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Start Over Author "Hu, Yuewen" Publisher sage publications
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2. Association between MTHFR C677T polymorphism and venous thromboembolism risk in the Chinese population: a meta-analysis of 24 case-controlled studies.

Author

Zhang P, Gao X, Zhang Y, Hu Y, Ma H, Wang W, Wang H, Zhang J, Xu H, and Lu Z

Subjects
Case-Control Studies, Chi-Square Distribution, China epidemiology, Genetic Predisposition to Disease, Humans, Odds Ratio, Phenotype, Risk Factors, Venous Thromboembolism enzymology, Venous Thromboembolism ethnology, Asian People genetics, Methylenetetrahydrofolate Reductase (NADPH2) genetics, Polymorphism, Genetic, Venous Thromboembolism genetics
Abstract

The association between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and venous thromboembolism (VTE) risk in the Chinese population has been widely reported, but results were inconsistent and underpowered. To elucidate the variable results, a meta-analysis and systematic review were performed from all case-controlled studies relating MTHFR C677T polymorphism by pooling data on them. We estimated the pooled odds ratio with its 95% confidence intervals to assess this possible association. Finally, a total of 24 studies with 2339 cases and 4048 controls were included in the current meta-analysis. Significant association was found with VTE risk for all genetic models. Subgroup analyses by type of VTE further identified the above-mentioned association in deep vein thrombosis/pulmonary embolism and splanchnic vein thrombosis. The findings from our meta-analysis support the associations of MTHFR C677T polymorphism with VTE risk in the Chinese population., (© The Author(s) 2014.)

Published
2015
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