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12. Childhood trauma in bipolar disorder

Author

Watson, Stuart, Gallagher, Peter, Dougall, Dominic, Porter, Richard, Moncrieff, Joanna, Ferrier, I Nicol, and Young, Allan H

Subjects
Male, Psychiatric Status Rating Scales, childhood trauma, Bipolar Disorder, Research, Adult Survivors of Child Abuse, Articles, Middle Aged, emotional neglect, Case-Control Studies, Surveys and Questionnaires, depression, Humans, Female
Abstract

Objective: There has been little investigation of early trauma in bipolar disorder despite evidence that stress impacts on the course of this illness. We aimed to compare the rates of childhood trauma in adults with bipolar disorder to a healthy control group, and to investigate the impact of childhood trauma on the clinical course of bipolar disorder. Methods: Retrospective assessment of childhood trauma was conducted using the Childhood Trauma Questionnaire (CTQ) in 60 outpatients with bipolar disorder being treated for a depressive episode and 55 control participants across two centres in north-east England and New Zealand. Results: Significantly higher rates of childhood trauma were observed in patients with bipolar I and bipolar II disorder compared to controls. Logistic regression, controlling for age and sex, identified emotional neglect to be the only significant CTQ subscale associated with a diagnosis of bipolar disorder. Childhood history of sexual abuse was not a significant predictor. Associations with clinical severity or course were less clear. Conclusions: Childhood emotional neglect appears to be significantly associated with bipolar disorder. Limitations include the relatively small sample size, which potentially increases the risk of type II errors. Replication of this study is required, with further investigation into the neurobiological consequences of childhood trauma, particularly emotional neglect.

Published
2014

16. Childhood trauma in bipolar disorder

Author

Watson, Stuart, primary, Gallagher, Peter, additional, Dougall, Dominic, additional, Porter, Richard, additional, Moncrieff, Joanna, additional, Ferrier, I Nicol, additional, and Young, Allan H, additional

Published
2013
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25. Breastfeeding, Antidepressants, and Depression in the Mercy Pregnancy and Emotional Well-Being Study.

Author

Galbally M, Watson SJ, Ball H, and Lewis AJ

Subjects
Antidepressive Agents therapeutic use, Cohort Studies, Depression, Postpartum drug therapy, Female, Humans, Infant, Newborn, Intention, Longitudinal Studies, Pregnancy, Pregnancy Trimesters, Prospective Studies, Psychometrics, Victoria, Breast Feeding psychology, Depression, Postpartum psychology, Postnatal Care
Abstract

Background:: Depression is consistently shown to predict lower rates of breastfeeding. In a handful of studies, breastfeeding has predicted lower depression symptoms. However, studies demonstrating the latter are limited in their measurement of both depression and breastfeeding and have not followed participants from pregnancy across the postpartum period., Research Aim:: The primary aim of this study was to describe breastfeeding intentions and behaviors for the first 12 months postpartum among nonmedicated depressed, antidepressant-exposed, and control participants. The secondary aim was to examine group differences in the association between depressive symptoms and breastfeeding duration up to 12 months postpartum., Methods:: First-trimester women ( N = 212) were recruited into a prospective longitudinal study. Depressive disorders at baseline were diagnosed using the Structured Clinical Interview for DSM-IV Axis I Disorders, and depressive symptoms were measured at the first and second trimesters and 6 and 12 months postpartum using the Edinburgh Postnatal Depression Scale. Breastfeeding duration, support from family and employers, and perceptions of participants' experience were measured., Results:: Depressed women and antidepressant-exposed women reported a trend toward lower rates of intention, initiation, and duration, but this did not reach statistical significance. There was a statistically significant difference on depressive symptoms for women taking antidepressants during pregnancy, compared with controls, when they continued to breastfeed for 12 months postpartum., Conclusions:: This study did not find a strong association between depression or antidepressant use and intention to breastfeed, partner breastfeeding support, or initiation or duration of breastfeeding. However, for women who took antidepressants, there was evidence that breastfeeding for 12 months was associated with lower depressive symptoms.

Published
2019
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26. Increased libido associated with quetiapine.

Author

Menon A, Williams RH, and Watson S

Subjects
Adult, Antipsychotic Agents therapeutic use, Dibenzothiazepines therapeutic use, Ejaculation drug effects, Humans, Male, Masturbation, Quetiapine Fumarate, Schizophrenia drug therapy, Antipsychotic Agents adverse effects, Dibenzothiazepines adverse effects, Libido drug effects, Schizophrenia complications, Schizophrenic Psychology
Abstract

We report sexual symptoms in a 44 year old man with schizophrenia who was receiving treatment with the atypical antipsychotic quetiapine. The symptoms consisted of an increased drive to masturbate and spontaneous ejaculations at night time. We discuss the potential neuro-chemical mechanisms for this and argue that quetiapine's unique pharmacological profile may have contributed to the development of his symptoms.

Published
2006
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