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Eating at night time, as is frequent in shift workers, may contribute to increased cardiovascular disease (CVD) risk through a disruption in usual lipid metabolism, resulting in repeated and sustained hyperlipidemia at night. This systematic review aimed to investigate the impact of eating a meal at night compared with the same meal eaten during the day on postprandial lipemia. Six databases were searched: CINAHL Plus, Cochrane Library, EMBASE, Ovid MEDLINE, Informit, and SCOPUS. Eligible studies were original research cross-over design with a minimum fasting period of 5 h before testing preceded by a standardized control meal; measured postprandial triacylglycerol (TAG) for 5 h or greater; had meal time between 0700 h and 1600 h for day time and between 2000 h and 0400 h for night time; and had within-study test meals (food or drink) that were identical in macronutrient composition and energy. Two authors independently completed eligibility and quality assessment using the American Dietetic Association Quality Criteria Checklist for Primary Research. After removing duplicates, 4,423 articles were screened, yielding 5 studies for qualitative synthesis. All studies identified at least one parameter of the postprandial TAG response that was different as a result of meal time (e.g., the total concentration or the time course kinetics). Two studies reported a greater total TAG concentration (area under curve) at night compared with day, and 3 studies found no difference. Four studies reported that the kinetics of the postprandial time course of TAGs was different at night compared with during the day. Inconsistent reporting in the primary studies was a limitation of the review. Night eating may negatively affect postprandial lipemia and this review shows there is a need to rigorously test this using standardized methods and analysis with larger sample sizes. This is critical for informing strategies to lower CVD risk for shift workers. [ABSTRACT FROM AUTHOR]

Objectives: Hypertension continues to cause significant morbidity and mortality worldwide, and the situation is worse in Blacks. Treatment has proved to be beneficial, but control has remained abysmal. Night-time chronotherapy is producing better control and outcome, but has only largely been tried in the West. This work attempts to see what benefits would emerge with night-time chronotherapy as compared with the current recommended morning intake of antihypertensives in an entirely African cohort.Methods: Ambulant grade 1 and 2 hypertensives attending our outpatient service were randomized after a washout period into morning or night-time ingestion groups. Drugs were tailored towards each patient’s cardiovascular disease profile and reviewed to ensure control. They were comprehensively evaluated on enrolment and 12 weeks later.Results: Both groups were similar on all scores at baseline. After 12 weeks of treatment, the mean changes in diastolic blood pressure (DBP), mean arterial pressure (MAP), left ventricular posterior diameter (LVPWD) and left ventricular mass (LVM) were greater, to a statistically significant extent in the night-time group. The difference in the systolic blood pressure (SBP) and interventricular septum diameter (IVSD) tended to be greater in the same group but did not differ between the groups to a statistically significant extent.Conclusion: Chronotherapeutic studies in the West recorded greater success with night-time ingestion which produced better control and a day-long profile. Generalization to other races was cautioned against until such observations could be replicated. We have shown that patients using their once-daily antihypertensives at night after 12 weeks recorded better reductions in SBP, DBP, MAP, LVPWD, IVSD and LVM. Since blood pressure problems run a worse course in Blacks, we recommend encouragement of night-time intake in those preferring it and suggest that in those requiring two or more drugs one should be taken at night. [ABSTRACT FROM PUBLISHER]