1. Primary Lung Cribriform Adenocarcinoma With Squamoid Morules Harboring Somatic CTNNB1 Mutation in a Never-Smoked Healthy Adolescent
- Author
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Tracey L. Weigel, Jeremy Rosenblum, Qiqi Ye, Minghao Zhong, Hao Wu, Dana Razzano, and Oya Tugal
- Subjects
0301 basic medicine ,Pathology ,medicine.medical_specialty ,Beta-catenin ,Somatic cell ,medicine.disease_cause ,Malignancy ,Pathology and Forensic Medicine ,03 medical and health sciences ,0302 clinical medicine ,medicine ,In patient ,Mutation ,Lung ,biology ,business.industry ,General Medicine ,medicine.disease ,030104 developmental biology ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Pediatrics, Perinatology and Child Health ,Cribriform ,biology.protein ,Adenocarcinoma ,business - Abstract
Primary lung adenocarcinomas are rare in pediatric patients, and even rarer in patients without precedent malignancy or congenital malformation. Here we present the first reported case of primary lung cribriform adenocarcinoma with squamoid morules in a previously healthy adolescent female. Molecular testing identified CTNNB1 mutation in the tumor and excluded other common mutations in lung adenocarcinoma. Our case suggests molecular alterations to the same signaling pathway can lead to similar histomorphology regardless of the tissue of origin.
- Published
- 2020
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