1. Metabolism of Acetoacetate-3-C14 by Mammalian Heart Muscle
- Author
-
Ted M. Bow and Joe Meyer
- Subjects
Mammals ,medicine.medical_specialty ,Glycogen ,Myocardium ,Endogeny ,Lipid metabolism ,Metabolism ,Biology ,Lipid Metabolism ,General Biochemistry, Genetics and Molecular Biology ,Mammalian heart ,Acetoacetates ,Citric acid cycle ,chemistry.chemical_compound ,Endocrinology ,chemistry ,Biochemistry ,Internal medicine ,Ketone bodies ,medicine ,Animals ,Dog heart - Abstract
SummaryThe metabolic path of aceto-acetate-3-C14 in the isolated dog heart has been determined using the isotopic distribution in the endogenous malate and succinate as an internal metabolic indicator. Isotopic carbon was found exclusively in the carboxyl groups of malate and succinate as would be expected if acetoacetate was being utilized only by the established path (acetoacetate - → 2 “acetate” → 4 C02 via the tricarboxylic acid cycle). This is taken as corroborative evidence for our previous conclusion that ketone bodies per se are not responsible for the net increase in cardiac glycogen noted in ketonemia.
- Published
- 1956