1. Seroprevalence of SARS-CoV2 Infections in Health Care Personnel in a Long-Term Care Institution After the First Wave of the Pandemic: A Cross-Sectional Study.
- Author
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Bautista Balbás, Luis Alfredo, Sandino Gómez, Rosa, Gil Conesa, Mario, Velasco Guijarro, Olga, Rodríguez Caravaca, Gil, Jou Rivera, Fernando, Navasquillo Lorda, María Ángeles, and Martín Carmena, Enrique
- Subjects
RESEARCH ,SEROPREVALENCE ,COVID-19 ,IMMUNOGLOBULINS ,CONFIDENCE intervals ,CROSS-sectional method ,MULTIVARIATE analysis ,MEDICAL personnel ,INTERVIEWING ,FISHER exact test ,NURSING care facilities ,RISK assessment ,IMMUNOASSAY ,PEARSON correlation (Statistics) ,T-test (Statistics) ,PSYCHOSOCIAL factors ,QUESTIONNAIRES ,CHI-squared test ,DESCRIPTIVE statistics ,INDUSTRIAL hygiene ,SOCIODEMOGRAPHIC factors ,POLYMERASE chain reaction ,LOGISTIC regression analysis ,ODDS ratio ,DATA analysis software ,COVID-19 pandemic ,LONG-term health care - Abstract
Background: At the time of our study, occupational health evidence specific for long-term care employees was mostly lacking. The purpose of this study was to determine the proportion of positive cases in employees after the first COVID-19 wave in May 2020. We also determined the prevalence of asymptomatic cases. Method: The study population included all health care workers (HCW) employed at one mid-size long-term hospital in Spain (May 2020). A cross-sectional study design included an interviewer-administered self-reported questionnaire (including sociodemographic questions, risk factors for COVID-19 complications such as hypertension or diabetes, and previous polymerase chain reaction [PCR] results) and antibody determination (Biozek rapid test). Data were analyzed using Student's t, Fisher, and chi-square tests. Two multivariate logistic models were created to evaluate exposure factors and symptoms separately on the outcome of having had COVID-19. Findings: Of the 97% of workers who participated (580/596), 300 (51.7%) suffered symptoms of COVID-19, 161 (27.8%) of the rapid antibody tests were positive for IgM and/or IgG, 160 (27.6%) workers had at least one risk factor, and 32 (19.0%) of the 168 SARS-CoV-2-positive cases were asymptomatic. The proportion of negative or unavailable PCRs, with positive antibody, was 11.7% (56/477). Casual contact without protection (odds ratio [OR]: 1.9, 95% confidence interval [CI]: 1.1–3.4), doctor occupation (OR 3.3, 95% CI: 1.1–10.2), and nursing assistant occupation (OR 2.5, 95% CI: 1.2–5.8) were independently associated with SARS-CoV-2 infection. Conclusion: Physicians and nursing assistants in a long-term care setting were at a higher risk of SARS-COV-2 infection over other occupations in the first wave of the pandemic, especially when in contact with patients without protection. Almost one-fifth of the workers with a positive PCR test for SARS-COV-2 were asymptomatic and seroprevalence (27.8%) was well below the approximated herd immunity cutoff (60–70%). Essential workers in long-term care must be monitored frequently by Employee Health Service and should be required to wear personal protective equipment including a fit-tested N-95 while in close contact with patients and coworkers. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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