1. Dementia and Cognitive Impairment Among U.S. Veterans With a History of MDD or PTSD: A Retrospective Cohort Study Based on Sex and Race.
- Author
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Bhattarai, Jagriti "Jackie", Oehlert, Mary E., Multon, Karen D., and Sumerall, Scott W.
- Subjects
COGNITION disorder risk factors ,DEMENTIA risk factors ,DIAGNOSIS of mental depression ,DIAGNOSIS of post-traumatic stress disorder ,BLACK people ,RACE ,REGRESSION analysis ,RISK assessment ,SEX distribution ,PSYCHOLOGY of veterans ,RETROSPECTIVE studies - Abstract
Objective: The aim of this study was to examine major depressive disorder (MDD) and posttraumatic stress disorder (PTSD) diagnosed at age < 55 as predictors, and sex and race as potential moderators, of dementia and other forms of cognitive impairment. Method: Veterans (N = 4,800) aged ⩾ 56 years were grouped by psychiatric history, sex, and race. Hierarchical and stepwise regression were employed to determine significant predictors. Results: MDD and PTSD were associated with almost double the risk for developing dementia or cognitive impairment at age ⩾ 56. Sex, as a moderator, had small effects whereas race increased the risk almost twofold for Black veterans, given the presence of MDD history. Discussion: MDD and PTSD act as significant risk factors for dementia and other forms of cognitive impairment, and Black veterans, given a history of MDD, may be at an increased risk. An important endeavor for future research is to examine how this risk may vary across dementia subtypes and related conditions. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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