1. Sex differences in disease profiles, management, and outcomes among people with atrial fibrillation after ischemic stroke: A meta-analysis of individual participant data.
- Author
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Anderson C., Korv J., Vibo R., Gall S., Wang X., Phan H., Reeves M., Thrift A., Cadilhac D., Sturm J., Vemmos K., Parmar P., Krishnamurthi R., Barker-Collo S., Feigin V., Cabral N., Carolei A., Sacco S., Correia M., Appelros P., Anderson C., Korv J., Vibo R., Gall S., Wang X., Phan H., Reeves M., Thrift A., Cadilhac D., Sturm J., Vemmos K., Parmar P., Krishnamurthi R., Barker-Collo S., Feigin V., Cabral N., Carolei A., Sacco S., Correia M., and Appelros P.
- Abstract
Background and Aims: We aimed to examine sex differences in disease profiles, management, and survival at 1 and 5 years after ischemic stroke (IS) among people with atrial fibrillation (AF). Method(s): Individual participant data on covariates and survival were obtained from 9 population-based stroke incidence studies conducted in Australasia, Europe, and South America (1993-2014). The presence of AF at the time of stroke onset was self-reported (2 studies) or confirmed by ECG/medical records (7 studies). The mortality rate ratio (MRR) between women and men was estimated using Poisson modelling. Study-specific unadjusted and adjusted MRRs were combined using random-effects meta-analysis. Result(s): There were 8645 participants (mean age: 72.6; 51.8% women). The pooled AF prevalence was 26.6% in women and 20.8% in men. Among the 1862 IS patients with AF, women were older than men. There were no significant sex differences in prescription of antihypertensive, antiplatelet and anticoagulation agents at admission. Crude pooled 1-year mortality was greater for women (30.4%) than men (24.5%) (1- year MRR 1.24; 95% CI, 1.01-1.51; 5-year MRR 1.28; 0.98-1.66). However, the sex difference was greatly attenuated after accounting for age, pre-stroke function and stroke severity (1-year MRR 1.09; 95% CI 0.97-1.22; 5-year MRR 0.81; 0.60-1.09). Conclusion(s): AF was more prevalent after IS among women than men. Among those with AF and IS, stroke management was similar irrespective of sex. Greater mortality in women with AF after IS was mostly attributable to pre-stroke factors. The data are very encouraging in that sex differences in management and outcomes were absent. .
- Published
- 2019