1. Impact of COVID-19 on pregnancy and fetal outcomes in women with multiple sclerosis.
- Author
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Aprea, Maria Grazia, Schiavetti, Irene, Portaccio, Emilio, Ballerini, Chiara, Bonavita, Simona, Buscarinu, Maria, Calabrese, Massimiliano, Cavalla, Paola, Cellerino, Maria, Cordioli, Cinzia, Dattola, Vincenzo, De Biase, Stefano, De Meo, Ermelinda, Fantozzi, Roberta, Gallo, Antonio, Iasevoli, Luigi, Karabudak, Rana, Landi, Doriana, Lorefice, Lorena, and Moiola, Lucia
- Subjects
PREGNANCY outcomes ,COVID-19 pandemic ,PREGNANT women ,MULTIPLE sclerosis ,PREGNANCY complications - Abstract
Background: In the general population, maternal COVID-19 is associated with worse maternal and fetal outcomes. Two previous studies have assessed COVID-19 clinical outcomes in pregnant women with multiple sclerosis (MS), but there are no data about maternal and fetal outcomes. Objectives: In this multicenter study, we aimed to assess maternal and fetal outcomes in pregnant women with MS and COVID-19 infection. Methods: We recruited pregnant patients with MS who contracted COVID-19 and were followed up in Italian and Turkish Centers, during 2020–2022. A control group was extracted from a previous Italian cohort. Associations between group (COVID-19 or healthy patients) and clinical outcomes (maternal complications, fetal malformations, and spontaneous abortion) were investigated with a weighted logistic regression where propensity score–based inverse probability of treatment weighting (IPTW) approach was applied for adjusting for difference in baseline confounders. Results: In the multivariable analysis, COVID-19 during pregnancy was associated with a higher risk of maternal complications (odd ratio (OR) = 2.12; 95% confidence interval (CI) = 1.32–3.48; p = 0.002), while it was not associated with higher risk of spontaneous abortion and fetal malformations. Conclusion: Our data indicate that COVID-19 during pregnancy increases the risk of maternal complications, while it seems to have no significant impact on fetal outcomes. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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