1. Brighter spotty lesions on spinal MRI help differentiate AQP4 antibody-positive NMOSD from MOGAD.
- Author
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Hyun, Jae-Won, Lee, Hye Lim, Park, Jaehong, Kim, Jiah, Min, Ju-Hong, Kim, Byoung Joon, Kim, Seung Woo, Shin, Ha Young, Huh, So-Young, Kim, Woojun, Seo, Ji Won, Kim, Ki Hoon, Kim, Su-Hyun, and Kim, Ho Jin
- Subjects
MYELIN oligodendrocyte glycoprotein ,MYELITIS ,MAGNETIC resonance imaging ,NEUROMYELITIS optica ,AQUAPORINS - Abstract
In a large acute myelitis cohort, we aimed to determine whether brighter spotty lesions (BSLs)—using the refined terminology—on spinal magnetic resonance imaging (MRI) help distinguish aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4-NMOSD) from myelin oligodendrocyte glycoprotein antibody disease (MOGAD). An experienced neuro-radiologist and two neurologists independently analyzed 133 spinal MRI scans (65 from MOGAD and 68 from AQP4-NMOSD) acquired within 1 month of attacks. BSLs were observed in 18 of 61 (30%) participants with AQP4-NMOSD, while none of 49 participants with MOGAD showed BSL (p < 0.001). BSL during the acute phase would be useful to differentiate AQP4-NMOSD from MOGAD. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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