1. Effect of Bilateral Deep Brain Stimulation of the Subthalamic Nucleus on Freezing of Gait in Parkinson's Disease
- Author
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Xituan Ji, Jinjie Li, Gang Huang, You-Zhi Qu, Ji Ly, Dongsheng Zhao, Weiping Liu, Le Niu, and Ma Lt
- Subjects
Male ,medicine.medical_specialty ,Levodopa ,Parkinson's disease ,Deep brain stimulation ,Deep Brain Stimulation ,medicine.medical_treatment ,Neuropsychological Tests ,Biochemistry ,Parkin ,Subthalamic Nucleus ,Activities of Daily Living ,medicine ,Humans ,Prospective Studies ,Prospective cohort study ,Gait ,Aged ,medicine.diagnostic_test ,business.industry ,Biochemistry (medical) ,Parkinson Disease ,Magnetic resonance imaging ,Cell Biology ,General Medicine ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,nervous system diseases ,Surgery ,Subthalamic nucleus ,surgical procedures, operative ,nervous system ,Female ,business ,therapeutics ,medicine.drug - Abstract
OBJECTIVE: A prospective cohort study to evaluate the efficacy of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on freezing of gait (FOG) in patients with advanced Parkinson's disease. METHODS: Patients ( n = 10) with advanced Parkinson's disease were surgically implanted with microelectrodes to facilitate STN-DBS. Evaluations of FOG, motor function, activities of daily living and neuropsychological function were carried out in on-medication and off-medication states (with and without levodopa treatment), before surgery and at 6 and 12 months postoperatively. RESULTS: STN-DBS was associated with significant improvement in FOG score and neuropsychological function at both 6 and 12 months postoperatively, compared with preoperatively. Significant postoperative improvements were also observed in motor function and activities of daily living. Daily levodopa dosage was significantly lower at both 6 and 12 months postoperatively. CONCLUSIONS: STN-DBS improved FOG in patients with advanced Parkinson's disease. The significant reduction in levodopa dosage and improvement in neuropsychological function may be the reason for the therapeutic effect seen with STN-DBS.
- Published
- 2012