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Objective: To investigate the entire spinal cord (SC) of multiple sclerosis (MS) patients with biplanar MRI and to relate these MRI findings to clinical functional scores., Methods: Two hundred and two patients (140 women, 62 men 24-74 years, Expanded Disability Status Scale (EDSS) scores 0-7.5) were investigated clinically and with biplanar MRI. Sagittal and axial proton density weighted (PDw) and T2 weighted (T2w) images of the whole SC were obtained employing parallel imaging. Data were analyzed by consensus reading using a standardized reporting scheme. Different combinations of findings were compared to EDSS scores with Spearman's rank correlation coefficient (ρ)., Results: The combined analysis of sagittal and axial planes demonstrated slightly differing results in 97/202 (48%) patients. There were 9% additional lesions identified, leading to a higher lesion count in 28% of these patients, but also rejection of equivocal abnormality leading to a lower lesion count in 11% of patients. Considering both sagittal and axial images, SC abnormalities were found in 167/202 (83%) patients. When compared with EDSS scores, the combination of focal lesions, signs of atrophy and diffuse abnormalities showed a moderate correlation (ρ=0.52), that precludes its use for individual patient assessment., Conclusion: Biplanar MRI facilitates a comprehensive identification, localization, and grading of pathological SC findings in MS patients. This improves the confidence and utility of SC imaging.

Background: For the reconstruction of acromioclavicular (AC) joint separation, several operative procedures have been described; however, the anatomic reconstruction of both coracoclavicular ligaments has rarely been reported., Purpose: The aim of this biomechanical study is to describe a new procedure for anatomic reconstruction of the AC joint., Study Design: Controlled laboratory study., Materials and Methods: Forty fresh-frozen cadaveric shoulders were tested. Cyclic loading and a load-to-failure protocol was performed in vertical (native, n = 10; reconstructed, n = 10) and anterior directions (native, n = 10; reconstructed, n = 10) on 20 AC joints and repeated after anatomic reconstruction. Reconstruction of conoid and trapezoid ligaments was achieved by 2 TightRope devices (Arthrex, Naples, Florida). Dynamic, cyclic, and static loading until failure in vertical (n = 5) and horizontal (n = 5) directions were tested in native as well as reconstructed joints in a standardized setting., Results: The native coracoclavicular ligaments in static load for vertical force measured 598 N (range, 409-687), elongation 10 mm (range, 6-14), and stiffness 99 N/mm (range, 67-130); static load for anterior force was 338 N (range, 186-561), elongation 4 mm (range, 3-7), and stiffness 140 N/mm (range, 70-210). The mean maximum static load until failure in reconstruction for vertical force was 982 N (range, 584-1330) (P =.001), elongation 4 mm (range, 3-6) (P < .001), and stiffness 80 N/mm (range, 66.6-105) (P = .091); and for anterior static force 627 N (range, 364-973) (P < .001), elongation 6.5 mm (range, 4-10) (P = .023), and stiffness 78 N/mm (range, 46-120) (P = .009). During dynamic testing of the native coracoclavicular ligaments, the mean amount of repetitions (100 repetitions per stage, stage 0-100 N, 100-200 N, 200-300 N, etc, and a frequency of 1.5 Hz) in native vertical direction was 593 repetitions (range, 426-683) and an average of 552 N (range, 452-683) load until failure. In vertical reconstructed testing, there were 742 repetitions (range, 488-893) (P = .222) with a load until failure of 768 N (range, 486-900) (P = .095). In the anterior direction load, the native ligament failed after an average of 365 repetitions (range, 330-475) and an average load of 360 N (range, 307-411), while reconstructed joints ended in 549 repetitions (range, 498-566) (P = .008) with a load until failure of 547 N (range, 490-585) (P = .008). In all testing procedures, a preload of 5 N was performed., Conclusion: The anatomic reconstruction of the AC joint using TightRope is a stable and functional anatomic reconstruction procedure. The reconstruction technique led to favorable in vitro results with equal or even higher forces than native ligaments., Clinical Relevance: Through anatomic repair, stable function of the AC joint can be achieved in an anatomic manner.