1. Arming the troops: Post-translational modification of extracellular bacterial proteins
- Author
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Suzanne Forrest, Martin Welch, Welch, Martin [0000-0003-3646-1733], and Apollo - University of Cambridge Repository
- Subjects
Proteomics ,Glycosylation ,glycosylation ,Cell ,Virulence ,bacterial virulence factors ,Lipid-anchored protein ,Review ,03 medical and health sciences ,chemistry.chemical_compound ,Bacterial Proteins ,bacterial pathogens ,protein secretion ,medicine ,Extracellular ,acetylation ,030304 developmental biology ,0303 health sciences ,Multidisciplinary ,Bacteria ,biology ,030306 microbiology ,Chemistry ,biology.organism_classification ,Cell biology ,medicine.anatomical_structure ,Secretory protein ,Post-translational modification ,methylation ,lipidation ,Protein Processing, Post-Translational - Abstract
Funder: The Evelyn Trust, Funder: The Cystic Fibrosis Trust, Funder: British Lung Foundation; FundRef: https://doi.org/10.13039/501100000351, Protein secretion is almost universally employed by bacteria. Some proteins are retained on the cell surface, whereas others are released into the extracellular milieu, often playing a key role in virulence. In this review, we discuss the diverse types and potential functions of post-translational modifications (PTMs) occurring to extracellular bacterial proteins.
- Published
- 2020
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