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Poor self-care is prevalent in patients with heart failure and adversely affects heart failure symptoms, hospitalization, and mortality. Adherence rates to different types of self-care vary in patients with heart failure. The purpose of this study was to examine factors associated with medication adherence, dietary sodium adherence, and symptom management in patients with heart failure. Data were collected using questionnaires, Medication Electronic Monitoring System, and 24-hour urine sodium output ( N  = 94). In logistic regression analysis, social support, education level, and race were associated with medication adherence ( p = .002). Gender, race, perceived control, and depressive symptoms were associated with dietary sodium adherence ( p = .030). Gender, education level, and depressive symptoms were associated with symptom management ( p = .006). Different factors were associated with each type of self-care. Thus, clinicians need to manage each type of self-care by considering factors associated with it.