1. Association Between Olfactory and Gustatory Dysfunction and Cognition in Older Adults
- Author
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Cyrelle R. Fermin, Spencer C. Payne, Jamiluddin Qazi, Jose L. Mattos, James H Wilson, and Ian Churnin
- Subjects
Taste ,National Health and Nutrition Examination Survey ,Neuropsychological Tests ,Olfaction Disorders ,Taste Disorders ,03 medical and health sciences ,0302 clinical medicine ,Odds Ratio ,Prevalence ,Humans ,Immunology and Allergy ,Medicine ,Dementia ,Cognitive Dysfunction ,Cognitive decline ,Association (psychology) ,Cognitive impairment ,Aged ,030304 developmental biology ,Aged, 80 and over ,0303 health sciences ,business.industry ,Cognition ,General Medicine ,Middle Aged ,medicine.disease ,Health Surveys ,United States ,Smell ,Otorhinolaryngology ,business ,030217 neurology & neurosurgery ,Clinical psychology - Abstract
Background The association between olfactory dysfunction (OD) and cognitive decline is becoming apparent in the emerging literature. However, the literature demonstrating a similar effect between gustatory dysfunction (GD) and cognition is not well established. Objective To determine whether OD and GD are independently associated with cognitive impairment. Methods The 2013–2014 National Health and Nutrition Examination Survey was queried for 1376 older adults, corresponding to a weighted population sample of 50 816 529, to assess olfactory and gustatory status and cognition using univariate and multivariate regression analyses. OD and GD were determined using objective measurements with validated protocols. Participants were stratified as normal or abnormal cognition status using accepted cutoff values as indicated for the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) neuropsychological test, Animal Fluency Test (AFT), and Digit Symbol Substitution Test (DSST). Results OD was associated with both mild cognitive impairment (odds ratio [OR] 1.809, P = .004) and dementia (OR 3.173, P Conclusions OD and severe GD represent independent predictors of cognitive impairment in a nationally representative sample of older adults.
- Published
- 2019