1. Clinical Outcomes after Surgery for Linitis Plastica of the Stomach: Analysis of a Population Cancer Registry.
- Author
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Chang JM, Lara KA, Gray RJ, Pockaj BA, and Wasif N
- Subjects
- Age Factors, Aged, Female, Humans, Linitis Plastica epidemiology, Linitis Plastica mortality, Linitis Plastica pathology, Male, Middle Aged, Neoplasm Staging, Retrospective Studies, SEER Program, Stomach Neoplasms epidemiology, Stomach Neoplasms mortality, Stomach Neoplasms pathology, Survival Analysis, United States epidemiology, Linitis Plastica surgery, Stomach Neoplasms surgery
- Abstract
Linitis plastica (LP), a subset of gastric adenocarcinoma (GA), has been considered as a fatal disease with few management options. Little evidence has been reported regarding the role for surgical therapy in treating LP. A retrospective review of GA patients with LP from the surveillance, epidemiology, and end results database (2004-2009) was performed. 29,440 patients with GA were identified, of whom 948 (3.2%) had LP. After matching for American Joint Commission on Cancer (AJCC) stage, LP patients had significantly worse 5-year disease specific survival (DSS) compared with GA (6 vs 34%, P < 0.001). For potentially resectable LP patients (i.e., stage I-III), 5-year DSS was 0 per cent for no treatment and for radiation therapy alone, 18 per cent for both and surgery and radiation, and 20 per cent for surgery alone(P < 0.001). LP is a marker of poor survival in patients with GA. However, surgical resection provides the best oncologic outcomes in these patients with a 20 per cent 5-year DSS in patients with loco-regional disease.
- Published
- 2017