1. Alveolar rhabdomyosarcoma of the paranasal sinuses in a 57-year-old woman with 1:16 translocation.
- Author
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Manucha V, Castellani R, and Sun CC
- Subjects
- Carcinoma, Small Cell diagnosis, Diagnosis, Differential, Esthesioneuroblastoma, Olfactory diagnosis, Female, Humans, Karyotyping, Lymphoma diagnosis, Melanoma diagnosis, Middle Aged, Myogenin analysis, Paranasal Sinus Neoplasms chemistry, Paranasal Sinus Neoplasms genetics, Rhabdomyosarcoma, Alveolar chemistry, Rhabdomyosarcoma, Alveolar genetics, Tomography, X-Ray Computed, Chromosomes, Human, Pair 1, Chromosomes, Human, Pair 16, Paranasal Sinus Neoplasms pathology, Rhabdomyosarcoma, Alveolar pathology, Translocation, Genetic
- Abstract
Alveolar rhabdomyosarcoma is an uncommon tumor. It is a rare malignancy in adults and rarely occurs in paranasal sinuses in those aged older than 50 years. This report describes a locally invasive and destructive alveolar rhabdomyosarcoma arising in the ethmoid sinus of a 57-year-old woman. The small round blue cell tumors are positive for myogenin by immunohistochemistry and have a karyotype of 45, XX, -5, -13, der(16)t(1;1) (q21;q13) by cytogenetic analysis. Fluorescence in situ hybridization demonstrated a complex translocation with break apart of the FKHR region, which supports a diagnosis of alveolar rhabdomyosarcoma. This report characterizes this tumor through microscopic and cyto-genetic analysis and emphasizes the importance of considering rhabdomyosarcoma in the differential diagnosis of small round cell tumors of the head and neck region in the middle-aged adults.
- Published
- 2006
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