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2. Dinimbidiol Ether, a Novel Bioactive Dimeric Diterpene from the Root Extract of Cnidoscolus souzae

Author

Karlina García-Sosa, Luis M. Peña-Rodríguez, Paulino Simá-Polanco, Reyna V. Ek Moo, and Rodolfo Aldana-Pérez

Subjects
Pharmacology, biology, 010405 organic chemistry, Stereochemistry, Cnidoscolus, Euphorbiaceae, Ether, Plant Science, General Medicine, Fractionation, 010402 general chemistry, biology.organism_classification, 01 natural sciences, 0104 chemical sciences, chemistry.chemical_compound, Complementary and alternative medicine, chemistry, Drug Discovery, Diterpene, Abietane
Abstract

The radical scavenging assay-guided fractionation of the root extract of Cnidoscolus souzae resulted in the isolation and identification of a novel bioactive dimeric diterpene with an ether linkage which has been designated as dinimbidiol ether (2). Evaluation of the antioxidant activity using the DPPH reduction assay showed that 2 is the most active metabolite in the crude extract of the plant.

Published
2017
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