PART ONE INTRODUCTION: Life events and measurement, George W. Brown. PART TWO LIFE EVENTS AND PSYCHIATRIC ILLNESS: Depression, George W. Brown and Tirril O. Harris Anxiety, Robert Finlay-Jones Schizophrenia, Richard Day Endocrine changes and clinical profiles in depression, Paul Calloway and Raymond Dolan Diseases Adversity and psychiatric disorder - a decay model, Paul G. Surtees. PART THREE LIFE EVENTS AND PHYSICAL ILLNESS: Physical illness - an introduction, Tirril O. Harris Appendectomy, Francis Creed Abdominal pain, Tom K.J. Craig Disorders of menstruation, Tirril O. Harris Multiple sclerosis, Igor Grant et al Myocardial infarction, Eileen Neilson Outset, George W. Brown and Michael Marmot Functional dysphonia, Harry Andrews Interlude - the origins of life events and difficulties, George W. Brown and Tirril O. Harris. PART FOUR EPILOGUE: The LEDS findings in the context of other research - an overview, Tirril O. Harris and George W. Brown Summary and conclusions, George W. Brown and Tirril O. Harris.