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33 results on '"Khoury, Jane"'

1. What is the median volume of intracerebral hemorrhage and is it changing?

Author

Robinson, David, primary, Van Sanford, Carson, additional, Kwon, Soo Young, additional, Coleman, Elisheva, additional, Sekar, Padmini, additional, Murphy, Ryan, additional, Flaherty, Matthew L, additional, Demel, Stacie L, additional, Aziz, Yasmin, additional, Moomaw, Charles J, additional, Haverbusch, Mary, additional, Khoury, Jane, additional, Adeoye, Opeolu, additional, Walsh, Kyle B, additional, Broderick, Joseph P, additional, and Woo, Daniel, additional

Published
2021
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6. Age-Dependent Patellofemoral Pain: Hip and Knee Risk Landing Profiles in Prepubescent and Postpubescent Female Athletes

Author

Galloway, Ryan T., primary, Xu, Yingying, additional, Hewett, Timothy E., additional, Barber Foss, Kim, additional, Kiefer, Adam W., additional, DiCesare, Christopher A., additional, Magnussen, Robert A., additional, Khoury, Jane, additional, Ford, Kevin R., additional, Diekfuss, Jed A., additional, Grooms, Dustin, additional, Myer, Gregory D., additional, and Montalvo, Alicia M., additional

Published
2018
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7. Pediatric Stroke Rates Over 17 Years: Report From a Population-Based Study

Author

Lehman, Laura L., primary, Khoury, Jane C., additional, Taylor, J. Michael, additional, Yeramaneni, Samrat, additional, Sucharew, Heidi, additional, Alwell, Kathleen, additional, Moomaw, Charles J., additional, Peariso, Katrina, additional, Flaherty, Matthew, additional, Khatri, Pooja, additional, Broderick, Joseph P., additional, Kissela, Brett M., additional, and Kleindorfer, Dawn O., additional

Published
2018
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9. Hyperlipidemia is associated with lower risk of poststroke mortality independent of statin use: A population-based study

Author

Yeramaneni, Samrat, primary, Kleindorfer, Dawn O, additional, Sucharew, Heidi, additional, Alwell, Kathleen, additional, Moomaw, Charles J, additional, Flaherty, Matthew L, additional, Woo, Daniel, additional, Adeoye, Opeolu, additional, Ferioli, Simona, additional, de los Rios La Rosa, Felipe, additional, Martini, Sharyl, additional, Mackey, Jason, additional, Khatri, Pooja, additional, Kissela, Brett M, additional, and Khoury, Jane C, additional

Published
2016
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13. Effects of Gender on Gene Expression in the Blood of Ischemic Stroke Patients

Author

Tian, Yingfang, primary, Stamova, Boryana, additional, Jickling, Glen C, additional, Liu, Dazhi, additional, Ander, Bradley P, additional, Bushnell, Cheryl, additional, Zhan, Xinhua, additional, Davis, Ryan R, additional, Verro, Piero, additional, Pevec, William C, additional, Hedayati, Nasim, additional, Dawson, David L, additional, Khoury, Jane, additional, Jauch, Edward C, additional, Pancioli, Arthur, additional, Broderick, Joseph P, additional, and Sharp, Frank R, additional

Published
2011
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20. Gene Expression in Peripheral Blood Differs after Cardioembolic Compared with Large-Vessel Atherosclerotic Stroke: Biomarkers for the Etiology of Ischemic Stroke

Author

Xu, Huichun, primary, Tang, Yang, additional, Liu, Da-Zhi, additional, Ran, Ruiqiong, additional, Ander, Bradley P, additional, Apperson, Michelle, additional, Liu, Xin She, additional, Khoury, Jane C, additional, Gregg, Jeffrey P, additional, Pancioli, Arthur, additional, Jauch, Edward C, additional, Wagner, Kenneth R, additional, Verro, Piero, additional, Broderick, Joseph P, additional, and Sharp, Frank R, additional

Published
2008
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22. Letters to the Editor

Author

Lederman, Sally Ann, primary, Hopkinson, Judy, additional, Geraghty, Sheela R., additional, Khoury, Jane C., additional, Kalkwarf, Heidi J., additional, Walshaw, C A, additional, (Ramsay), Donna Geddes, additional, Wilson-Clay, Barbara, additional, Hoover, Kay, additional, and Erickson, Tracy, additional

Published
2006
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25. Gene Expression in Blood Changes Rapidly in Neutrophils and Monocytes after Ischemic Stroke in Humans: A Microarray Study

