1. Fatigue in multiple sclerosis is closely related to sleep disorders: a polysomnographic cross-sectional study.
- Author
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Veauthier, C., Radbruch, H., Gaede, G., Pfueller, C. F., Dörr, J., Bellmann-Strobl, J., Wernecke, K.-D., Zipp, F., Paul, F., and Sieb, J. P.
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SLEEP disorders , *POLYSOMNOGRAPHY , *CROSS-sectional method , *INSOMNIA , *RESTLESS legs syndrome ,FATIGUE risk factors ,MULTIPLE sclerosis research - Abstract
Background: Sleep disorders can cause tiredness. The relationship between sleep disorders and fatigue in patients with multiple sclerosis (MS) has not yet been investigated systematically.Objective: To investigate the relationship between fatigue and sleep disorders in patients with MS.Methods: Some 66 MS patients 20 to 66 years old were studied by overnight polysomnography. Using a cut-off point of 45 in the Modified Fatigue Impact Scale (MFIS), the entire cohort was stratified into a fatigued MS subgroup (n = 26) and a non-fatigued MS subgroup (n = 40).Results: Of the fatigued MS patients, 96% (n = 25) were suffering from a relevant sleep disorder, along with 60% of the non-fatigued MS patients (n = 24) (p = 0.001). Sleep-related breathing disorders were more frequent in the fatigued MS patients (27%) than in the non-fatigued MS patients (2.5%). Significantly higher MFIS values were detected in all (fatigued and non-fatigued) patients with relevant sleep disorders (mean MFIS 42.8; SD 18.3) than in patients without relevant sleep disorders (mean MFIS 20.5; SD 17.0) (p < 0.001). Suffering from a sleep disorder was associated with an increased risk of fatigue in MS (odds ratio: 18.5; 95% CI 1.6–208; p = 0.018).Conclusion: Our results demonstrate a clear and significant relationship between fatigue and sleep disorders. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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