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2. Sofosbuvir-based salvage therapy for HCV infection in cirrhotic patients with DAA failure and multidrug resistance.

Author

Abdurakhmanov DT, Rozina TP, Nikulkina EN, Nabatchikova EA, Chulanov VP, and Moiseev SV

Subjects
Adult, Biomarkers, Drug Therapy, Combination, Female, Hepacivirus drug effects, Hepacivirus genetics, Hepatitis C, Chronic diagnosis, Hepatitis C, Chronic virology, Humans, Liver Cirrhosis diagnosis, Male, Middle Aged, Retreatment, Salvage Therapy, Treatment Failure, Treatment Outcome, Antiviral Agents therapeutic use, Hepatitis C, Chronic complications, Hepatitis C, Chronic drug therapy, Liver Cirrhosis drug therapy, Liver Cirrhosis etiology, Sofosbuvir therapeutic use
Abstract

Despite very high efficacies of direct-acting antivirals (DAAs) reported in clinical trials, treatment failure in real-life practice can occur in 5-10% of cases and is mostly associated with emergence of resistance-associated substitutions (RASs). Little is known about the efficacy of retreatment in these patients, especially in those with decompensated cirrhosis, and only a few retreatment studies have been performed so far. Here we present case reports of successful sofosbuvir-based treatment in patients with advanced class B cirrhosis with prior pegylated interferon/ribavirin and all-oral DAA failure with multiclass drug resistance. HCV resistance testing at failure was performed to guide the choice of salvage therapy.

Published
2018
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