1. Treatment of Advanced Gastric Cancer with Cetuximab plus Chemotherapy followed by Surgery. Report of a Case
- Author
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Carmine Pinto, Riccardo Casadei, Gianluca Sciannamea, Daniela Rega, Francesco Monari, Claudio Ricci, Francesco Minni, R. Casadei, D. Rega, C. Pinto, F. Monari, C. Ricci, G. Sciannamea, and F. Minni.
- Subjects
Adult ,Cancer Research ,medicine.medical_specialty ,NEOPLASM ,SURGERY ,medicine.medical_treatment ,Docetaxel ,Antibodies, Monoclonal, Humanized ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Gastrectomy ,Stomach Neoplasms ,STOMACH ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Humans ,neoplasms ,Neoadjuvant therapy ,Neoplasm Staging ,Cisplatin ,Chemotherapy ,Cetuximab ,business.industry ,Antibodies, Monoclonal ,Cancer ,General Medicine ,CHEMOTHERAPY ,Advanced gastric cancer ,medicine.disease ,digestive system diseases ,CETUXIMAB ,Surgery ,Treatment Outcome ,Oncology ,030220 oncology & carcinogenesis ,Female ,Taxoids ,business ,medicine.drug - Abstract
The prognosis of patients affected by advanced gastric cancer who did not undergo non-curative resection is extremely poor. We report a case of a 26-year-old woman affected by gastric cancer with peritoneal carcinosis in whom surgical treatment was not considered. The patient was enrolled in the Italian phase II trial of cetuximab (Erbitux, Merck KGaA, Darmstadt, Germany), a monoclonal antibody, in combination with docetaxel and cisplatin chemotherapy. Restaging of the tumor showed progressive regression, so the patient underwent a total gastrectomy. The patient is alive, well and disease-free ten months after surgery. The good result achieved in this patient provides interesting prospects for chemotherapy combined with cetuximab, followed by surgery.
- Published
- 2009
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