1. Development of a Radioimmunoassay for Pregnancy-Associated Plasma Protein A and Establishment of Normal Levels in the First Trimester of Pregnancy
- Author
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G. M. Masson, Peter J. Wood, and Frederick W. Anthony
- Subjects
Male ,030213 general clinical medicine ,medicine.medical_specialty ,Pregnancy-associated plasma protein A ,Placenta ,Clinical Biochemistry ,Radioimmunoassay ,030209 endocrinology & metabolism ,Pregnancy Proteins ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,Reference Values ,Internal medicine ,medicine ,Humans ,Pregnancy-Associated Plasma Protein-A ,chemistry.chemical_classification ,business.industry ,General Medicine ,medicine.disease ,Blood proteins ,Pregnancy Trimester, First ,First trimester ,Endocrinology ,chemistry ,Double antibody ,Gestation ,Female ,Glycoprotein ,business - Abstract
An accelerated double antibody method has been developed for the radioimmunoassay of pregnancy-associated plasma protein A (PAPP-A) in serum. The workable range for the assay was 0·04–1·8 mg/l of serum. PAPP-A levels were determined in single serum samples from 110 women with prospective normal pregnancies of between 7 and 14 weeks' gestation. The level of pregnancy specific β1 glycoprotein (SP1) was also measured in these samples and normal ranges for PAPP-A and SP1 were constructed from the results obtained.
- Published
- 1983
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