Author

Tang, Yang, primary, Xu, Huichun, additional, Du, Xin Li, additional, Lit, Lisa, additional, Walker, Wynn, additional, Lu, Aigang, additional, Ran, Ruiqiong, additional, Gregg, Jeffrey P, additional, Reilly, Melinda, additional, Pancioli, Art, additional, Khoury, Jane C, additional, Sauerbeck, Laura R, additional, Carrozzella, Janice A, additional, Spilker, Judith, additional, Clark, Joseph, additional, Wagner, Kenneth R, additional, Jauch, Edward C, additional, Chang, Dongwoo J, additional, Verro, Piero, additional, Broderick, Joseph P, additional, and Sharp, Frank R, additional

Published
2006
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28. What is the median volume of intracerebral hemorrhage and is it changing?

Author

Robinson D, Van Sanford C, Kwon SY, Coleman E, Sekar P, Murphy R, Flaherty ML, Demel SL, Aziz Y, Moomaw CJ, Haverbusch M, Khoury J, Adeoye O, Walsh KB, Broderick JP, and Woo D

Subjects
Cerebral Hemorrhage diagnostic imaging, Cerebral Hemorrhage epidemiology, Cerebral Hemorrhage etiology, Cross-Sectional Studies, Humans, Risk Factors, Tomography, X-Ray Computed, Stroke complications
Abstract

Objectives: Population-level estimates of the median intracerebral hemorrhage (ICH) volume would allow for the evaluation of clinical trial external validity and determination of temporal trends. We previously reported the median ICH volume in 1988. However, differences in risk factor management, neuroimaging, and demographics may have affected ICH volumes. The goal of this study is to determine the median volume of ICH within a population-based cross-sectional study, including whether it has changed over time., Methods: The Genetic and Environmental Risk Factors for Hemorrhagic Stroke study was a population-based study of ICH among residents of the Greater Cincinnati/Northern Kentucky region from 2008 through 2012. This study utilizes those data and compares with ICH cases from the same region in 1988. Initial computed tomography images of the head were reviewed, and ICH volumes were calculated using consistent methodology., Results: From 2008 through 2012, we identified 1117 cases of ICH. The median volume of ICH was 14.0 mL and was lower in black (11.6) than in white (15.5) patients. Median volumes of lobar and deep ICH were 28.8 mL and 9.8 mL, respectively. Median ICH volume changed significantly from 1988 to 2008-2012, with age-and-race-adjusted volume decreasing from 18.3 mL to 13.76 mL (p = 0.025)., Conclusions: Median volume of ICH was 13.76 mL, and this should be considered in clinical trial design. Median ICH volume has apparently decreased from 1988 to 2008-2012.

Published
2022
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29. Early Infant Attention as a Predictor of Social and Communicative Behavior in Childhood.

Author

Bowers K, Khoury J, Sucharew H, Xu Y, Chen A, Lanphear B, and Yolton K

Abstract

Background: The objective was to determine whether infant neurobehavior measured at five post-gestational weeks could predict social and communicative behavior (SCB) through five and eight years., Methods: Infant neurobehavior was assessed using the Neonatal Intensive Care Unit Network Neurobehavioral Scale, and SCB was measured using the Social Responsiveness Scale (SRS). Adjusted linear regression with generalized estimating equations were employed to estimate the association between infant neurobehavior and SCB. Interaction terms and stratification were used to identify potential effect modification by autism spectrum disorder risk factors., Results: The analyses include n = 214 and n = 227 participants who were examined at 5 weeks and followed to 4/5 and 8 years, respectively. Adjusting for maternal age, race, parity, and education as well as gestational age, only the Neonatal Intensive Care Unit Network Neurobehavioral Scale summary score of "attention" (measured at mean 43.9 gestational weeks) was inversely associated with total SRS T-score through 5 years. However, in analyses stratified by maternal age, the inverse association between "attention" and SCB was significant, but only among offspring of women of advanced maternal age (≥35 y); in addition, higher scores of "excitability," "lethargy," and "arousal" were associated with increased total SRS T scores among women of advanced maternal age. The associations were no longer statistically significant at 8 years., Conclusions: Newborns with lower scores on the attention subscale (determined by an ability to localize and track animate and inanimate objects) were more likely to demonstrate deficits in SCB. In addition, infants with increased excitability, lethargy, or increased arousal were more likely to have impaired SCB that persisted through 5 years, but not at 8 years of age. Further work is necessary to identify specific aspects of infant neurobehavior that may affect childhood SCBs.

Published
2019
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30. Hyperlipidemia is associated with lower risk of poststroke mortality independent of statin use: A population-based study.

