1. The Inhibitory Effects of Representative Chalcones Contained in Angelica keiskei on Melanin Biosynthesis in B16 Melanoma Cells
- Author
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Enos Tangke Arung, Yoh Ichi Matsushita, Ryuichiro Kondo, Hiroya Ishikawa, Kuniyoshi Shimizu, Kazuhiro Sugamoto, and Shoko Furuta
- Subjects
Melanins ,Pharmacology ,Antioxidant ,Molecular Structure ,DPPH ,medicine.medical_treatment ,Tyrosinase ,Plant Science ,General Medicine ,Inhibitory postsynaptic potential ,chemistry.chemical_compound ,Chalcones ,Complementary and alternative medicine ,chemistry ,Cell Line, Tumor ,Drug Discovery ,Melanin biosynthesis ,medicine ,Animals ,Cytotoxicity ,B16 melanoma ,Angelica ,Whitening Agents - Abstract
In our effort to find new whitening agents, we evaluated the effects of representative chalcones [4-hydroxyderricin (1), xanthoangelol (2), xanthoangelol H (3), deoxyxanthoangelol H (4), and deoxydihydroxanthoangelol H (5)] contained in the stem of Angelica keiskei on tyrosinase and melanin formation in B16 melanoma cells. In addition, the antioxidant effects of these chalcones in ORAC and DPPH assays were also determined. Interestingly, all chalcones (1–5) inhibit melanin formation in B16 melanoma cells, with low cytotoxicity.
- Published
- 2012
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