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8 results on '"SCALI, E."'

5. Monilethrix Treated with Minoxidil

Author

Rossi, A., primary, Iorio, A., additional, Scali, E., additional, Fortuna, M.C., additional, Mari, E., additional, Palese, E., additional, Greco, P., additional, and Carlesimo, M., additional

Published
2011
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6. Inflammation and macrophage polarization in cutaneous melanoma: Histopathological and immunohistochemical study.

Author

Scali E, Mignogna C, Di Vito A, Presta I, Camastra C, Donato G, and Bottoni U

Subjects
Adult, Aged, Disease Progression, Female, Humans, Immunotherapy methods, Lymphocytes pathology, Macrophage Activation physiology, Male, Middle Aged, Prognosis, Skin Neoplasms, Melanoma, Cutaneous Malignant, Inflammation pathology, Macrophages pathology, Melanoma pathology
Abstract

Tumor-associated macrophages (TAMs) are considered to affect tumor growth and progression. Macrophages can be classified into two states of polarized activation, namely classically activated M1 macrophages and alternatively activated M2 macrophages. The dynamic balance between TAMs and tumor cells has an important impact on tumor homeostasis and progression. The aim of this study was to characterize the phenotype of TAMs present in different subtypes of superficial spreading cutaneous melanoma and their relationship with the lymphocytic infiltrate in order to identify new histopathological tools for melanoma prognosis and suitable targets for melanoma therapy. We selected four groups of patients with malignant melanoma in order to analyze the profile of polarized macrophage activation using immunohistochemical methods. Histopathological analysis showed that the macrophage polarization state appears to be more related to the lymphocytic infiltrate than to the thickness of the lesions. Further studies are necessary to increase understanding of the immunopathological dynamic of melanoma that may be modulated by future targeted immunotherapies., (© The Author(s) 2016.)

Published
2016
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7. Comparitive effectiveness of finasteride vs Serenoa repens in male androgenetic alopecia: a two-year study.

Author

Rossi A, Mari E, Scarno M, Garelli V, Maxia C, Scali E, Iorio A, and Carlesimo M

Subjects
Adult, Humans, Male, 5-alpha Reductase Inhibitors therapeutic use, Alopecia drug therapy, Finasteride therapeutic use, Plant Extracts therapeutic use, Serenoa
Abstract

The objective of this open label study is to determine the effectiveness of Serenoa repens in treating male androgenetic alopecia (AGA), by comparing its results with finasteride. For this purpose, we enrolled 100 male patients with clinically diagnosed mild to moderate AGA. One group received Serenoa repens 320 mg every day for 24 months, while the other received finasteride 1 mg every day for the same period. In order to assess the efficacy of the treatments, a score index based on the comparison of the global photos taken at the beginning (T0) and at the end (T24) of the treatment, was used. The results showed that only 38% of patients treated with Serenoa repens had an increase in hair growth, while 68% of those treated with finasteride noted an improvement. Moreover finasteride was more effective for more than half of the patients (33 of 50, i.e. 66%), with level II and III alopecia. We can summarize our results by observing that Serenoa repens could lead to an improvement of androgenetic alopecia, while finasteride confirmed its efficacy. We also clinically observed, that finasteride acts in both the front area and the vertex, while Serenoa repens prevalently in the vertex. Obviously other studies will be necessary to clarify the mechanisms that cause the different responses of these two treatments.

Published
2012
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8. Serum concentrations of IL-2, IL-6, IL-12 and TNF-α in patients with alopecia areata.

Author

Rossi A, Cantisani C, Carlesimo M, Scarnò M, Scali E, Mari E, Garelli V, Maxia C, and Calvieri S

Subjects
Alopecia Areata diagnosis, Alopecia Areata immunology, Biomarkers blood, Chi-Square Distribution, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Rome, Severity of Illness Index, T-Lymphocytes immunology, Alopecia Areata blood, Interleukin-12 blood, Interleukin-2 blood, Interleukin-6 blood, Tumor Necrosis Factor-alpha blood
Abstract

Alopecia areata (AA) has been represented as a restricted T cell-mediated autoimmune disease. Several studies have shown that cytokines may play an important role in its pathogenesis although many pathways exist. We investigated cytokine (IL-2, IL-6, IL-12, and TNFα) levels in peripheral blood mononuclear cell (PBMC) of 105 patients with different grade and duration of alopecia areata, to confirm that T-cell responses in AA is regulated via mechanisms of peripheral T-cell tolerance. We observed that IL-12 levels are higher for patients with bigger extensions and tend to increase according to the duration of the AA; TNFα instead, is more related to the gender of the patients and to the duration. Therefore abnormalities in cytokines production, showed by our results, may suggest that T-cell responses in AA scalp are closely regulated via mechanisms of peripheral T-cell tolerance and therefore confirm that this disease has an immuno-pathogenesis. Our aim is to shed light upon the complexity of AA underlying mechanisms and indicate pathways that may suggest future treatments.

Published
2012
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