1. Trajectories of the Psychological Status of Mothers of Infants With Nonsyndromic Orofacial Clefts: A Prospective Cohort Study From the Japan Environment and Children’s Study
- Author
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Toshinobu Miyamoto, Yusuke Tanahashi, Yasuaki Saijo, Reiko Kishi, Hiroshi Azuma, Chihiro Miyashita, Machiko Minatoya, Yu Ait Bamai, Keiko Yamazaki, Sumitaka Kobayashi, Yukihiro Sato, Atsuko Araki, Kazuo Sengoku, Sachiko Ito, Yoshiya Ito, and Eiji Yoshioka
- Subjects
Pediatrics ,medicine.medical_specialty ,business.industry ,Cleft Lip ,Infant ,Mothers ,030206 dentistry ,Cleft Palate ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Otorhinolaryngology ,Psychological status ,Pregnancy ,Case-Control Studies ,Humans ,Medicine ,Female ,Psychological testing ,Prospective Studies ,030212 general & internal medicine ,Oral Surgery ,Child ,Prospective cohort study ,business - Abstract
Objective: This study examined psychological status trajectories of mothers of infants with nonsyndromic orofacial clefts in Japan. Design: Prospective cohort study. Setting: Data from the Japan Environment and Children’s Study. Participants: Infants with a nonsyndromic cleft (N = 148) including cleft lip and palate (CLP; n = 72), cleft lip (CL; n = 46), and cleft palate (CP; n = 30). The control group included unaffected infants (N = 84 454). Main Outcome Measures: At 15 weeks and 27 weeks of pregnancy and 12 months after birth, the Kessler Psychological Distress Scale (clinical cutoff ≥5) was used. At 1 month and 6 months after birth, the Edinburgh Postnatal Depression Scale (clinical cutoff ≥9) was used. Results: Prenatal diagnosis rates were unavailable. Mothers of infants with CLP had higher psychological distress than controls at 27 weeks of pregnancy (prevalence ratio [PR] = 1.36, 95% CI: 1.06-1.74) and postnatal depression at 1 month after birth (PR = 2.21, 95% CI: 1.53-3.19). Mothers of infants with CP showed heightened psychological distress at 27 weeks of pregnancy (PR = 1.62, 95% CI: 1.21-2.17) and postnatal depression 6 months after birth (PR = 1.86, 95% CI: 1.01-3.43). There was no significant association between CL and maternal psychological status. At 12 months after birth, no differences in distress were found between mothers of infants with a cleft and controls. Conclusions: Mothers of infants with orofacial clefts may need psychosocial support, particularly during pregnancy and the first year after birth.
- Published
- 2020