Author

Yeramaneni S, Kleindorfer DO, Sucharew H, Alwell K, Moomaw CJ, Flaherty ML, Woo D, Adeoye O, Ferioli S, de Los Rios La Rosa F, Martini S, Mackey J, Khatri P, Kissela BM, and Khoury JC

Subjects
Aged, Aged, 80 and over, Brain Ischemia complications, Brain Ischemia drug therapy, Female, Humans, Hyperlipidemias drug therapy, Hyperlipidemias metabolism, Hyperlipidemias mortality, Male, Middle Aged, Multivariate Analysis, Proportional Hazards Models, Retrospective Studies, Stroke complications, Stroke drug therapy, Survival Analysis, Time Factors, Treatment Outcome, Brain Ischemia metabolism, Brain Ischemia mortality, Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use, Hyperlipidemias complications, Stroke metabolism, Stroke mortality
Abstract

Background Although statin therapy is associated with reduced stroke and mortality risk, some studies report that higher lipid levels are associated with improved outcomes following ischemic stroke. Aims We examined the association of hyperlipidemia (HLD) combined with statin therapy on all-cause mortality in stroke patients. Methods All stroke patients in the Greater Cincinnati Northern Kentucky region of ∼1.3 million were identified using ICD-9 discharge codes in 2005 and 2010. Stroke patients with and without HLD were categorized based on their reported statin use at baseline or discharge into three groups: no-HLD/no-statins, HLD/no-statins, and HLD/on-statins. Cox proportional hazards model was used to estimate the risk of mortality at 30 days, 1 year, and 3 years poststroke. Results Overall, 77% (2953) of the 3813 ischemic stroke patients were diagnosed with HLD and 72% ( n = 2123) of those patients were on statin medications. The mean age was 70.0 ± 14.6 years, 56% were women, and 21% were black. In adjusted analyses, the HLD/no-statins group showed 35% (adjusted hazard ratio (aHR) = 0.65, 95% CI: 0.46-0.92), 27% (aHR = 0.73, 95% CI: 0.59-0.90), and 17% (aHR = 0.83, 95% CI: 0.70-0.97) reduced risk of mortality at 30 days, 1 year, and 3 years, respectively, poststroke, compared with no-HLD/no-statins group. The HLD/on-statins group showed an additional 17% significant survival benefit at 3 years poststroke compared with HLD/no-statins group. Conclusions A diagnosis of HLD in ischemic stroke patients is associated with reduced short- and long-term mortality, irrespective of statin use. Statin therapy is associated with significant, additional long-term survival benefit.

Published
2017
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32. Effects of gender on gene expression in the blood of ischemic stroke patients.

Author

Tian Y, Stamova B, Jickling GC, Liu D, Ander BP, Bushnell C, Zhan X, Davis RR, Verro P, Pevec WC, Hedayati N, Dawson DL, Khoury J, Jauch EC, Pancioli A, Broderick JP, and Sharp FR

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Brain Ischemia genetics, Brain Ischemia immunology, Female, Gene Expression Profiling, Humans, Male, Middle Aged, Oligonucleotide Array Sequence Analysis, Stroke genetics, Stroke immunology, Brain Ischemia blood, Gene Expression Regulation, Sex Characteristics, Stroke blood
Abstract

This study examined the effects of gender on RNA expression after ischemic stroke (IS). RNA obtained from blood of IS patients (n=51; 153 samples at < or =3, 5, and 24 hours) and from matched controls (n=52) were processed on Affymetrix microarrays. Analyses of covariance for stroke versus control samples were performed separately for both genders and the regulated genes for females compared with males. In all, 242, 227, and 338 male-specific genes were regulated at < or =3, 5, and 24 hours after IS, respectively, of which 59 were regulated at all time points. Overall, 774, 3,437, and 571 female-specific stroke genes were regulated at < or =3, 5, and 24 hours, respectively, of which 152 were regulated at all time points. Male-specific stroke genes were associated with integrin, integrin-liked kinase, actin, tight junction, Wnt/β-catenin, RhoA, fibroblast growth factors (FGF), granzyme, and tumor necrosis factor receptor (TNFR)2 signaling. Female-specific stroke genes were associated with p53, high-mobility group box-1, hypoxia inducible factor (HIF)1α, interleukin (IL)1, IL6, IL12, IL18, acute-phase response, T-helper, macrophage, and estrogen signaling. Cell death signaling was overrepresented in both genders, although the molecules and pathways differed. Gender affects gene expression in the blood of IS patients, which likely implies gender differences in immune, inflammatory, and cell death responses to stroke.

Published
2012
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