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Some researchers have questioned whether there is a causal connection between Advanced Placement (AP) STEM coursetaking and the choice of a STEM college major and a STEM occupation. Their research findings strongly suggest that if prior interest in STEM as well as other possible confounders are taken into account, the relationships of taking AP mathematics to expecting to be in a STEM major and/or a STEM occupation are small to nonexistent. Results from the current study, which uses data from a national longitudinal sample—actual measures of who majors in STEM—and prior interest in STEM along with other possible confounders, indicate that taking AP mathematics and AP science courses is significantly related to majoring in STEM and/or expecting to be in a STEM occupation at age 30—the sole exception being the taking of AP statistics.