts of the world, and demographic changes in the region have increased disease burden. However, region-specific information regarding prevalence, progression, and treatment effectiveness is not currently available for nonmetastatic, castration-resistant PCa (nmCRPC). Nonmetastatic, castration-resistant PCa is a heterogeneous disease with varying potential to develop metastasis with limited treatments available, until recently. New clinical trials with promising results have allowed second-generation antiandrogen drugs to be used as first-line treatments, rendering guidelines outdated. As a result, this panel of experts reviewed the current status and challenges and developed recommendations for nmCRPC diagnosis and management in LATAM. The Americas Health Foundation (AHF) conducted a literature review and identified LATAM scientists and clinicians who have published in the field of PCa since 2012. The AHF convened a panel of 7 chosen experts urologists and medical oncologists from the region. The AHF developed specific questions relating to nmCRPC, which were answered by the experts prior to the multiday meeting. Each narrative was discussed and edited by the panel, through numerous rounds of discussion until a consensus was reached in a final manuscript. The panel proposes specific and realistic recommendations for improving access to diagnosis and management of PCa in LATAM. No treatment has yet shown improvement in overall survival; however, when including metastasis-free survival as an end point, second-generation antiandrogen drugs have emerged as effective treatment options and are currently included as first-line treatment. Although nmCRPC is a specific disease that represents a small percentage of patients with PCa, effective diagnostic and treatment strategies can contribute toward increasing quality of life and survival rates of patients with PCa in LATAM.

Objectives: To analyze the efficacy and safety of dolutegravir/rilpivirine (DTG/RPV) in HIV-infected patients who switched from any other antiretroviral therapy (ART). Methods: Open-label, multicenter study including patients who switched to DTG/RPV between February 2015 and February 2016. Efficacy (HIV RNA

The aim of this article was to investigate the use of exergaming in promoting exercise behavior among children and to examine the impact of the intervention on participants’ exercise self-efficacy, in addition to assessing physiological changes. A sample of 55 children enrolled in the Family Fit program, where participants were categorized into 2 groups: healthy weight and overweight. Measures were taken at baseline, after the 7-week program, at the 12-week follow-up, and at the 24-month follow-up. Positive changes in exercise self-efficacy were significant for the overweight group, while the healthy weight group maintained their exercise self-efficacy. At the 24-month follow-up, 97% children reported being interested in participating in a future fitness program, and 96% children who did not play sports before the intervention started practicing sports. Exercise self-efficacy is a predictor of physical activity, and incorporating exergaming in a structured program may lead to increased self-efficacy in participants.

Aims: To study the AIDS welfare homes (AWHs) in Andalusia, assess their resources and the services provided, and describe the characteristics of their residents. Patients and Methods: Cross-sectional, observational study; an interview questionnaire technique was used with the managers and the residents of the AWHs. Results: A total of 7 AWHs and 96 residents were included; 32% of the staff were health care workers and 45.5% volunteers. The occupancy rate was 86% (2007) and 96% (2008). Residents’ characteristics: mean age 45.6 years, 73% male, 92% with at least 1 AIDS-defining disease, median Karnofsky index 60 (50-80), and median Barthel index 80 (40-100). Half the residents had physical sequelae and 31% mental sequelae. Conclusion: The AWHs perform an important role in the care of certain types of patients with HIV infection. They require human and material resources to be able to tackle the immense difficulties associated with this group of patients.