1. Solvent-free synthesis of 3,5-di-tert-butylpyrazole and 3,5-di-substituted-butylpyrazol-1-ylethanol.
- Author
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Van Wyk, Juanita L., Omondi, Bernard, Appavoo, Divambal, Guzei, Ilia A., and Darkwa, James
- Subjects
ETHANOL ,PYRAZOLES ,AZOLES ,CRYSTAL structure ,ETHANES ,HYDROGEN bonding - Abstract
A high-yield, solvent-free approach to the synthesis of 1,3,5-trisubstituted pyrazoles is reported. Four compounds, (3,5-di-tert-butyl-1H-pyrazole, (2-(3,5-dimethyl-1H-pyrazol-1-yl)ethanol, 2-(3,5-di-tert-butyl-1H-pyrazol-1-yl)ethanol, 2-(3,5-diphenyl-1H-pyrazol-1-yl)ethanol were readily prepared by solvent-free condensation of the appropriate diketone and the respective hydrazine. The crystal structures of the three pyrazolyl-ethanols are typical of N-substituted pyrazoles. All three pyrazolyl compounds show interesting inter-molecular hydrogen bonding. For the 3,5-dimethyl compound the molecules form discrete hydrogen bonded dimers within a unit cell, while for the others the hydrogen bonding is in a head-to-tail arrangement resulting in the formation of chains. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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